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Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

ACS chemical biology, 2015-04, Vol.10 (4), p.1094-1098

2015

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Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors

Biochemical journal, 2014-06, Vol.460 (2), p.211-222

2014

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Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.1130-1152

2018

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A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS

Molecular bioSystems, 2015-01, Vol.11 (10), p.2709-2712

2015

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Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3–9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.7669-7683

2019

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Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Chembiochem : a European journal of chemical biology, 2016-10, Vol.17 (20), p.1925-1930

2016

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Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA)

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3094-3108

2017

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Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4882-4884

2009

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Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1543-1547

2010

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Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity

The Journal of pharmacology and experimental therapeutics, 2010-06, Vol.333 (3), p.707

2010

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Demonstration of a Multikilogram-Scale Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative

Organic process research & development, 2024-06, Vol.28 (6), p.2168-2176

2024

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.326-342

2021

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Discovery of + (2 -{4 -[2 -(5,6,7,8 -tetrahydro -1,8 -naphthyridin -2-yl )ethoxy ]phenyl} -cyclopropyl )acetic acid as potent and selective αvβ3 inhibitor : Design, synthesis, and optimization

Bioorganic & medicinal chemistry, 2007-05, Vol.15 (10), p.3390-3412

2007

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Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma

Journal of allergy and clinical immunology, 2017-01, Vol.139 (1), p.72-81.e1

2017

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A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpSElectronic supplementary information (ESI) available: Additional experimental details, including compound synthesis, analytical data and labelling procedures. See DOI: 10.1039/c5mb00288e

2015-09

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Porphyrins with exocyclic rings. Part 19: Efficient syntheses of phenanthrolinoporphyrins

Tetrahedron, 2005-12, Vol.61 (49), p.11601-11614

2005

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Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization

Bioorganic & medicinal chemistry, 2007-05, Vol.15 (10), p.3390-3412

2007

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Porphyrins with Exocyclic Rings. Part 19. Efficient Syntheses of Phenanthrolinoporphyrins

ChemInform, 2006-01, Vol.37 (5), p.no-no

2006

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Estimating HIV Disclosure and Its Impact on Social Relations: A Cross-Sectional Study in Gujarat, India

National journal of community medicine, 2024-07, Vol.15 (7), p.553-558

2024

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Secondary Glioblastoma with Primitive Neuronal Component

Neurology India, 2022-01, Vol.70 (1), p.459-461

2022

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Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4800-4811

2016

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Frailty Characteristics Predict Respiratory Failure in Patients Undergoing Tracheobronchoplasty

The Annals of thoracic surgery, 2018-09, Vol.106 (3), p.836-841

2018

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A Randomized Controlled Trial of a CPR and Intubation Video Decision Support Tool for Hospitalized Patients

Journal of general internal medicine : JGIM, 2015-08, Vol.30 (8), p.1071-1080

2015

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Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors

Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS

Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3–9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA)

Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning

Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency

Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode

Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity

Demonstration of a Multikilogram-Scale Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Discovery of + (2 -{4 -[2 -(5,6,7,8 -tetrahydro -1,8 -naphthyridin -2-yl )ethoxy ]phenyl} -cyclopropyl )acetic acid as potent and selective αvβ3 inhibitor : Design, synthesis, and optimization

Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpSElectronic supplementary information (ESI) available: Additional experimental details, including compound synthesis, analytical data and labelling procedures. See DOI: 10.1039/c5mb00288e

Porphyrins with exocyclic rings. Part 19: Efficient syntheses of phenanthrolinoporphyrins

Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization

Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective α vβ 3 inhibitor: Design, synthesis, and optimization

Porphyrins with Exocyclic Rings. Part 19. Efficient Syntheses of Phenanthrolinoporphyrins

Estimating HIV Disclosure and Its Impact on Social Relations: A Cross-Sectional Study in Gujarat, India

Secondary Glioblastoma with Primitive Neuronal Component

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

Frailty Characteristics Predict Respiratory Failure in Patients Undergoing Tracheobronchoplasty

A Randomized Controlled Trial of a CPR and Intubation Video Decision Support Tool for Hospitalized Patients

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