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TC-5619: An alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

Biochemical pharmacology, 2009-10, Vol.78 (7), p.803-812

2009

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Imaging of cerebral α4β2 nicotinic acetylcholine receptors with (−)-[18F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain

NeuroImage (Orlando, Fla.), 2016-11, Vol.141, p.71-80

2016

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Impact of modulation of the α7 nicotinic acetylcholine receptor on nicotine reward in the mouse conditioned place preference test

Psychopharmacology, 2019-12, Vol.236 (12), p.3593-3599

2019

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Comparative pharmacology of rat and human alpha 7 nAChR conducted with net charge analysis

British journal of pharmacology, 2002-09, Vol.137 (1), p.49-61

2002

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Region‐specific effects of N,N′‐dodecane‐1,12‐diyl‐bis‐3‐picolinium dibromide on nicotine‐induced increase in extracellular dopamine in vivo

British journal of pharmacology, 2008-02, Vol.153 (4), p.792-804

2008

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Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit

Molecular pharmacology, 1994-01, Vol.45 (1), p.142-149

1994

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The correction of alpha7 nicotinic acetylcholine receptor concentration-response relationships in Xenopus oocytes

Neuroscience letters, 1998-11, Vol.256 (3), p.163-166

1998

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Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes

The Journal of pharmacology and experimental therapeutics, 2001-05, Vol.297 (2), p.646

2001

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The kinetic properties of neuronal nicotinic receptors : genetic basis of functional diversity

Progress in neurobiology, 1993-10, Vol.41 (4), p.509-531

PAPKE, R. L

1993

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Activity of α7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (8), p.1849-1853

2004

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α7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation

Neuroscience, 2007-03, Vol.145 (1), p.314-322

2007

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Rare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors

The Journal of pharmacology and experimental therapeutics, 2014-03, Vol.348 (3), p.410

2014

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The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors

The Journal of physiology, 1991-08, Vol.440 (1), p.95-112

1991

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Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain

British journal of pharmacology, 1999-07, Vol.127 (6), p.1337-1348

1999

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2-(2-Piperidyl)- and 2-(2-Pyrrolidyl)chromans as Nicotine Agonists: Synthesis and Preliminary Pharmacological Characterization

Journal of medicinal chemistry, 2001-12, Vol.44 (26), p.4704-4715

2001

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A novel nicotinic agonist facilitates induction of long-term potentiation in the rat hippocampus

Neuroscience letters, 1994-02, Vol.168 (1), p.130-134

1994

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alpha 7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation

Neuroscience, 2007-03, Vol.145 (1), p.314-322

2007

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An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype

Neuroscience letters, 1996-08, Vol.213 (3), p.201-204

1996

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Inhibition of Wild-Type and Mutant Neuronal Nicotinic Acetylcholine Receptors by Local Anesthetics

Molecular pharmacology, 2001-12, Vol.60 (6), p.1365-1374

2001

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Nicotinic Receptors on Local Circuit Neurons in Dentate Gyrus: A Potential Role in Regulation of Granule Cell Excitability

Journal of neurophysiology, 2003-06, Vol.89 (6), p.3018-3028

2003

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Activation and inhibition of native neuronal alpha-bungarotoxin-sensitive nicotinic ACh receptors

Brain research, 2002-09, Vol.948 (1), p.33-46

2002

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Regulation of Neuronal Function by Choline and 4OH-GTS-21 Through alpha 7 Nicotinic Receptors

Journal of neurophysiology, 2003-04, Vol.89 (4), p.1797-1806

2003

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Inhibition of nicotinic acetylcholine receptors by bis (2,2,6,6-tetramethyl- 4-piperidinyl) sebacate (Tinuvin 770), an additive to medical plastics

The Journal of pharmacology and experimental therapeutics, 1994-02, Vol.268 (2), p.718

1994

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Differentiation of Ionic Currents in CNS Progenitor Cells: Dependence upon Substrate Attachment and Epidermal Growth Factor

Experimental neurology, 1996-08, Vol.140 (2), p.206-217

1996

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The amino terminal half of the nicotinic beta-subunit extracellular domain regulates the kinetics of inhibition by neuronal bungarotoxin

Proceedings of the Royal Society. B, Biological sciences, 1993-05, Vol.252 (1334), p.141

1993

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TC-5619: An alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

Imaging of cerebral α4β2 nicotinic acetylcholine receptors with (−)-[18F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain

Impact of modulation of the α7 nicotinic acetylcholine receptor on nicotine reward in the mouse conditioned place preference test

Comparative pharmacology of rat and human alpha 7 nAChR conducted with net charge analysis

Region‐specific effects of N,N′‐dodecane‐1,12‐diyl‐bis‐3‐picolinium dibromide on nicotine‐induced increase in extracellular dopamine in vivo

Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit

The correction of alpha7 nicotinic acetylcholine receptor concentration-response relationships in Xenopus oocytes

Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes

The kinetic properties of neuronal nicotinic receptors : genetic basis of functional diversity

Activity of α7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes

α7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation

Rare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors

The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors

Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain

2-(2-Piperidyl)- and 2-(2-Pyrrolidyl)chromans as Nicotine Agonists: Synthesis and Preliminary Pharmacological Characterization

A novel nicotinic agonist facilitates induction of long-term potentiation in the rat hippocampus

alpha 7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation

An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype

Inhibition of Wild-Type and Mutant Neuronal Nicotinic Acetylcholine Receptors by Local Anesthetics

Nicotinic Receptors on Local Circuit Neurons in Dentate Gyrus: A Potential Role in Regulation of Granule Cell Excitability

Activation and inhibition of native neuronal alpha-bungarotoxin-sensitive nicotinic ACh receptors

Regulation of Neuronal Function by Choline and 4OH-GTS-21 Through alpha 7 Nicotinic Receptors

Inhibition of nicotinic acetylcholine receptors by bis (2,2,6,6-tetramethyl- 4-piperidinyl) sebacate (Tinuvin 770), an additive to medical plastics

Differentiation of Ionic Currents in CNS Progenitor Cells: Dependence upon Substrate Attachment and Epidermal Growth Factor

The amino terminal half of the nicotinic beta-subunit extracellular domain regulates the kinetics of inhibition by neuronal bungarotoxin

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