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Peptide therapeutics from venom: Current status and potential

Bioorganic & medicinal chemistry, 2018-06, Vol.26 (10), p.2738-2758

2018

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Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease

Molecular neurodegeneration, 2018-05, Vol.13 (1), p.24-24, Article 24

2018

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Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4‐mediated calcium entry in microglia

Glia, 2020-11, Vol.68 (11), p.2377-2394

2020

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Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver

PloS one, 2023-04, Vol.18 (4), p.e0283996-e0283996

2023

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Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

Toxicon (Oxford), 2012-03, Vol.59 (4), p.529-546

2012

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Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes

PloS one, 2013-10, Vol.8 (10), p.e76740

2013

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Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK

Marine drugs, 2015-01, Vol.13 (1), p.529-542

2015

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Kv1.3 Channels Are a Therapeutic Target for T Cell-Mediated Autoimmune Diseases

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (46), p.17414-17419

2006

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A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

Journal of neuroinflammation, 2017-06, Vol.14 (1), p.128-128, Article 128

2017

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Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-Dimethylsulfinylbenzhydryl

Angewandte Chemie (International ed.), 2014-03, Vol.53 (11), p.2931-2934

International ed. in English, 2014

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Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal Vaccine

mBio, 2019-11, Vol.10 (6)

2019

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KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis

Arthritis research & therapy, 2019-01, Vol.21 (1), p.6-21, Article 6

2019

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Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases

Inflammation & allergy drug targets, 2011-10, Vol.10 (5), p.313

2011

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A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation

PloS one, 2013-11, Vol.8 (11), p.e78712

2013

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Blocking KV1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma

The Journal of biological chemistry, 2014-05, Vol.289 (18), p.12623-12632

2014

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Reinvestigation of the biological activity of d-allo-ShK protein

The Journal of biological chemistry, 2017-07, Vol.292 (30), p.12599-12605

2017

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Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats

Scientific reports, 2017-06, Vol.7 (1), p.3756-11, Article 3756

2017

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Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis

Frontiers in pharmacology, 2021-09, Vol.12, p.714841-714841

2021

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Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases

Molecular pharmacology, 2005-04, Vol.67 (4), p.1369-1381

2005

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Potassium Channel Modulation by a Toxin Domain in Matrix Metalloprotease 23

The Journal of biological chemistry, 2010-03, Vol.285 (12), p.9124-9136

2010

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Bass Hepcidin Synthesis, Solution Structure, Antimicrobial Activities and Synergism, and in Vivo Hepatic Response to Bacterial Infections

The Journal of biological chemistry, 2005-03, Vol.280 (10), p.9272-9282

2005

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A Conjugate between Lqh-8/6, a Natural Peptide Analogue of Chlorotoxin, and Doxorubicin Efficiently Induces Glioma Cell Death

Biomedicines, 2022-10, Vol.10 (10), p.2605

2022

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The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites

The Journal of biological chemistry, 2003-09, Vol.278 (38), p.35869-35877

2003

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The D-Diastereomer of ShK Toxin Selectively Blocks Voltage-gated K+ Channels and Inhibits T Lymphocyte Proliferation

The Journal of biological chemistry, 2008-01, Vol.283 (2), p.988-997

2008

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Peptide therapeutics from venom: Current status and potential

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease

Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4‐mediated calcium entry in microglia

Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes

Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK

Kv1.3 Channels Are a Therapeutic Target for T Cell-Mediated Autoimmune Diseases

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-Dimethylsulfinylbenzhydryl

Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal Vaccine

KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis

Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases

A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation

Blocking KV1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma

Reinvestigation of the biological activity of d-allo-ShK protein

Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats

Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis

Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases

Potassium Channel Modulation by a Toxin Domain in Matrix Metalloprotease 23

Bass Hepcidin Synthesis, Solution Structure, Antimicrobial Activities and Synergism, and in Vivo Hepatic Response to Bacterial Infections

A Conjugate between Lqh-8/6, a Natural Peptide Analogue of Chlorotoxin, and Doxorubicin Efficiently Induces Glioma Cell Death

The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites

The D-Diastereomer of ShK Toxin Selectively Blocks Voltage-gated K+ Channels and Inhibits T Lymphocyte Proliferation

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