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Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction

CNS spectrums, 2014-04, Vol.19 (2), p.121-133

2014

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Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator

The Journal of pharmacology and experimental therapeutics, 2014-09, Vol.350 (3), p.589-604

2014

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Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism

European neuropsychopharmacology, 2014-01, Vol.24 (1), p.160-171

2014

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Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice

Pharmacology, biochemistry and behavior, 2015-08, Vol.135, p.70-82

2015

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Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function

CNS spectrums, 2016-04, Vol.21 (2), p.143-161

2016

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Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5‑HT Receptor Mechanisms and Concerted Effects of 5‑HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine

ACS chemical neuroscience, 2015-07, Vol.6 (7), p.970-986

2015

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A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression

Frontiers in neuroscience, 2015-08, Vol.9, p.279-279

2015

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Impact of metabotropic glutamate 2/3 receptor stimulation on activated dopamine release and locomotion

Psychopharmacologia, 2010-09, Vol.211 (4), p.443-455

2010

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Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants

Drug design, development and therapy, 2015-01, Vol.9, p.603-624

2015

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Vortioxetine Treatment Reverses Subchronic PCP Treatment-Induced Cognitive Impairments: A Potential Role for Serotonin Receptor-Mediated Regulation of GABA Neurotransmission

Frontiers in pharmacology, 2018-03, Vol.9, p.162

2018

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Impact of Vortioxetine on Synaptic Integration in Prefrontal-Subcortical Circuits: Comparisons with Escitalopram

Frontiers in pharmacology, 2017-10, Vol.8, p.764-764

2017

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Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents

BMC neuroscience, 2017-08, Vol.18 (1), p.56-56, Article 56

2017

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Vortioxetine Differentially Modulates MK-801-Induced Changes in Visual Signal Detection Task Performance and Locomotor Activity

Frontiers in pharmacology, 2018-09, Vol.9, p.1024-1024

2018

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Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats

The international journal of neuropsychopharmacology, 2014-10, Vol.17 (10), p.1695-1706

2014

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Treatment of cognitive dysfunction in major depressive disorder—a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin–norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine

European journal of pharmacology, 2015-04, Vol.753, p.19-31

2015

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Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission

CNS spectrums, 2016-04, Vol.21 (2), p.162-183

2016

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Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters—A rat microdialysis and electrophysiology study

European neuropsychopharmacology, 2013-02, Vol.23 (2), p.133-145

2013

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A rodent model of premenstrual dysphoria: Progesterone withdrawal induces depression-like behavior that is differentially sensitive to classes of antidepressants

Behavioural brain research, 2012-10, Vol.234 (2), p.238-247

2012

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The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT3 receptor antagonism

The international journal of neuropsychopharmacology, 2013-06, Vol.16 (5), p.1115-1127

2013

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A study of time- and sex-dependent effects of vortioxetine on rat sexual behavior: Possible roles of direct receptor modulation

Neuropharmacology, 2017-07, Vol.121, p.89-99

2017

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The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT3 receptor expressing interneurons: An in vitro study in rat hippocampus slices

Brain research, 2018-06, Vol.1689, p.1-11

2018

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The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT 3 receptor expressing interneurons: An in vitro study in rat hippocampus slices

Brain research, 2018-06, Vol.1689, p.1

2018

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The influence of NMDA and GABA(A) receptors and glutamic acid decarboxylase (GAD) activity on attention

Psychopharmacology (Berlin, Germany), 2013-01, Vol.225 (1), p.31

2013

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Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism

Journal of psychopharmacology (Oxford), 2015-10, Vol.29 (10), p.1092-1105

2015

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Chronic vortioxetine treatment in rodents modulates gene expression of neurodevelopmental and plasticity markers

European neuropsychopharmacology, 2017-02, Vol.27 (2), p.192-203

2017

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Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction

Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator

Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism

Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice

Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function

Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5‑HT Receptor Mechanisms and Concerted Effects of 5‑HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine

A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression

Impact of metabotropic glutamate 2/3 receptor stimulation on activated dopamine release and locomotion

Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants

Vortioxetine Treatment Reverses Subchronic PCP Treatment-Induced Cognitive Impairments: A Potential Role for Serotonin Receptor-Mediated Regulation of GABA Neurotransmission

Impact of Vortioxetine on Synaptic Integration in Prefrontal-Subcortical Circuits: Comparisons with Escitalopram

Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents

Vortioxetine Differentially Modulates MK-801-Induced Changes in Visual Signal Detection Task Performance and Locomotor Activity

Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats

Treatment of cognitive dysfunction in major depressive disorder—a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin–norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine

Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission

Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters—A rat microdialysis and electrophysiology study

A rodent model of premenstrual dysphoria: Progesterone withdrawal induces depression-like behavior that is differentially sensitive to classes of antidepressants

The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT3 receptor antagonism

A study of time- and sex-dependent effects of vortioxetine on rat sexual behavior: Possible roles of direct receptor modulation

The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT3 receptor expressing interneurons: An in vitro study in rat hippocampus slices

The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT 3 receptor expressing interneurons: An in vitro study in rat hippocampus slices

The influence of NMDA and GABA(A) receptors and glutamic acid decarboxylase (GAD) activity on attention

Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism

Chronic vortioxetine treatment in rodents modulates gene expression of neurodevelopmental and plasticity markers

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