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Validation of Early Human Dose Prediction: A Key Metric for Compound Progression in Drug Discovery

Molecular pharmaceutics, 2016-02, Vol.13 (2), p.609-620

Page, Ken M

2016

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In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

Chemical research in toxicology, 2012-08, Vol.25 (8), p.1616-1632

2012

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Time dependent analysis of assay comparability: a novel approach to understand intra- and inter-site variability over time

Journal of computer-aided molecular design, 2015-09, Vol.29 (9), p.795-807

2015

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Hydantoin based inhibitors of MMP13—Discovery of AZD6605

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4705-4712

2013

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Decontamination and reuse of personal protective masks and respirators in healthcare: Human-centered investigation and implementation considerations

Human Factors in Healthcare (Online), 2021-12, Vol.1, p.100003-100003, Article 100003

2021

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The effect of river regulation on floodplain wetland inundation, Murrumbidgee River, Australia

Marine and freshwater research, 2006-01, Vol.57 (2), p.133

2006

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Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo)

American journal of physiology: endocrinology and metabolism, 2006-09, Vol.291 (3), p.E596-E603

2006

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Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor

Bioorganic & medicinal chemistry letters, 2003-09, Vol.13 (18), p.3097-3100

2003

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Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors

Journal of medicinal chemistry, 2012-10, Vol.55 (20), p.8827-8837

2012

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Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5563-5568

2012

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Aminoimidazolylmethyluracil Analogues as Potent Inhibitors of Thymidine Phosphorylase and Their Bioreductive Nitroimidazolyl Prodrugs

Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.392-402

2005

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reach-scale remote sensing technique to relate wetland inundation to river flow

River research and applications, 2009-09, Vol.25 (7), p.836-849

2009

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Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background

Molecular cancer therapeutics, 2012-04, Vol.11 (4), p.873-887

2012

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Discovery of 4‑{4-[(3R)‑3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}‑1H‑indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

Journal of medicinal chemistry, 2013-03, Vol.56 (5), p.2125-2138

2013

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Discovery of 4‑Amino‑N‑[(1S)‑1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases

Journal of medicinal chemistry, 2013-03, Vol.56 (5), p.2059-2073

2013

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Addressing personal protective equipment (PPE) decontamination: Methylene blue and light inactivates severe acute respiratory coronavirus virus 2 (SARS-CoV-2) on N95 respirators and medical masks with maintenance of integrity and fit

Infection control and hospital epidemiology, 2022-07, Vol.43 (7), p.876-885

2022

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Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

Chemico-biological interactions, 2011-06, Vol.192 (1), p.65-71

2011

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A preliminary study on the current state of e-learning in lifelong learning

Page, Ken

2006

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Effects of Flow Regulation in Flow Regime on the Murrumbidgee River, South Eastern Australia: an assessment using a daily estimation hydrological model

Australian geographer, 2005-11, Vol.36 (3), p.301-314

2005

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Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors

Bioorganic & medicinal chemistry letters, 2017-07, Vol.27 (13), p.3030-3035

2017

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Gift Theory: A New Theoretical Construct and Its Application to Gay, Bisexual, and Transgender Men in Large-Group Retreats

Group (New York. 1977), 2009-09, Vol.33 (3), p.235-244

Page, Ken

2009

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Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold

Bioorganic & medicinal chemistry letters, 2015-07, Vol.25 (13), p.2679-2685

2015

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Multiple surface plasmon resonance quantification of dextromethorphan using a molecularly imprinted β-cyclodextrin polymer: A potential probe for drug–drug interactions

Sensors and actuators. B, Chemical, 2009-05, Vol.139 (1), p.22-29

2009

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Validation of Early Human Dose Prediction: A Key Metric for Compound Progression in Drug Discovery

In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

Time dependent analysis of assay comparability: a novel approach to understand intra- and inter-site variability over time

Hydantoin based inhibitors of MMP13—Discovery of AZD6605

Decontamination and reuse of personal protective masks and respirators in healthcare: Human-centered investigation and implementation considerations

(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis

The effect of river regulation on floodplain wetland inundation, Murrumbidgee River, Australia

Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo)

Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor

Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors

Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition

Aminoimidazolylmethyluracil Analogues as Potent Inhibitors of Thymidine Phosphorylase and Their Bioreductive Nitroimidazolyl Prodrugs

reach-scale remote sensing technique to relate wetland inundation to river flow

Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background

Discovery of 4‑{4-[(3R)‑3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}‑1H‑indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

Discovery of 4‑Amino‑N‑[(1S)‑1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases

Addressing personal protective equipment (PPE) decontamination: Methylene blue and light inactivates severe acute respiratory coronavirus virus 2 (SARS-CoV-2) on N95 respirators and medical masks with maintenance of integrity and fit

Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

A preliminary study on the current state of e-learning in lifelong learning

Effects of Flow Regulation in Flow Regime on the Murrumbidgee River, South Eastern Australia: an assessment using a daily estimation hydrological model

Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers

Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors

Gift Theory: A New Theoretical Construct and Its Application to Gay, Bisexual, and Transgender Men in Large-Group Retreats

Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold

Multiple surface plasmon resonance quantification of dextromethorphan using a molecularly imprinted β-cyclodextrin polymer: A potential probe for drug–drug interactions

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