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Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19

Current opinion in virology, 2021-10, Vol.50, p.17-22

2021

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Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2

Antimicrobial agents and chemotherapy, 2021-05, Vol.65 (5)

2021

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4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication

Science (American Association for the Advancement of Science), 2022-01, Vol.375 (6577), p.161-167

2022

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Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model

Translational research : the journal of laboratory and clinical medicine, 2020-04, Vol.218, p.16-28

2020

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SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

Nature communications, 2022-07, Vol.13 (1), p.4416-4416, Article 4416

2022

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Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

Antimicrobial agents and chemotherapy, 2018-08, Vol.62 (8)

2018

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Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2

Trials, 2021-08, Vol.22 (1), p.561-561, Article 561

2021

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Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Journal of virology, 2019-12, Vol.93 (24)

2019

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Small-Molecule Antiviral β-d- N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Journal of virology, 2019-12, Vol.93 (24)

2019

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β-d- N 4 -Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome

Journal of virology, 2018-02, Vol.92 (3)

2018

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The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection

Antiviral research, 2019-11, Vol.171, p.104597-104597, Article 104597

2019

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First Pharmacokinetic and Safety Study in Humans of the Novel Lipid Antiviral Conjugate CMX001, a Broad-Spectrum Oral Drug Active against Double-Stranded DNA Viruses

Antimicrobial Agents and Chemotherapy, 2012-05, Vol.56 (5), p.2726-2734

2012

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Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC)

Accounts of chemical research, 2016-10, Vol.49 (10), p.2091-2098

2016

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Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

Nature communications, 2023-08, Vol.14 (1), p.4731-4731, Article 4731

2023

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Analysis of Ribonucleotide 5'-Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-Dependent RNA Polymerase by Using Nonradioactive Polymerase Assays

Antimicrobial agents and chemotherapy, 2017-03, Vol.61 (3)

2017

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The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N4-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection

Antiviral research, 2023-01, Vol.209, p.105453-105453, Article 105453

2023

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Analysis of the Potential for N 4 -Hydroxycytidine To Inhibit Mitochondrial Replication and Function

Antimicrobial agents and chemotherapy, 2020-01, Vol.64 (2)

2020

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4'-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo

mBio, 2024-06, Vol.15 (6), p.e0042024

2024

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Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (20), p.7293-7297

2008

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Analysis of the Potential for N4-Hydroxycytidine To Inhibit Mitochondrial Replication and Function

Antimicrobial agents and chemotherapy, 2020-01, Vol.64 (2)

2020

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Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine

Journal of virology, 2024-04, Vol.98 (4), p.e0013224

2024

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Lassa and Ebola virus inhibitors identified using minigenome and recombinant virus reporter systems

Antiviral research, 2016-12, Vol.136 (C), p.9-18

2016

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Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies

The Journal of infectious diseases, 2010-11, Vol.202 (10), p.1492-1499

2010

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Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses

Antimicrobial Agents and Chemotherapy, 2007-11, Vol.51 (11), p.4118-4124

2007

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Development of CMX001 for the Treatment of Poxvirus Infections

Viruses, 2010-12, Vol.2 (12), p.2740-2762

2010

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Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19

Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2

4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication

Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model

SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2

Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Small-Molecule Antiviral β-d- N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

β-d- N 4 -Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome

The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection

First Pharmacokinetic and Safety Study in Humans of the Novel Lipid Antiviral Conjugate CMX001, a Broad-Spectrum Oral Drug Active against Double-Stranded DNA Viruses

Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC)

Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

Analysis of Ribonucleotide 5'-Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-Dependent RNA Polymerase by Using Nonradioactive Polymerase Assays

The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N4-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection

Analysis of the Potential for N 4 -Hydroxycytidine To Inhibit Mitochondrial Replication and Function

4'-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo

Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model

Analysis of the Potential for N4-Hydroxycytidine To Inhibit Mitochondrial Replication and Function

Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine

Lassa and Ebola virus inhibitors identified using minigenome and recombinant virus reporter systems

Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies

Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses

Development of CMX001 for the Treatment of Poxvirus Infections

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