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The Evolving Druggability and Developability Space: Chemically Modified New Modalities and Emerging Small Molecules

The AAPS journal, 2020-01, Vol.22 (2), p.21, Article 21

2020

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Identification of a Multi-Component Formulation for Intestinal Delivery of a GLP-1/Glucagon Co-agonist Peptide

Pharmaceutical research, 2022-10, Vol.39 (10), p.2555-2567

2022

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Modulating target engagement of small molecules via drug delivery: approaches and applications in drug discovery and development

Drug discovery today, 2021-03, Vol.26 (3), p.713-723

2021

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Mesomorphous versus traces of crystallinity: The itraconazole example

Thermochimica acta, 2013-12, Vol.574, p.133-139

2013

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Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs

Journal of medicinal chemistry, 1993-06, Vol.36 (13), p.1893-1901

1993

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Correlation of in vivo topical efficacies with in vitro predictions using acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice: an evaluation of the predictive value of the [formula omitted] concept

Antiviral research, 1996, Vol.29 (2), p.279-286

1996

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Correlation of in vivo topical efficacies with in vitro predictions using acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice : an evaluation of the predictive value of the C concept

Antiviral research, 1996-03, Vol.29 (2-3), p.279-286

1996

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Development of an improved fluidization segregation tester for use with pharmaceutical powders

Pharmaceutical Technology, 2006-12, Vol.30 (12), p.54-64

2006

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Redox reactive reagents inhibiting and inactivating choline acetyltransferase

Biochemical and biophysical research communications, 1991-03, Vol.175 (2), p.407-413

1991

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Discovery of 1‑(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3‑d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells

Journal of medicinal chemistry, 2015-05, Vol.58 (10), p.4165-4179

2015

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Abstract DDT02-02: Identification of LY3009120 as a pan inhibitor of Raf isoforms and dimers with minimal paradoxical activation and activities against BRaf or Ras mutant tumor cells

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.DDT02-02-DDT02-02

2014

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The Evolving Druggability and Developability Space: Chemically Modified New Modalities and Emerging Small Molecules

Identification of a Multi-Component Formulation for Intestinal Delivery of a GLP-1/Glucagon Co-agonist Peptide

Modulating target engagement of small molecules via drug delivery: approaches and applications in drug discovery and development

Mesomorphous versus traces of crystallinity: The itraconazole example

Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs

Correlation of in vivo topical efficacies with in vitro predictions using acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice: an evaluation of the predictive value of the [formula omitted] concept

Correlation of in vivo topical efficacies with in vitro predictions using acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice : an evaluation of the predictive value of the C concept

Development of an improved fluidization segregation tester for use with pharmaceutical powders

Redox reactive reagents inhibiting and inactivating choline acetyltransferase

Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers

Discovery of 1‑(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3‑d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells

Abstract DDT02-02: Identification of LY3009120 as a pan inhibitor of Raf isoforms and dimers with minimal paradoxical activation and activities against BRaf or Ras mutant tumor cells

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