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Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation

PloS one, 2010-09, Vol.5 (9), p.e12733

2010

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In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization

Nucleic acids research, 2015-10, Vol.43 (18), p.8638-8650

2015

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Outcomes of the European Federation of Pharmaceutical Industries and Associations Oligonucleotide Working Group Survey on Nonclinical Practices and Regulatory Expectations for Therapeutic Oligonucleotide Safety Assessment

Nucleic acid therapeutics, 2021-02, Vol.31 (1), p.7-20

2021

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Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses

Advanced drug delivery reviews, 2014-05, Vol.71, p.15-33

2014

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Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs

Molecular therapy. Nucleic acids, 2017-09, Vol.8, p.383-394

2017

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The Opportunity of Modern High-Toughness Technical Ceramics for Undersea Systems

Marine Technology Society journal, 2021-01, Vol.55 (1), p.50-55

2021

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Clinical expert panel on monitoring potential lung toxicity of inhaled oligonucleotides: consensus points and recommendations

Nucleic acid therapeutics, 2012-08, Vol.22 (4), p.246-254

2012

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Lightweight modular construction of school classrooms, reverberation time prediction versus field testing

The Journal of the Acoustical Society of America, 2023-10, Vol.154 (4_supplement), p.A214-A214

Parry-Jones, Joel

2023

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Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis

Molecular therapy. Nucleic acids, 2013-01, Vol.2 (1), p.e65-e65, Article e65

2013

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Pivotal Role for Two Electron Reduction in 2,3-Dimethoxy-1,4-naphthoquinone and 2-Methyl-1,4-naphthoquinone Metabolism and Kinetics in Vivo That Prevents Liver Redox Stress

Chemical research in toxicology, 2009-04, Vol.22 (4), p.717-725

2009

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Assessing unintended hybridization-induced biological effects of oligonucleotides

Nature biotechnology, 2012-10, Vol.30 (10), p.920-923

2012

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Understanding the behavior of nanoparticulate drug delivery systems in vivo: particle disposition patterns, toxicologic implications and effective drug development

Toxicology letters, 2013-08, Vol.221, p.S42-S42

2013

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Anti-inflammatory Disease Therapies: Challenges and Strategies in Drug Development

Toxicologic pathology, 2012-01, Vol.40 (1), p.122-125

2012

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Role of miRNA species and altered mRNA translation in doxorubicin and quinone mediated cardiotoxicity in vivo and in vitro

Toxicology letters, 2009-09, Vol.189, p.S93-S93

2009

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Differences in metabolism and GSH conjugation of 2-methyl-1,4-naphthoquinone in vivo and in vitro suggest oversensitivity for oxidative stress-induced toxicity in vitro

Toxicology letters, 2009-09, Vol.189, p.S118-S119

2009

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Two electron reduction of 2,3-dimethoxy-1,4-naphthoquinone metabolism in vivo prevents redox stress but interaction with the electron transport chain may be a mechanism of toxicity

Toxicology letters, 2009-09, Vol.189, p.S119-S119

2009

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A quinone sensitive phenotype results from reduced Pim3 expression in rat hepatocytes

Toxicology letters, 2006-09, Vol.164, p.S251-S251

2006

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Pharmacological Characterization of a Novel ENaC[alpha] siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis

Molecular therapy. Nucleic acids, 2013-01, Vol.2, p.e65

2013

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Transcriptomic assessment of quinone mediated hepatic oxidative stress

Parry, Joel D

2007

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Transcriptomic assessment of quinone mediated hepatic oxidative stress

Parry, Joel D

2007

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Broken chocolate: biomarkers as a method for delivering cocoa supply chain visibility

Supply chain management, 2022-11, Vol.27 (6), p.728-741

2022

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Assessing long-term conservation impacts on adaptive capacity in a flagship community-based natural resources management area in Botswana

Ecology and society, 2023-12, Vol.28 (4), p.12, Article art12

2023

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Strain-specific genetics, anatomy and function of enteric neural serotonergic pathways in inbred mice

The Journal of physiology, 2009-02, Vol.587 (3), p.567-586

2009

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VPAC1 receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum

American journal of physiology: Gastrointestinal and liver physiology, 2014-05, Vol.306 (9), p.G748-G758

2014

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A novel mouse model of Duchenne muscular dystrophy carrying a multi-exonic Dmd deletion exhibits progressive muscular dystrophy and early-onset cardiomyopathy

Disease models & mechanisms, 2020-09, Vol.13 (9)

2020

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Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation

In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization

Outcomes of the European Federation of Pharmaceutical Industries and Associations Oligonucleotide Working Group Survey on Nonclinical Practices and Regulatory Expectations for Therapeutic Oligonucleotide Safety Assessment

Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses

Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs

The Opportunity of Modern High-Toughness Technical Ceramics for Undersea Systems

Clinical expert panel on monitoring potential lung toxicity of inhaled oligonucleotides: consensus points and recommendations

Lightweight modular construction of school classrooms, reverberation time prediction versus field testing

Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis

Pivotal Role for Two Electron Reduction in 2,3-Dimethoxy-1,4-naphthoquinone and 2-Methyl-1,4-naphthoquinone Metabolism and Kinetics in Vivo That Prevents Liver Redox Stress

Assessing unintended hybridization-induced biological effects of oligonucleotides

Understanding the behavior of nanoparticulate drug delivery systems in vivo: particle disposition patterns, toxicologic implications and effective drug development

Anti-inflammatory Disease Therapies: Challenges and Strategies in Drug Development

Role of miRNA species and altered mRNA translation in doxorubicin and quinone mediated cardiotoxicity in vivo and in vitro

Differences in metabolism and GSH conjugation of 2-methyl-1,4-naphthoquinone in vivo and in vitro suggest oversensitivity for oxidative stress-induced toxicity in vitro

Two electron reduction of 2,3-dimethoxy-1,4-naphthoquinone metabolism in vivo prevents redox stress but interaction with the electron transport chain may be a mechanism of toxicity

A quinone sensitive phenotype results from reduced Pim3 expression in rat hepatocytes

Pharmacological Characterization of a Novel ENaC[alpha] siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis

Transcriptomic assessment of quinone mediated hepatic oxidative stress

Transcriptomic assessment of quinone mediated hepatic oxidative stress

Broken chocolate: biomarkers as a method for delivering cocoa supply chain visibility

Assessing long-term conservation impacts on adaptive capacity in a flagship community-based natural resources management area in Botswana

Strain-specific genetics, anatomy and function of enteric neural serotonergic pathways in inbred mice

VPAC1 receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum

A novel mouse model of Duchenne muscular dystrophy carrying a multi-exonic Dmd deletion exhibits progressive muscular dystrophy and early-onset cardiomyopathy

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