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Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines

Journal of medicinal chemistry, 1993-11, Vol.36 (24), p.3784-3794

1993

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Penicillin derived C2-symmetric dimers as novel inhibitors of HIV-1 proteinase

Journal of medicinal chemistry, 1992-08, Vol.35 (16), p.3080-3081

1992

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A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: synthesis, mode of interaction, and structure-activity relationships

Journal of medicinal chemistry, 1993-10, Vol.36 (21), p.3120-3128

1993

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Synthesis and structure-activity relationships of a series of penicillin-derived HIV proteinase inhibitors containing a stereochemically unique peptide isostere

Journal of medicinal chemistry, 1993-10, Vol.36 (21), p.3129-3136

1993

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Benzophenone Derivatives: A Novel Series of Potent and Selective Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Journal of medicinal chemistry, 1995-05, Vol.38 (10), p.1657-1665

1995

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The expression and purification of human rhinovirus protease 3C

European journal of biochemistry, 1989-07, Vol.182 (3), p.547-555

1989

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Preparation of nucleotide mimics with potent inhibitory activity against HIV reverse transcriptase

Journal of the Chemical Society, Perkin Transactions 1, 1991 (12), p.3378

1991

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DNA chain termination activity and inhibition of human immunodeficiency virus reverse transcriptase by carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine triphosphate

The Journal of biological chemistry, 1992-02, Vol.267 (6), p.4177-4182

1992

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Hydrolysis of a Series of Synthetic Peptide Substrates by the Human Rhinovirus 14 3C Proteinase, Cloned and Expressed in Escherichia coli

Journal of general virology, 1989-11, Vol.70 (11), p.2931-2942

1989

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A consensus sequence for substrate hydrolysis by rhino virus 3C proteinase

FEBS letters, 1989-11, Vol.258 (1), p.75-78

1989

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Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus

Journal of antimicrobial chemotherapy, 1983-08, Vol.12 (2), p.119-126

1983

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Novel dimeric penicillin derived inhibitors of HIV-1 proteinase: interaction with the catalytic aspartates

Bioorganic & medicinal chemistry letters, 1993-04, Vol.3 (4), p.503-508

1993

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Synthesis and Structure-Activity Relationships of a Series of Penicillin-Derived HIV Proteinase Inhibitors: Heterocyclic Ring Systems Containing P1' and P2' Substituents

Journal of medicinal chemistry, 1994-10, Vol.37 (22), p.3707-3716

1994

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Discovery and Analysis of a Series of C2-Symmetric HIV-1 Proteinase Inhibitors Derived from Penicillin

Analytical biochemistry, 1994-01, Vol.216 (1), p.89-96

1994

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STUDIES ON THE RHINOVIRUS 3C PROTEASE

ORR, DAVID C

1988

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Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia

Cell reports (Cambridge), 2019-07, Vol.28 (2), p.526-540.e6

2019

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Social network architecture of human immune cells unveiled by quantitative proteomics

Nature immunology, 2017-05, Vol.18 (5), p.583-593

2017

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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

PloS one, 2018-11, Vol.13 (11), p.e0206279-e0206279

2018

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The Cognitive and Behavioral Phenotype of the 16p11.2 Deletion in a Clinically Ascertained Population

Biological psychiatry (1969), 2015-05, Vol.77 (9), p.785-793

2015

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Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

Journal of clinical oncology, 2015-08, Vol.33 (24), p.2646-2654

2015

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Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

Cell, 2015-01, Vol.160 (1-2), p.37-47

2015

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Towards advancing scientific knowledge of climate change impacts on short-duration rainfall extremes

Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences, 2021-04, Vol.379 (2195), p.20190542

2021

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Assessment of the relationship between quality of sleep and disease activity in inflammatory bowel disease patients

Inflammatory bowel diseases, 2013-10, Vol.19 (11), p.2440-2443

2013

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Early genome activation in Drosophila is extensive with an initial tendency for aborted transcripts and retained introns

Genome research, 2019-07, Vol.29 (7), p.1188-1197

2019

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Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines

Penicillin derived C2-symmetric dimers as novel inhibitors of HIV-1 proteinase

A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: synthesis, mode of interaction, and structure-activity relationships

Synthesis and structure-activity relationships of a series of penicillin-derived HIV proteinase inhibitors containing a stereochemically unique peptide isostere

Benzophenone Derivatives: A Novel Series of Potent and Selective Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

The expression and purification of human rhinovirus protease 3C

Preparation of nucleotide mimics with potent inhibitory activity against HIV reverse transcriptase

DNA chain termination activity and inhibition of human immunodeficiency virus reverse transcriptase by carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine triphosphate

Hydrolysis of a Series of Synthetic Peptide Substrates by the Human Rhinovirus 14 3C Proteinase, Cloned and Expressed in Escherichia coli

A consensus sequence for substrate hydrolysis by rhino virus 3C proteinase

Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus

Novel dimeric penicillin derived inhibitors of HIV-1 proteinase: interaction with the catalytic aspartates

Synthesis and Structure-Activity Relationships of a Series of Penicillin-Derived HIV Proteinase Inhibitors: Heterocyclic Ring Systems Containing P1' and P2' Substituents

Discovery and Analysis of a Series of C2-Symmetric HIV-1 Proteinase Inhibitors Derived from Penicillin

STUDIES ON THE RHINOVIRUS 3C PROTEASE

Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia

Recessive mutations in SPTBN2 implicate β-III spectrin in both cognitive and motor development

Social network architecture of human immune cells unveiled by quantitative proteomics

Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

The Cognitive and Behavioral Phenotype of the 16p11.2 Deletion in a Clinically Ascertained Population

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

Towards advancing scientific knowledge of climate change impacts on short-duration rainfall extremes

Assessment of the relationship between quality of sleep and disease activity in inflammatory bowel disease patients

Early genome activation in Drosophila is extensive with an initial tendency for aborted transcripts and retained introns

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