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Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways

Journal of proteomics, 2019-01, Vol.190, p.12-20

2019

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Characterization of the Conus bullatus genome and its venom-duct transcriptome

BMC genomics, 2011-01, Vol.12 (1), p.60-60, Article 60

2011

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Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct

BMC genomics, 2012-06, Vol.13 (1), p.284-284, Article 284

2012

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Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism

Journal of medicinal chemistry, 2021-07, Vol.64 (13), p.9271-9278

2021

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Conus venoms - a rich source of peptide-based therapeutics

Current pharmaceutical design, 2008-08, Vol.14 (24), p.2462

2008

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Conus Venoms: A Rich Source of Novel Ion Channel-Targeted Peptides

Physiological reviews, 2004-01, Vol.84 (1), p.41-68

2004

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Specialized insulin is used for chemical warfare by fish-hunting cone snails

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (6), p.1743-1748

2015

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From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function

Journal of molecular biology, 2015-01, Vol.427 (1), p.158-175

2015

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Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel NaV1.7

Frontiers in pharmacology, 2023-03, Vol.14, p.1156855-1156855

2023

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Venom Insulins of Cone Snails Diversify Rapidly and Track Prey Taxa

Molecular biology and evolution, 2016-11, Vol.33 (11), p.2924-2934

2016

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Prey-Capture Strategies of Fish-Hunting Cone Snails: Behavior, Neurobiology and Evolution

Brain, behavior and evolution, 2015-09, Vol.86 (1), p.58-74

2015

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trans -Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel

Molecular pharmacology, 2019-04, Vol.95 (4), p.433-441

2019

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Molecular mechanism for analgesia involving specific antagonism of alpha 9 alpha 10 nicotinic acetylcholine receptors

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (47), p.17880-17884

2006

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Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (16), p.5087-5092

2015

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Folding of conotoxins: formation of the native disulfide bridges during chemical synthesis and biosynthesis of Conus peptides

Antioxidants & redox signaling, 2008-01, Vol.10 (1), p.141

2008

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Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins

International journal of molecular sciences, 2018-10, Vol.19 (11), p.3418

2018

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Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (12), p.3227-3232

2016

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Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass

Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (6), p.2319-2324

2014

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Conotoxin contulakin-G engages a neurotensin receptor 2 /R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception

Pain (Amsterdam), 2022-09, Vol.163 (9), p.1751-1762

2022

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Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

eLife, 2019-02, Vol.8

2019

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Cannabinoid receptor agonists from Conus venoms alleviate pain-related behavior in rats

Pharmacology, biochemistry and behavior, 2021-06, Vol.205, p.173182-173182, Article 173182

2021

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TRPA1 expression levels and excitability brake by KV channels influence cold sensitivity of TRPA1-expressing neurons

Neuroscience, 2017-06, Vol.353, p.76-86

2017

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Molecular characterization of frog vocal neurons using constellation pharmacology

Journal of neurophysiology, 2020-06, Vol.123 (6), p.2297-2310, Article jn.00105.2020

2020

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Constellation Pharmacology: A New Paradigm for Drug Discovery

Annual review of pharmacology and toxicology, 2015-01, Vol.55 (1), p.573-589

2015

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Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism

The FASEB journal, 2024-01, Vol.38 (1), p.e23374-n/a

2024

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Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways

Characterization of the Conus bullatus genome and its venom-duct transcriptome

Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct

Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism

Conus venoms - a rich source of peptide-based therapeutics

Conus Venoms: A Rich Source of Novel Ion Channel-Targeted Peptides

Specialized insulin is used for chemical warfare by fish-hunting cone snails

From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function

Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel NaV1.7

Venom Insulins of Cone Snails Diversify Rapidly and Track Prey Taxa

Prey-Capture Strategies of Fish-Hunting Cone Snails: Behavior, Neurobiology and Evolution

trans -Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel

Molecular mechanism for analgesia involving specific antagonism of alpha 9 alpha 10 nicotinic acetylcholine receptors

Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus

Folding of conotoxins: formation of the native disulfide bridges during chemical synthesis and biosynthesis of Conus peptides

Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins

Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides

Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass

Conotoxin contulakin-G engages a neurotensin receptor 2 /R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

Cannabinoid receptor agonists from Conus venoms alleviate pain-related behavior in rats

TRPA1 expression levels and excitability brake by KV channels influence cold sensitivity of TRPA1-expressing neurons

Molecular characterization of frog vocal neurons using constellation pharmacology

Constellation Pharmacology: A New Paradigm for Drug Discovery

Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism

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