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1,5-Disubstituted Acylated 2-Amino-4,5-dihydroimidazoles as a New Class of Retinoic Acid Receptor-Related Orphan Receptor (ROR) Inhibitors

International journal of molecular sciences, 2022-04, Vol.23 (8), p.4433

2022

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Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase

Bioorganic & medicinal chemistry letters, 2020-05, Vol.30 (9), p.127108-127108, Article 127108

2020

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Synthesis and pharmacological evaluations of novel 2H-benzo[b][1,4] oxazin-3(4H)-one derivatives as a new class of anti-cancer agents

European journal of medicinal chemistry, 2011-10, Vol.46 (10), p.4887-4896

2011

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Necrotic Concentrations of Cisplatin Activate the Apoptotic Machinery but Inhibit Effector Caspases and Interfere with the Execution of Apoptosis

Toxicological sciences, 2011-07, Vol.122 (1), p.73-85

2011

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An Alu Element in the Myeloperoxidase Promoter Contains a Composite SP1-Thyroid Hormone-Retinoic Acid Response Element

The Journal of biological chemistry, 1996-06, Vol.271 (24), p.14412-14420

1996

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Leveraging Atropisomerism to Obtain a Selective Inhibitor of RET Kinase with Secondary Activities toward EGFR Mutants

ACS chemical biology, 2019-09, Vol.14 (9), p.1930-1939

2019

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Controlling Ibrutinib’s Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity

ACS medicinal chemistry letters, 2023-03, Vol.14 (3), p.305-311

2023

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Diversity oriented synthesis and IKK inhibition of aminobenzimidazole tethered quinazoline-2,4-diones, thioxoquinazolin-4-ones, benzodiazepine-2,3,5-triones, isoxazoles and isoxazolines

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (3), p.685-689

2015

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Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm

Bioorganic & medicinal chemistry letters, 2017-09, Vol.27 (18), p.4462-4466

2017

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Synthesis of dihydroimidazole tethered imidazolinethiones and their activity as novel antagonists of the nuclear retinoic acid receptor-related orphan receptors (RORs)

Bioorganic & medicinal chemistry letters, 2017-04, Vol.27 (7), p.1608-1610

2017

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Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation

Molecular and Cellular Biology, 1997-11, Vol.17 (11), p.6348-6358

1997

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Peroxisome Proliferator-activated Receptor γ Ligands Regulate Myeloperoxidase Expression in Macrophages by an Estrogen-dependent Mechanism Involving the -463GA Promoter Polymorphism

The Journal of biological chemistry, 2004-02, Vol.279 (9), p.8300-8315

2004

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Common Mode Noise Propagation and Effects in a Four-Wheel Drive Electric Vehicle

IEEE transactions on electromagnetic compatibility, 2018-02, Vol.60 (1), p.132-139

2018

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In silico identification of novel EGFR inhibitors with antiproliferative activity against cancer cells

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1969-1974

2006

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Inhibition of IκB Kinase by a New Class of Retinoid-Related Anticancer Agents That Induce Apoptosis

Molecular and Cellular Biology, 2003-02, Vol.23 (3), p.1061-1074

2003

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Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids

Bioorganic & medicinal chemistry, 2014-02, Vol.22 (4), p.1285-1302

2014

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Adamantyl Arotinoids That Inhibit IκB Kinase α and IκB Kinase β

ChemMedChem, 2013-07, Vol.8 (7), p.1184-1198

2013

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Highly twisted adamantyl arotinoids: Synthesis, antiproliferative effects and RXR transactivation profiles

European journal of medicinal chemistry, 2009-06, Vol.44 (6), p.2434-2446

2009

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Z-FA-fmk inhibits effector caspases but not initiator caspases 8 and 10, and demonstrates that novel anticancer retinoid-related molecules induce apoptosis via the intrinsic pathway

Molecular cancer therapeutics, 2003-03, Vol.2 (3), p.255-263

2003

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The extrinsic and intrinsic apoptotic pathways are differentially affected by temperature upstream of mitochondrial damage

Apoptosis (London), 2006-08, Vol.11 (8), p.1339-1347

2006

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Retinoids in combination therapies for the treatment of cancer: mechanisms and perspectives

Drug resistance updates, 2002-07, Vol.5 (3), p.162-175

2002

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The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands

Biochemical and biophysical research communications, 2006-10, Vol.349 (2), p.846-854

2006

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The retinoid antagonist MX781 induces clusterin expression in prostate cancer cells via heat shock factor-1 and activator protein-1 transcription factors

Cancer research (Chicago, Ill.), 2004-08, Vol.64 (16), p.5905-5912

2004

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Leveraging atropisomerism to obtain a selective inhibitor of RET kinase with secondary activities towards EGFR mutants

ACS chemical biology, 2019-08, Vol.14 (9), p.1930-1939

2019

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1,5-Disubstituted Acylated 2-Amino-4,5-dihydroimidazoles as a New Class of Retinoic Acid Receptor-Related Orphan Receptor (ROR) Inhibitors

Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase

Synthesis and pharmacological evaluations of novel 2H-benzo[b][1,4] oxazin-3(4H)-one derivatives as a new class of anti-cancer agents

Necrotic Concentrations of Cisplatin Activate the Apoptotic Machinery but Inhibit Effector Caspases and Interfere with the Execution of Apoptosis

An Alu Element in the Myeloperoxidase Promoter Contains a Composite SP1-Thyroid Hormone-Retinoic Acid Response Element

Leveraging Atropisomerism to Obtain a Selective Inhibitor of RET Kinase with Secondary Activities toward EGFR Mutants

Controlling Ibrutinib’s Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity

Diversity oriented synthesis and IKK inhibition of aminobenzimidazole tethered quinazoline-2,4-diones, thioxoquinazolin-4-ones, benzodiazepine-2,3,5-triones, isoxazoles and isoxazolines

Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm

Synthesis of dihydroimidazole tethered imidazolinethiones and their activity as novel antagonists of the nuclear retinoic acid receptor-related orphan receptors (RORs)

Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation

Peroxisome Proliferator-activated Receptor γ Ligands Regulate Myeloperoxidase Expression in Macrophages by an Estrogen-dependent Mechanism Involving the -463GA Promoter Polymorphism

Common Mode Noise Propagation and Effects in a Four-Wheel Drive Electric Vehicle

In silico identification of novel EGFR inhibitors with antiproliferative activity against cancer cells

Inhibition of IκB Kinase by a New Class of Retinoid-Related Anticancer Agents That Induce Apoptosis

Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Adamantyl Arotinoids That Inhibit IκB Kinase α and IκB Kinase β

Highly twisted adamantyl arotinoids: Synthesis, antiproliferative effects and RXR transactivation profiles

Z-FA-fmk inhibits effector caspases but not initiator caspases 8 and 10, and demonstrates that novel anticancer retinoid-related molecules induce apoptosis via the intrinsic pathway

The extrinsic and intrinsic apoptotic pathways are differentially affected by temperature upstream of mitochondrial damage

Retinoids in combination therapies for the treatment of cancer: mechanisms and perspectives

The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands

The retinoid antagonist MX781 induces clusterin expression in prostate cancer cells via heat shock factor-1 and activator protein-1 transcription factors

Leveraging atropisomerism to obtain a selective inhibitor of RET kinase with secondary activities towards EGFR mutants

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