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Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19

Current opinion in virology, 2021-10, Vol.50, p.17-22

2021

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Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

Antimicrobial agents and chemotherapy, 2018-08, Vol.62 (8)

2018

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The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection

Antiviral research, 2019-11, Vol.171, p.104597-104597, Article 104597

2019

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SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

Nature communications, 2022-07, Vol.13 (1), p.4416-4416, Article 4416

2022

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Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

Nature communications, 2023-08, Vol.14 (1), p.4731-4731, Article 4731

2023

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Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (20), p.7293-7297

2008

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Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2

Antimicrobial agents and chemotherapy, 2021-05, Vol.65 (5)

2021

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Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies

The Journal of infectious diseases, 2010-11, Vol.202 (10), p.1492-1499

2010

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Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses

Antimicrobial Agents and Chemotherapy, 2007-11, Vol.51 (11), p.4118-4124

2007

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Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model

Translational research : the journal of laboratory and clinical medicine, 2020-04, Vol.218, p.16-28

2020

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Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Journal of virology, 2019-12, Vol.93 (24)

2019

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Small-Molecule Antiviral β-d- N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Journal of virology, 2019-12, Vol.93 (24)

2019

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β-d- N 4 -Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome

Journal of virology, 2018-02, Vol.92 (3)

2018

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Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections

Antimicrobial Agents and Chemotherapy, 2007-10, Vol.51 (10), p.3505-3509

2007

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Development of Hexadecyloxypropyl Tenofovir (CMX157) for Treatment of Infection Caused by Wild-Type and Nucleoside/Nucleotide-Resistant HIV

Antimicrobial Agents and Chemotherapy, 2010-07, Vol.54 (7), p.2901-2909

2010

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Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC)

Accounts of chemical research, 2016-10, Vol.49 (10), p.2091-2098

2016

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4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication

Science (American Association for the Advancement of Science), 2022-01, Vol.375 (6577), p.161-167

2022

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Analysis of Ribonucleotide 5'-Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-Dependent RNA Polymerase by Using Nonradioactive Polymerase Assays

Antimicrobial agents and chemotherapy, 2017-03, Vol.61 (3)

2017

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The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N4-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection

Antiviral research, 2023-01, Vol.209, p.105453-105453, Article 105453

2023

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Analysis of the Potential for N 4 -Hydroxycytidine To Inhibit Mitochondrial Replication and Function

Antimicrobial agents and chemotherapy, 2020-01, Vol.64 (2)

2020

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Analysis of the Potential for N4-Hydroxycytidine To Inhibit Mitochondrial Replication and Function

Antimicrobial agents and chemotherapy, 2020-01, Vol.64 (2)

2020

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Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine

Journal of virology, 2024-03, Vol.98 (4), p.e0013224

2024

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Lassa and Ebola virus inhibitors identified using minigenome and recombinant virus reporter systems

Antiviral research, 2016-12, Vol.136 (C), p.9-18

2016

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4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

PLoS pathogens, 2023-04, Vol.19 (4), p.e1011342-e1011342

2023

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Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5'-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase

Antimicrobial agents and chemotherapy, 2018-02, Vol.62 (2)

2018

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Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection

SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model

Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2

Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies

Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses

Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model

Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Small-Molecule Antiviral β-d- N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

β-d- N 4 -Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome

Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections

Development of Hexadecyloxypropyl Tenofovir (CMX157) for Treatment of Infection Caused by Wild-Type and Nucleoside/Nucleotide-Resistant HIV

Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC)

4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication

Analysis of Ribonucleotide 5'-Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-Dependent RNA Polymerase by Using Nonradioactive Polymerase Assays

The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N4-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection

Analysis of the Potential for N 4 -Hydroxycytidine To Inhibit Mitochondrial Replication and Function

Analysis of the Potential for N4-Hydroxycytidine To Inhibit Mitochondrial Replication and Function

Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine

Lassa and Ebola virus inhibitors identified using minigenome and recombinant virus reporter systems

4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5'-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase

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