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N-Desmethylclozapine, an Allosteric Agonist at Muscarinic 1 Receptor, Potentiates N-Methyl-D-Aspartate Receptor Activity

Proceedings of the National Academy of Sciences - PNAS, 2003-11, Vol.100 (23), p.13674-13679

2003

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L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

Antimicrobial Agents and Chemotherapy, 1995-12, Vol.39 (12), p.2602-2605

1995

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Sarafotoxin S6c: An agonist which distinguishes between endothelin receptor subtypes

Biochemical and biophysical research communications, 1991-03, Vol.175 (2), p.556-561

1991

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Molecular cloning and pharmacological characterization of the canine B1 and B2 bradykinin receptors

Biological chemistry, 2001-01, Vol.382 (1), p.123-129

2001

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Small molecule ligands for oxytocin and vasopressin receptors

Medicinal research reviews, 1997-01, Vol.17 (1), p.1-16

1997

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Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist

The Journal of pharmacology and experimental therapeutics, 1995-12, Vol.275 (3), p.1518

1995

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A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066

The Journal of pharmacology and experimental therapeutics, 1988-04, Vol.245 (1), p.32

1988

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Characterization of 5-hydroxytryptamine receptors in rat stomach fundus

The Journal of pharmacology and experimental therapeutics, 1985-12, Vol.235 (3), p.696

1985

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Discovery and development of non-peptide antagonists of peptide hormone receptors

Biochemical Society transactions, 1997-08, Vol.25 (3), p.1051-1057

1997

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Recent Advances in the Development of Oxytocin Receptor Antagonists

Current pharmaceutical design, 1996-02, Vol.2 (1), p.41-58

1996

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International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences

Pharmacological reviews, 2005-03, Vol.57 (1), p.27-77

2005

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Identification of an orally active, nonpeptidyl oxytocin antagonist

The Journal of pharmacology and experimental therapeutics, 1993-01, Vol.264 (1), p.308

1993

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Nonpeptide oxytocin antagonists: Analogs of L-371,257 with improved potency

Bioorganic & medicinal chemistry letters, 1999-05, Vol.9 (9), p.1311-1316

1999

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Nonpeptide oxytocin antagonists: Potent, orally bioavailable analogs of L-371,257 containing A 1- R-(pyridyl)ethyl ether terminus

Bioorganic & medicinal chemistry letters, 1998-11, Vol.8 (21), p.3081-3086

1998

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Receptor ligands which bind the oxytocin receptor with selectivity and high affinity. Chemical modification of a Streptomyces silvensis derived cyclic hexapeptide

Journal of medicinal chemistry, 1990-09, Vol.33 (9), p.2321-2323

1990

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Development of Orally Active Oxytocin Antagonists: Studies on 1-(1-{4-[1-(2-Methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and Related Pyridines

Journal of medicinal chemistry, 1998-06, Vol.41 (12), p.2146-2163

1998

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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

The Journal of pharmacology and experimental therapeutics, 2005-04, Vol.313 (1), p.199-206

2005

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The Role of Drug Metabolism in Drug Discovery: A Case Study in the Selection of an Oxytocin Receptor Antagonist for Development

Toxicologic pathology, 1995-03, Vol.23 (2), p.124-130

1995

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In vitro pharmacological profile of a novel structural class of oxytocin antagonists

The Journal of pharmacology and experimental therapeutics, 1991-01, Vol.256 (1), p.304

1991

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Antagonism of oxytocin in rats and pregnant rhesus monkeys by the novel cyclic hexapeptides, L-366,682 and L-366,948

The Journal of pharmacology and experimental therapeutics, 1991-03, Vol.256 (3), p.827

1991

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Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO]

The Journal of pharmacology and experimental therapeutics, 1984-09, Vol.230 (3), p.569

1984

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A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

The Journal of pharmacology and experimental therapeutics, 2004-05, Vol.309 (2), p.568-577

2004

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Tetrabenazine-induced depletion of brain monoamines: Characterization and interaction with selected antidepressants

European journal of pharmacology, 1984-07, Vol.102 (3), p.425-430

1984

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A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5

Molecular pharmacology, 2003-09, Vol.64 (3), p.731-740

2003

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Generation and characterization of a humanized bradykinin B1 receptor mouse

Biological chemistry, 2006-02, Vol.387 (2), p.195-201

2006

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N-Desmethylclozapine, an Allosteric Agonist at Muscarinic 1 Receptor, Potentiates N-Methyl-D-Aspartate Receptor Activity

L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

Sarafotoxin S6c: An agonist which distinguishes between endothelin receptor subtypes

Molecular cloning and pharmacological characterization of the canine B1 and B2 bradykinin receptors

Small molecule ligands for oxytocin and vasopressin receptors

Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist

A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066

Characterization of 5-hydroxytryptamine receptors in rat stomach fundus

Discovery and development of non-peptide antagonists of peptide hormone receptors

Recent Advances in the Development of Oxytocin Receptor Antagonists

International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences

Identification of an orally active, nonpeptidyl oxytocin antagonist

Nonpeptide oxytocin antagonists: Analogs of L-371,257 with improved potency

Nonpeptide oxytocin antagonists: Potent, orally bioavailable analogs of L-371,257 containing A 1- R-(pyridyl)ethyl ether terminus

Receptor ligands which bind the oxytocin receptor with selectivity and high affinity. Chemical modification of a Streptomyces silvensis derived cyclic hexapeptide

Development of Orally Active Oxytocin Antagonists: Studies on 1-(1-{4-[1-(2-Methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and Related Pyridines

A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

The Role of Drug Metabolism in Drug Discovery: A Case Study in the Selection of an Oxytocin Receptor Antagonist for Development

In vitro pharmacological profile of a novel structural class of oxytocin antagonists

Antagonism of oxytocin in rats and pregnant rhesus monkeys by the novel cyclic hexapeptides, L-366,682 and L-366,948

Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO]

A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

Tetrabenazine-induced depletion of brain monoamines: Characterization and interaction with selected antidepressants

A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5

Generation and characterization of a humanized bradykinin B1 receptor mouse

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