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Chapter 201 - G-Protein-Coupled Receptors, Signal Fidelity, and Cell Transformation

Handbook of Cell Signaling, 2009, p.1635-1648

Second Edition, 2009

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Critical Role of the Pleckstrin Homology and Cysteine-rich Domains in Vav Signaling and Transforming Activity

The Journal of biological chemistry, 2002-10, Vol.277 (42), p.39350-39359

2002

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Decoding kinase-adverse event associations for small molecule kinase inhibitors

Nature communications, 2022-07, Vol.13 (1), p.4349-4349, Article 4349

2022

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essential role for Rac1 in endothelial cell function and vascular development

The FASEB journal, 2008-06, Vol.22 (6), p.1829-1838

2008

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FDA Approval of Palbociclib in Combination with Fulvestrant for the Treatment of Hormone ReceptorPositive, HER2-Negative Metastatic Breast Cancer

Clinical cancer research, 2016-10, Vol.22 (20), p.4968-4972

2016

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FDA Approval: Ribociclib for the Treatment of Postmenopausal Women with Hormone Receptor-Positive, HER2-Negative Advanced or Metastatic Breast Cancer

Clinical cancer research, 2018-07, Vol.24 (13), p.2999-3004

2018

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FDA Approval Summary: Rucaparib for the Treatment of Patients with Deleterious BRCA Mutation-Associated Advanced Ovarian Cancer

Clinical cancer research, 2017-12, Vol.23 (23), p.7165-7170

2017

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FDA Approval: Uridine Triacetate for the Treatment of Patients Following Fluorouracil or Capecitabine Overdose or Exhibiting Early-Onset Severe Toxicities Following Administration of These Drugs

Clinical cancer research, 2016-09, Vol.22 (18), p.4545-4549

2016

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U.S. Food and Drug Administration Approval: Cabozantinib for the Treatment of Advanced Renal Cell Carcinoma

Clinical cancer research, 2017-01, Vol.23 (2), p.330-335

2017

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U.S. Food and Drug Administration Approval: Neratinib for the Extended Adjuvant Treatment of Early-Stage HER2-Positive Breast Cancer

Clinical cancer research, 2018-08, Vol.24 (15), p.3486-3491

2018

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Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6

FEBS letters, 2008-01, Vol.582 (2), p.255-261

2008

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Nonclinical Evaluations of Small-Molecule Oncology Drugs: Integration into Clinical Dose Optimization and Toxicity Management

Clinical cancer research, 2016-06, Vol.22 (11), p.2618-2622

2016

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PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation

The Journal of biological chemistry, 2013-04, Vol.288 (17), p.12232-12243

2013

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Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

Oncogene, 2004-12, Vol.23 (58), p.9369-9380

2004

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Semaphorin 3E Initiates Antiangiogenic Signaling through Plexin D1 by Regulating Arf6 and R-Ras

Molecular and Cellular Biology, 2010-06, Vol.30 (12), p.3086-3098

2010

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U.S. Food and Drug Administration Approval: Carfilzomib for the Treatment of Multiple Myeloma

Clinical cancer research, 2013-09, Vol.19 (17), p.4559-4563

2013

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Vav transformation requires activation of multiple GTPases and regulation of gene expression

Molecular cancer research, 2004-12, Vol.2 (12), p.702-711

2004

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Vav Transformation Requires Activation of Multiple GTPases and Regulation of Gene Expression11USPHS grant CA63071 (C.J. Der) and Susan G. Komen Breast Cancer Foundation fellowship (A.E. Karnoub).Note: T.R. Palmby and K. Abe contributed equally to this work

Molecular cancer research, 2004-12, Vol.2 (12), p.702

2004

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Chapter 201 - G-Protein-Coupled Receptors, Signal Fidelity, and Cell Transformation

Critical Role of the Pleckstrin Homology and Cysteine-rich Domains in Vav Signaling and Transforming Activity

Decoding kinase-adverse event associations for small molecule kinase inhibitors

essential role for Rac1 in endothelial cell function and vascular development

FDA Approval of Palbociclib in Combination with Fulvestrant for the Treatment of Hormone ReceptorPositive, HER2-Negative Metastatic Breast Cancer

FDA Approval: Ribociclib for the Treatment of Postmenopausal Women with Hormone Receptor-Positive, HER2-Negative Advanced or Metastatic Breast Cancer

FDA Approval Summary: Niraparib for the Maintenance Treatment of Patients with Recurrent Ovarian Cancer in Response to Platinum-Based Chemotherapy

FDA Approval Summary: Rucaparib for the Treatment of Patients with Deleterious BRCA Mutation-Associated Advanced Ovarian Cancer

FDA Approval: Uridine Triacetate for the Treatment of Patients Following Fluorouracil or Capecitabine Overdose or Exhibiting Early-Onset Severe Toxicities Following Administration of These Drugs

U.S. Food and Drug Administration Approval: Cabozantinib for the Treatment of Advanced Renal Cell Carcinoma

U.S. Food and Drug Administration Approval: Neratinib for the Extended Adjuvant Treatment of Early-Stage HER2-Positive Breast Cancer

Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6

Nonclinical Evaluations of Small-Molecule Oncology Drugs: Integration into Clinical Dose Optimization and Toxicity Management

PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation

Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

Semaphorin 3E Initiates Antiangiogenic Signaling through Plexin D1 by Regulating Arf6 and R-Ras

U.S. Food and Drug Administration Approval: Carfilzomib for the Treatment of Multiple Myeloma

Vav transformation requires activation of multiple GTPases and regulation of gene expression

Vav Transformation Requires Activation of Multiple GTPases and Regulation of Gene Expression11USPHS grant CA63071 (C.J. Der) and Susan G. Komen Breast Cancer Foundation fellowship (A.E. Karnoub).Note: T.R. Palmby and K. Abe contributed equally to this work

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