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An analysis of the limitations and uncertainties of in vivo developmental neurotoxicity testing and assessment to identify the potential for alternative approaches

Reproductive toxicology (Elmsford, N.Y.), 2020-09, Vol.96, p.327-336

2020

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Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens

Archives of toxicology, 2020-08, Vol.94 (8), p.2899-2923

2020

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The Cell Transformation Assay: A Historical Assessment of Current Knowledge of Applications in an Integrated Approach to Testing and Assessment for Non-Genotoxic Carcinogens

International journal of molecular sciences, 2023-03, Vol.24 (6), p.5659

2023

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Analyses of Transcriptomics Cell Signalling for Pre-Screening Applications in the Integrated Approach for Testing and Assessment of Non-Genotoxic Carcinogens

International journal of molecular sciences, 2022-11, Vol.23 (21), p.12718

2022

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Development of Integrated Approaches to Testing and Assessment (IATA) case studies on developmental neurotoxicity (DNT) risk assessment

EFSA journal, 2021-06, Vol.19 (6), p.n/a

2021

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A developmental neurotoxicity adverse outcome pathway (DNT‐AOP) with voltage gate sodium channel (VGSC) inhibition as a molecular initiating event (MiE)

EFSA journal, 2024-08, Vol.22 (8), p.e8954-n/a

2024

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Limitations and uncertainties of acute fish toxicity assessments can be reduced using alternative methods_suppl

ALTEX, alternatives to animal experimentation, 2020

Paparella, Martin

2020

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Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites

EFSA journal, 2024-05, Vol.22 (5), p.e8759-n/a

2024

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OECD workshop consensus report: Ethical considerations with respect to human derived products, specifically human serum, in OECD test guidelines

Frontiers in toxicology, 2023-02, Vol.5, p.1140698-1140698

2023

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Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs

ALTEX, 2023-01, Vol.40 (2), p.337–340

2023

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A Human Cell-based Assay to Assess the Induction of Vasculature Formation for Non-genotoxic Carcinogenicity Testing Purposes: A Pilot Study

Alternatives to laboratory animals, 2023-05, Vol.51 (3), p.188-203

2023

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Uncertainties of testing methods: What do we (want to) know about carcinogenicity?

ALTEX, alternatives to animal experimentation, 2017, Vol.34 (2), p.235-252

2017

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Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review

ALTEX, alternatives to animal experimentation, 2024-01, Vol.41 (2), p.248

2024

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Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

Toxicology and applied pharmacology, 2018-09, Vol.354, p.3-6

2018

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International regulatory needs for development of an IATA for non-genotoxic carcinogenic chemical substances

ALTEX, alternatives to animal experimentation, 2016-01, Vol.33 (4), p.359

2016

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The transformics assay: first steps for the development of an integrated approach to investigate the malignant cell transformation in vitro

Carcinogenesis (New York), 2018-07, Vol.39 (7), p.955-967

2018

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Limitations and uncertainties of acute fish toxicity assessments can be reduced using alternative methods

ALTEX, alternatives to animal experimentation, 2021-01, Vol.38 (1), p.20

2021

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Big Question to Developing Solutions: A Decade of Progress in the Development of Aquatic New Approach Methodologies from 2012 to 2022

Environmental toxicology and chemistry, 2024-03, Vol.43 (3), p.559-574

2024

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In vitro evaluation of the carcinogenic potential of perfluorinated chemicals

ALTEX, alternatives to animal experimentation, 2024-01, Vol.41 (3), p.439

2024

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Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals

ALTEX, 2024-01, Vol.41 (1), p.76

2024

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Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells

ALTEX, alternatives to animal experimentation, 2019-01, Vol.36 (2), p.231

2019

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The transformics assay: first steps for the development of an integrated approach to investigate the malignant cell transformation in vitro

Carcinogenesis (New York), 2018-07, Vol.39 (7), p.968-968

2018

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Easy-MODA: Simplifying standardised registration of scientific simulation workflows through MODA template guidelines powered by the Enalos Cloud Platform

Computational and structural biotechnology journal, 2024-12, Vol.25, p.256-268

2024

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Uncertainty of testing methods--what do we (want to) know?

ALTEX, alternatives to animal experimentation, 2013, Vol.30 (2), p.131-144

2013

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An analysis of the limitations and uncertainties of in vivo developmental neurotoxicity testing and assessment to identify the potential for alternative approaches

Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens

The Cell Transformation Assay: A Historical Assessment of Current Knowledge of Applications in an Integrated Approach to Testing and Assessment for Non-Genotoxic Carcinogens

Analyses of Transcriptomics Cell Signalling for Pre-Screening Applications in the Integrated Approach for Testing and Assessment of Non-Genotoxic Carcinogens

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

Development of Integrated Approaches to Testing and Assessment (IATA) case studies on developmental neurotoxicity (DNT) risk assessment

A developmental neurotoxicity adverse outcome pathway (DNT‐AOP) with voltage gate sodium channel (VGSC) inhibition as a molecular initiating event (MiE)

Limitations and uncertainties of acute fish toxicity assessments can be reduced using alternative methods_suppl

Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites

OECD workshop consensus report: Ethical considerations with respect to human derived products, specifically human serum, in OECD test guidelines

Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs

A Human Cell-based Assay to Assess the Induction of Vasculature Formation for Non-genotoxic Carcinogenicity Testing Purposes: A Pilot Study

Uncertainties of testing methods: What do we (want to) know about carcinogenicity?

Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

International regulatory needs for development of an IATA for non-genotoxic carcinogenic chemical substances

The transformics assay: first steps for the development of an integrated approach to investigate the malignant cell transformation in vitro

Limitations and uncertainties of acute fish toxicity assessments can be reduced using alternative methods

Big Question to Developing Solutions: A Decade of Progress in the Development of Aquatic New Approach Methodologies from 2012 to 2022

In vitro evaluation of the carcinogenic potential of perfluorinated chemicals

Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals

Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells

The transformics assay: first steps for the development of an integrated approach to investigate the malignant cell transformation in vitro

Easy-MODA: Simplifying standardised registration of scientific simulation workflows through MODA template guidelines powered by the Enalos Cloud Platform

Uncertainty of testing methods--what do we (want to) know?

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