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Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy

Nature communications, 2023-04, Vol.14 (1), p.2367-16, Article 2367

2023

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Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease

Neurobiology of aging, 2013-10, Vol.34 (10), p.2352-2360

2013

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Targeting Protein-Protein Interactions in the Proteasome Super-Assemblies

Current topics in medicinal chemistry, 2015-07, Vol.15 (20), p.2056-2067

2015

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The central unit within the 19S regulatory particle of the proteasome

Nature structural & molecular biology, 2008-06, Vol.15 (6), p.573-580

2008

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Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination

Nature communications, 2023-10, Vol.14 (1), p.6569-6569, Article 6569

2023

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AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages

Cell reports (Cambridge), 2023-09, Vol.42 (9), p.113067-113067, Article 113067

2023

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A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing

Biomolecules (Basel, Switzerland), 2023-03, Vol.13 (3), p.480

2023

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Electronic Circular Dichroism Detects Conformational Changes Associated with Proteasome Gating Confirmed Using AFM Imaging

Biomolecules (Basel, Switzerland), 2023-04, Vol.13 (4), p.704

2023

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AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor

PloS one, 2016-03, Vol.11 (3), p.e0151902-e0151902

2016

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The Growth-Suppressive Function of the Polycomb Group Protein Polyhomeotic Is Mediated by Polymerization of Its Sterile Alpha Motif (SAM) Domain

The Journal of biological chemistry, 2012-03, Vol.287 (12), p.8702-8713

2012

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Small Molecule Modulation of Proteasome Assembly

Biochemistry (Easton), 2018-07, Vol.57 (28), p.4214-4224

2018

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Rapamycin allosterically inhibits the proteasome

Molecular pharmacology, 2013-07, Vol.84 (1), p.104-113

2013

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Harnessing proteasome dynamics and allostery in drug design

Antioxidants & redox signaling, 2014-12, Vol.21 (17), p.2286-2301

2014

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Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer

Cancer research (Chicago, Ill.), 2021-08, Vol.81 (15), p.4110-4123

2021

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A Tetrahedral Transition State at the Active Sites of the 20S Proteasome Is Coupled to Opening of the α-Ring Channel

Structure (London), 2009-08, Vol.17 (8), p.1137-1147

2009

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Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer

Cancer research (Chicago, Ill.), 2020-04, Vol.80 (7), p.1551-1563

2020

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A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition

Biochimica et biophysica acta. Molecular basis of disease, 2014-11, Vol.1842 (11), p.2060-2072

2014

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Nanoenzymology of the 20S Proteasome: Proteasomal Actions Are Controlled by the Allosteric Transition

Biochemistry (Easton), 2002-06, Vol.41 (22), p.7047-7053

2002

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New Peptide-Based Pharmacophore Activates 20S Proteasome

Molecules (Basel, Switzerland), 2020-03, Vol.25 (6), p.1439

2020

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PAI-1 uncouples integrin-β1 from restrain by membrane-bound β-catenin to promote collagen fibril remodeling in obesity-related neoplasms

Cell reports (Cambridge), 2024-08, Vol.43 (8), p.114527, Article 114527

2024

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Ex vivo drug testing of patient-derived lung organoids to predict treatment responses for personalized medicine

Lung cancer (Amsterdam, Netherlands), 2024-04, Vol.190, p.107533, Article 107533

2024

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The proteasome in health and disease

Current pharmaceutical design, 2013, Vol.19 (6), p.1010-1028

2013

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Targeting Protein-Protein Interactions in the Ubiquitin-Proteasome Pathway

Advances in protein chemistry and structural biology, 2018, Vol.110, p.123-165

2018

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AFM of biological complexes: What can we learn?

Current opinion in colloid & interface science, 2008-10, Vol.13 (5), p.351-367

2008

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Pipecolic esters as minimized templates for proteasome inhibition

Organic & biomolecular chemistry, 2019-03, Vol.17 (10), p.2734-2746

2019

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Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy

Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease

Targeting Protein-Protein Interactions in the Proteasome Super-Assemblies

The central unit within the 19S regulatory particle of the proteasome

Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination

AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages

A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing

Electronic Circular Dichroism Detects Conformational Changes Associated with Proteasome Gating Confirmed Using AFM Imaging

AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor

The Growth-Suppressive Function of the Polycomb Group Protein Polyhomeotic Is Mediated by Polymerization of Its Sterile Alpha Motif (SAM) Domain

Small Molecule Modulation of Proteasome Assembly

Rapamycin allosterically inhibits the proteasome

Harnessing proteasome dynamics and allostery in drug design

Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer

A Tetrahedral Transition State at the Active Sites of the 20S Proteasome Is Coupled to Opening of the α-Ring Channel

Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer

A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition

Nanoenzymology of the 20S Proteasome: Proteasomal Actions Are Controlled by the Allosteric Transition

New Peptide-Based Pharmacophore Activates 20S Proteasome

PAI-1 uncouples integrin-β1 from restrain by membrane-bound β-catenin to promote collagen fibril remodeling in obesity-related neoplasms

Ex vivo drug testing of patient-derived lung organoids to predict treatment responses for personalized medicine

The proteasome in health and disease

Targeting Protein-Protein Interactions in the Ubiquitin-Proteasome Pathway

AFM of biological complexes: What can we learn?

Pipecolic esters as minimized templates for proteasome inhibition

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