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Recent advances toward a molecular mechanism of efflux pump inhibition

Frontiers in microbiology, 2015-05, Vol.6, p.421-421

2015

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Optimization of a novel series of pyranopyridine RND efflux pump inhibitors

Current opinion in microbiology, 2016-10, Vol.33, p.1-6

2016

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Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (13), p.3509-3514

2016

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Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

Antimicrobial Agents and Chemotherapy, 2014-02, Vol.58 (2), p.722-733

2014

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trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

Nature communications, 2021-03, Vol.12 (1), p.1799-12, Article 1799

2021

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Structure–activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors

Bioorganic & medicinal chemistry, 2015-05, Vol.23 (9), p.2024-2034

2015

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The hydrophobic trap—the Achilles heel of RND efflux pumps

Research in microbiology, 2018-09, Vol.169 (7-8), p.393-400

2018

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Towards Development of Small Molecule Lipid II Inhibitors as Novel Antibiotics

PloS one, 2016-10, Vol.11 (10), p.e0164515-e0164515

2016

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Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors

Antimicrobial agents and chemotherapy, 2014-10, Vol.58 (10), p.6224-6234

2014

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Aryl Rhodanines Specifically Inhibit Staphylococcal and Enterococcal Biofilm Formation

Antimicrobial Agents and Chemotherapy, 2009-10, Vol.53 (10), p.4357-4367

2009

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Adjunctive therapy for multidrug-resistant bacterial infections: Type III secretion system and efflux inhibitors

Drug discovery today, 2021-09, Vol.26 (9), p.2173-2181

2021

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Luciferase-Based High-Throughput Screen with Aspergillus fumigatus to Identify Antifungal Small Molecules

Methods in molecular biology (Clifton, N.J.), 2023, Vol.2658, p.17

2023

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In Vitro Potency and In Vivo Efficacy of a Novel Bis-Indole Antimicrobial Compound in Reducing Catheter Colonization

Antimicrobial Agents and Chemotherapy, 2012-04, Vol.56 (4), p.2201-2204

2012

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Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

mBio, 2017-07, Vol.8 (4)

2017

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Exposure of Escherichia coli to antibiotic-efflux pump inhibitor combinations in a pharmacokinetic model: impact on bacterial clearance and drug resistance

Journal of antimicrobial chemotherapy, 2023-12, Vol.78 (12), p.2869-2877

2023

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Convallatoxin-Induced Reduction of Methionine Import Effectively Inhibits Human Cytomegalovirus Infection and Replication

Journal of virology, 2016-12, Vol.90 (23), p.10715-10727

2016

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Cell-Based Assay to Determine Type 3 Secretion System Translocon Assembly in Pseudomonas aeruginosa Using Split Luciferase

ACS infectious diseases, 2023-12, Vol.9 (12), p.2652-2664

2023

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Investigating N-arylpyrimidinamine (NAPA) compounds as early-stage inhibitors against human cytomegalovirus

Antiviral research, 2023-01, Vol.209, p.105474-105474, Article 105474

2023

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Static Biofilm Cultures of Gram‐Positive Pathogens Grown in a Microtiter Format Used for Anti‐Biofilm Drug Discovery

Current Protocols in Pharmacology, 2010-09, Vol.50 (1), p.13A.8.1-13A.8.23

2010

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Optimization of a small-molecule Lipid II binder

Bioorganic & medicinal chemistry letters, 2019-07, Vol.29 (14), p.1849-1853

2019

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DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics

Antimicrobial agents and chemotherapy, 2016-12, Vol.60 (12), p.7067-7076

2016

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New classes of antibiotics

Current opinion in pharmacology, 2012-10, Vol.12 (5), p.535-544

2012

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Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds

Bioorganic & medicinal chemistry, 2015-09, Vol.23 (17), p.5789-5798

2015

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Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: Synthesis and SAR of novel analogs of MBX 1066 and MBX 1090

Bioorganic & medicinal chemistry, 2013-12, Vol.21 (24), p.7790-7806

2013

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Recent advances toward a molecular mechanism of efflux pump inhibition

Optimization of a novel series of pyranopyridine RND efflux pump inhibitors

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

Structure–activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors

The hydrophobic trap—the Achilles heel of RND efflux pumps

Towards Development of Small Molecule Lipid II Inhibitors as Novel Antibiotics

Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors

Aryl Rhodanines Specifically Inhibit Staphylococcal and Enterococcal Biofilm Formation

Adjunctive therapy for multidrug-resistant bacterial infections: Type III secretion system and efflux inhibitors

Luciferase-Based High-Throughput Screen with Aspergillus fumigatus to Identify Antifungal Small Molecules

In Vitro Potency and In Vivo Efficacy of a Novel Bis-Indole Antimicrobial Compound in Reducing Catheter Colonization

Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

Exposure of Escherichia coli to antibiotic-efflux pump inhibitor combinations in a pharmacokinetic model: impact on bacterial clearance and drug resistance

Convallatoxin-Induced Reduction of Methionine Import Effectively Inhibits Human Cytomegalovirus Infection and Replication

Cell-Based Assay to Determine Type 3 Secretion System Translocon Assembly in Pseudomonas aeruginosa Using Split Luciferase

Investigating N-arylpyrimidinamine (NAPA) compounds as early-stage inhibitors against human cytomegalovirus

Unsaturated fatty acid perturbation combats emerging triazole antifungal resistance in the human fungal pathogen Aspergillus fumigatus

Static Biofilm Cultures of Gram‐Positive Pathogens Grown in a Microtiter Format Used for Anti‐Biofilm Drug Discovery

Optimization of a small-molecule Lipid II binder

DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics

New classes of antibiotics

Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: Synthesis and SAR of novel analogs of MBX 1066 and MBX 1090

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