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Natural products as modulators of eukaryotic protein secretion

Natural product reports, 2020-05, Vol.37 (5), p.717-736

2020

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Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel

Cell chemical biology, 2016-05, Vol.23 (5), p.561-566

2016

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The subset of peroxisomal tail-anchored proteins do not reach peroxisomes via ER, instead mitochondria can be involved

PloS one, 2023-12, Vol.18 (12), p.e0295047-e0295047

2023

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TSignal: a transformer model for signal peptide prediction

Bioinformatics (Oxford, England), 2023-06, Vol.39 (Supplement_1), p.i347-i356

2023

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Mycolactone subverts immunity by selectively blocking the Sec61 translocon

The Journal of experimental medicine, 2016-12, Vol.213 (13), p.2885-2896

2016

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Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

Journal of the American Chemical Society, 2019-05, Vol.141 (21), p.8450-8461

2019

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Electrophilic Fragment-Based Design of Reversible Covalent Kinase Inhibitors

Journal of the American Chemical Society, 2013-04, Vol.135 (14), p.5298-5301

2013

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Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature

Molecular & cellular proteomics, 2018-09, Vol.17 (9), p.1750-1765

2018

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Snapshots of actin and tubulin folding inside the TRiC chaperonin

Nature structural & molecular biology, 2022-05, Vol.29 (5), p.420-429

2022

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Functional reconstitution of human equilibrative nucleoside transporter-1 into styrene maleic acid co-polymer lipid particles

Biochimica et biophysica acta. Biomembranes, 2017-05, Vol.1859 (5), p.1059-1065

2017

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Missing-in-metastasis and IRSp53 deform PI(4,5)P₂-rich membranes by an inverse BAR domain-like mechanism

The Journal of cell biology, 2007-03, Vol.176 (7), p.953-964

2007

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Signal peptide mimicry primes Sec61 for client-selective inhibition

Nature chemical biology, 2023-09, Vol.19 (9), p.1054-1062

2023

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Prolonged and tunable residence time using reversible covalent kinase inhibitors

Nature chemical biology, 2015-07, Vol.11 (7), p.525-531

2015

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Wherever I may roam: organellar protein targeting and evolvability

Current opinion in genetics & development, 2019-10, Vol.58-59, p.9-16

2019

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Rapamycin-inspired macrocycles with new target specificity

Nature chemistry, 2019-03, Vol.11 (3), p.254-263

2019

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Structure of the actin-depolymerizing factor homology domain in complex with actin

The Journal of cell biology, 2008-07, Vol.182 (1), p.51-59

2008

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Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A

Biochemical pharmacology, 2021-01, Vol.183, p.114317-114317, Article 114317

2021

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An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

eLife, 2014-02, Vol.3, p.e01483

2014

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Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins

ACS chemical biology, 2020-08, Vol.15 (8), p.2125-2136

2020

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ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons

Frontiers in cellular neuroscience, 2018-08, Vol.12, p.217-217

2018

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Kendomycin Cytotoxicity against Bacterial, Fungal, and Mammalian Cells Is Due to Cation Chelation

Journal of natural products (Washington, D.C.), 2020-04, Vol.83 (4), p.965-971

2020

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Carbonic anhydrase seven bundles filamentous actin and regulates dendritic spine morphology and density

EMBO reports, 2021-04, Vol.22 (4), p.e50145-n/a

2021

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Protein translocation and retro-translocation across the endoplasmic reticulum are crucial to inflammatory effector CD4+ T cell function

Cytokine (Philadelphia, Pa.), 2020-05, Vol.129, p.154944-154944, Article 154944

2020

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Regulation of cytoskeletal dynamics by actin-monomer-binding proteins

Trends in cell biology, 2004-07, Vol.14 (7), p.386-394

2004

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Structural basis and evolutionary origin of actin filament capping by twinfilin

Proceedings of the National Academy of Sciences - PNAS, 2007-02, Vol.104 (9), p.3113-3118

2007

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Natural products as modulators of eukaryotic protein secretion

Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel

The subset of peroxisomal tail-anchored proteins do not reach peroxisomes via ER, instead mitochondria can be involved

TSignal: a transformer model for signal peptide prediction

Mycolactone subverts immunity by selectively blocking the Sec61 translocon

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

Electrophilic Fragment-Based Design of Reversible Covalent Kinase Inhibitors

Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature

Snapshots of actin and tubulin folding inside the TRiC chaperonin

Functional reconstitution of human equilibrative nucleoside transporter-1 into styrene maleic acid co-polymer lipid particles

Missing-in-metastasis and IRSp53 deform PI(4,5)P₂-rich membranes by an inverse BAR domain-like mechanism

Signal peptide mimicry primes Sec61 for client-selective inhibition

Prolonged and tunable residence time using reversible covalent kinase inhibitors

Wherever I may roam: organellar protein targeting and evolvability

Rapamycin-inspired macrocycles with new target specificity

Structure of the actin-depolymerizing factor homology domain in complex with actin

Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins

ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons

Kendomycin Cytotoxicity against Bacterial, Fungal, and Mammalian Cells Is Due to Cation Chelation

Carbonic anhydrase seven bundles filamentous actin and regulates dendritic spine morphology and density

Protein translocation and retro-translocation across the endoplasmic reticulum are crucial to inflammatory effector CD4+ T cell function

Regulation of cytoskeletal dynamics by actin-monomer-binding proteins

Structural basis and evolutionary origin of actin filament capping by twinfilin

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