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Ligand binding at the protein–lipid interface: strategic considerations for drug design

Nature reviews. Drug discovery, 2021-09, Vol.20 (9), p.710-722

2021

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Bacterial Voltage-Gated Sodium Channels (BacNaVs) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart

Journal of molecular biology, 2015-01, Vol.427 (1), p.3-30

2015

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The crystal structure of a voltage-gated sodium channel

Nature (London), 2011-07, Vol.475 (7356), p.353-358

2011

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The hitchhiker's guide to the voltage-gated sodium channel galaxy

The Journal of general physiology, 2016-01, Vol.147 (1), p.1-24

2016

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Crystal structure of the plant dual-affinity nitrate transporter NRT1.1

Nature (London), 2014-03, Vol.507 (7490), p.73-77

2014

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An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor

Cell, 2018-08, Vol.174 (5), p.1158-1171.e19

2018

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Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

Cell, 2019-02, Vol.176 (4), p.702-715.e14

2019

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Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

Nature (London), 2012-06, Vol.486 (7401), p.135-139

2012

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Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

Nature (London), 2014-01, Vol.505 (7481), p.56-61

2014

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Catalysis of Na⁺ permeation in the bacterial sodium channel NaVAb

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (28), p.11331-11336

2013

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Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

Nature communications, 2022-03, Vol.13 (1), p.1416-1416, Article 1416

2022

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Structure of the core human NADPH oxidase NOX2

Nature communications, 2022-10, Vol.13 (1), p.6079-11, Article 6079

2022

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Structural basis for dual-mode inhibition of the ABC transporter MsbA

Nature (London), 2018-05, Vol.557 (7704), p.196-201

2018

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The structure and regulation of magnesium selective ion channels

Biochimica et biophysica acta, 2013-11, Vol.1828 (11), p.2778-2792

2013

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Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung

Nature (London), 2015-12, Vol.528 (7580), p.127-131

2015

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Structure of the essential inner membrane lipopolysaccharide–PbgA complex

Nature (London), 2020-08, Vol.584 (7821), p.479-483

2020

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Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

PLoS genetics, 2018-11, Vol.14 (11), p.e1007427-e1007427

2018

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Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8

Nature communications, 2023-12, Vol.14 (1), p.7940-7940, Article 7940

2023

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A structural basis for Mg2+ homeostasis and the CorA translocation cycle

The EMBO journal, 2006-08, Vol.25 (16), p.3762-3773

2006

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The discovery and structural basis of two distinct state-dependent inhibitors of BamA

Nature communications, 2024-10, Vol.15 (1), p.8718-15, Article 8718

2024

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An Iris-Like Mechanism of Pore Dilation in the CorA Magnesium Transport System

Biophysical journal, 2010-03, Vol.98 (5), p.784-792

2010

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Structural asymmetry in the magnesium channel CorA points to sequential allosteric regulation

Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (46), p.18809-18814

2012

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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability

mAbs, 2024, Vol.16 (1), p.2309685-2309685

2024

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Progress in understanding slow inactivation speeds up

The Journal of general physiology, 2018-09, Vol.150 (9), p.1235-1238

Payandeh, Jian

2018

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Ligand binding at the protein–lipid interface: strategic considerations for drug design

Bacterial Voltage-Gated Sodium Channels (BacNaVs) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart

The crystal structure of a voltage-gated sodium channel

The hitchhiker's guide to the voltage-gated sodium channel galaxy

Crystal structure of the plant dual-affinity nitrate transporter NRT1.1

An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

Catalysis of Na⁺ permeation in the bacterial sodium channel NaVAb

Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

Structure of the core human NADPH oxidase NOX2

Structural basis for dual-mode inhibition of the ABC transporter MsbA

The structure and regulation of magnesium selective ion channels

Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung

Structure of the essential inner membrane lipopolysaccharide–PbgA complex

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8

A structural basis for Mg2+ homeostasis and the CorA translocation cycle

Massive antibody discovery used to probe structure-function relationships of the essential outer membrane protein LptD

The discovery and structural basis of two distinct state-dependent inhibitors of BamA

An Iris-Like Mechanism of Pore Dilation in the CorA Magnesium Transport System

Structural asymmetry in the magnesium channel CorA points to sequential allosteric regulation

Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability

Progress in understanding slow inactivation speeds up

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