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HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

The Journal of experimental medicine, 2020-07, Vol.217 (7)

2020

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Immune Sensing of DNA

Immunity (Cambridge, Mass.), 2013-05, Vol.38 (5), p.870-880

2013

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Constitutive immune mechanisms: mediators of host defence and immune regulation

Nature reviews. Immunology, 2021-03, Vol.21 (3), p.137

2021

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DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer

Nature reviews. Immunology, 2019-03, Vol.19 (3), p.141

2019

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Activation and regulation of DNA-driven immune responses

Microbiology and molecular biology reviews, 2015-06, Vol.79 (2), p.225-241

Paludan, Søren R

2015

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An IKBKE variant conferring functional cGAS/STING pathway deficiency and susceptibility to recurrent HSV-2 meningitis

JCI insight, 2023-11, Vol.8 (21)

2023

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IFI16 is an innate immune sensor for intracellular DNA

Nature immunology, 2010-11, Vol.11 (11), p.997

2010

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Innate immunological pathways in COVID-19 pathogenesis

Science immunology, 2022-01, Vol.7 (67), p.eabm5505

2022

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Recognition of herpesviruses by the innate immune system

Nature reviews. Immunology, 2011-02, Vol.11 (2), p.143

2011

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IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (48), p.E4571-E4580

2013

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Microglia and amyloid plaque formation in Alzheimer's disease – Evidence, possible mechanisms, and future challenges

Journal of neuroimmunology, 2024-05, Vol.390, p.578342-578342, Article 578342

2024

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The presence of serum anti‐SARS‐CoV‐2 IgA appears to protect primary health care workers from COVID‐19

European journal of immunology, 2022-05, Vol.52 (5), p.800-809

2022

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Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS

Nature communications, 2016-11, Vol.7 (1), p.13348-13348, Article 13348

2016

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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

Nature immunology, 2012-08, Vol.13 (8), p.737

2012

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Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

Hepatology (Baltimore, Md.), 2016-09, Vol.64 (3), p.746-759

2016

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Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

The EMBO journal, 2018-04, Vol.37 (8), p.n/a

2018

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STING is ESCRTed to degradation by microautophagy

Nature cell biology, 2023-03, Vol.25 (3), p.379

2023

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Molecular requirements for sensing of intracellular microbial nucleic acids by the innate immune system

Cytokine (Philadelphia, Pa.), 2017-10, Vol.98, p.4-14

2017

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Constitutive and latent immune mechanisms exert ‘silent’ control of virus infections in the central nervous system

Current opinion in immunology, 2021-10, Vol.72, p.158-166

2021

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Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses

Journal of Virology, 2006-05, Vol.80 (10), p.5059-5064

2006

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An Important Role for Type III Interferon (IFN-{lambda}/IL-28) in TLR-Induced Antiviral Activity

The Journal of immunology (1950), 2008-02, Vol.180 (4), p.2474-2485

2008

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Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

Nature medicine, 2009-01, Vol.15 (1), p.97-103

2009

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cGAS is activated by DNA in a length‐dependent manner

EMBO reports, 2017-10, Vol.18 (10), p.1707-1715

2017

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A truncated reverse transcriptase enhances prime editing by split AAV vectors

Molecular therapy, 2022-09, Vol.30 (9), p.2942-2951

2022

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Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway

The EMBO journal, 2014-08, Vol.33 (15), p.1654-1666

2014

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HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

Immune Sensing of DNA

Constitutive immune mechanisms: mediators of host defence and immune regulation

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer

Activation and regulation of DNA-driven immune responses

An IKBKE variant conferring functional cGAS/STING pathway deficiency and susceptibility to recurrent HSV-2 meningitis

IFI16 is an innate immune sensor for intracellular DNA

Innate immunological pathways in COVID-19 pathogenesis

Recognition of herpesviruses by the innate immune system

IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

Microglia and amyloid plaque formation in Alzheimer's disease – Evidence, possible mechanisms, and future challenges

The presence of serum anti‐SARS‐CoV‐2 IgA appears to protect primary health care workers from COVID‐19

Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

STING is ESCRTed to degradation by microautophagy

Molecular requirements for sensing of intracellular microbial nucleic acids by the innate immune system

Constitutive and latent immune mechanisms exert ‘silent’ control of virus infections in the central nervous system

Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses

An Important Role for Type III Interferon (IFN-{lambda}/IL-28) in TLR-Induced Antiviral Activity

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

cGAS is activated by DNA in a length‐dependent manner

A truncated reverse transcriptase enhances prime editing by split AAV vectors

Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway

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