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Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer

Molecular cell, 2013-03, Vol.49 (5), p.884-896

2013

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Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design

Science advances, 2020-10, Vol.6 (42)

2020

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PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis

Nature communications, 2021-06, Vol.12 (1), p.3444-13, Article 3444

2021

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Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI

Nature communications, 2017-08, Vol.8 (1), p.211-14, Article 211

2017

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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity

Nature communications, 2021-11, Vol.12 (1), p.6896-6896, Article 6896

2021

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A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Cell reports (Cambridge), 2021-09, Vol.36 (13), p.109754-109754, Article 109754

2021

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Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development

Frontiers in chemistry, 2022-02, Vol.9, p.819165-819165

2022

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Structural basis for adenylation and thioester bond formation in the ubiquitin E1

Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (31), p.15475-15484

2019

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Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification

Nature communications, 2021-04, Vol.12 (1), p.2370-2370, Article 2370

2021

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Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

Nature communications, 2018-12, Vol.9 (1), p.5145-12, Article 5145

2018

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Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34

Nature communications, 2019-07, Vol.10 (1), p.3296-15, Article 3296

2019

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Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL

Nature communications, 2024-03, Vol.15 (1), p.2743-17, Article 2743

2024

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Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase

Scientific reports, 2023-06, Vol.13 (1), p.9161-9161, Article 9161

2023

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Domain alternation and active site remodeling are conserved structural features of ubiquitin E1

The Journal of biological chemistry, 2017-07, Vol.292 (29), p.12089-12099

2017

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Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer

Nature communications, 2023-08, Vol.14 (1), p.4786-4786, Article 4786

2023

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Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

Scientific reports, 2022-08, Vol.12 (1), p.14230-14230, Article 14230

2022

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Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members

Molecular and Cellular Biology, 2007-05, Vol.27 (9), p.3417-3428

2007

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Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6

Nature communications, 2022-08, Vol.13 (1), p.4880-4880, Article 4880

2022

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Crystal Structures of an E1‐E2‐ubiquitin Thioester Mimetic Reveal Molecular Mechanisms of Transthioesterification

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

Olsen, Shaun K.

2022

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Crystal Structure of the Nephila clavipes Major Ampullate Spidroin 1A N-terminal Domain Reveals Plasticity at the Dimer Interface

The Journal of biological chemistry, 2016-09, Vol.291 (36), p.19006-19017

2016

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Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism

The Journal of clinical investigation, 2007-02, Vol.117 (2), p.457-463

2007

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A protein canyon in the FGF–FGF receptor dimer selects from an à la carte menu of heparan sulfate motifs

Current opinion in structural biology, 2005-10, Vol.15 (5), p.506-516

2005

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Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain

Genes & development, 2006-01, Vol.20 (2), p.185-198

2006

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Fibroblast Growth Factor (FGF) Homologous Factors Share Structural but Not Functional Homology with FGFs

Journal of crystal growth, 2003-09, Vol.278 (36), p.34226-34236

2003

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Insights into the Molecular Basis for Fibroblast Growth Factor Receptor Autoinhibition and Ligand-Binding Promiscuity

Proceedings of the National Academy of Sciences - PNAS, 2004-01, Vol.101 (4), p.935-940

2004

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Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design

PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis

Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity

A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development

Structural basis for adenylation and thioester bond formation in the ubiquitin E1

Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification

Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34

Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase

Domain alternation and active site remodeling are conserved structural features of ubiquitin E1

Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer

Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members

Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6

Crystal Structures of an E1‐E2‐ubiquitin Thioester Mimetic Reveal Molecular Mechanisms of Transthioesterification

Crystal Structure of the Nephila clavipes Major Ampullate Spidroin 1A N-terminal Domain Reveals Plasticity at the Dimer Interface

Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism

A protein canyon in the FGF–FGF receptor dimer selects from an à la carte menu of heparan sulfate motifs

Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain

Fibroblast Growth Factor (FGF) Homologous Factors Share Structural but Not Functional Homology with FGFs

Insights into the Molecular Basis for Fibroblast Growth Factor Receptor Autoinhibition and Ligand-Binding Promiscuity

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