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Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter

Oncogene, 2007-02, Vol.26 (5), p.633-640

2007

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The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells

Leukemia, 2003-02, Vol.17 (2), p.451-457

2003

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Design and Synthesis of Potent Nonpeptidic Farnesyltransferase Inhibitors Based on a Terphenyl Scaffold

Journal of medicinal chemistry, 2002-01, Vol.45 (1), p.177-188

2002

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The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status

Cell death and differentiation, 2002-07, Vol.9 (7), p.702-709

2002

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In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus

The Journal of clinical investigation, 2003-08, Vol.112 (3), p.407-414

2003

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The Farnesyltransferase Inhibitor, FTI-2153, Blocks Bipolar Spindle Formation and Chromosome Alignment and Causes Prometaphase Accumulation during Mitosis of Human Lung Cancer Cells

The Journal of biological chemistry, 2001-05, Vol.276 (19), p.16161-16167

2001

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A Class of Sterol 14-Demethylase Inhibitors as Anti-Trypanosoma cruzi Agents

Proceedings of the National Academy of Sciences - PNAS, 2003-12, Vol.100 (25), p.15149-15153

2003

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Synthesis of Quinoxaline Derivatives Bearing the Styryl and Phenylethynyl Groups and Application to a Fluorescence Derivatization Reagent

Heterocycles, 2000-02, Vol.52 (2), p.911

2000

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Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I : Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine

Cancer research (Chicago, Ill.), 1999-10, Vol.59 (19), p.4919-4926

1999

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Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice

Cancer research (Chicago, Ill.), 2003-12, Vol.63 (24), p.8922-8929

2003

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Inhibitors of protein farnesyltransferase as novel anticancer agents

Current topics in medicinal chemistry, 2002-03, Vol.2 (3), p.303-323

2002

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Design and Synthesis of Peptidomimetic Protein Farnesyltransferase Inhibitors as Anti-Trypanosoma brucei Agents

Journal of medicinal chemistry, 2004-01, Vol.47 (2), p.432-445

2004

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In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability

Bioorganic & medicinal chemistry, 2004-12, Vol.12 (24), p.6517-6526

2004

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Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity

Bioorganic & medicinal chemistry letters, 2001-03, Vol.11 (6), p.761-764

2001

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4.10 - Self-Assembled Receptors for Protein Surface Recognition

Comprehensive Supramolecular Chemistry II, 2017, p.351-369

Ohkanda, J.

Second Edition, 2017

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Potent, Highly Selective, and Non-Thiol Inhibitors of Protein Geranylgeranyltransferase-I

Journal of medicinal chemistry, 1999-04, Vol.42 (8), p.1333-1340

1999

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Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase

Organic & biomolecular chemistry, 2006-02, Vol.4 (3), p.482

2006

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CAAX peptidomimetics: their farnesyltransferase inhibition activity and antitumor effect

Seikagaku. The Journal of Japanese Biochemical Society, 2002-01, Vol.74 (1), p.46

Ohkanda, Junko

2002

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N-Hydroxypyrazinone-bearing homotrioxacalix[3]arene: its cooperative molecular recognition by metal complexation

Chemical communications (Cambridge, England), 1998 (3), p.375-376

1998

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Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter

Oncogene, 2007-01, Vol.26 (5), p.633-640

2007

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Inhibition of farnesyltransferase increases TGFβ type II receptor expression and enhances the responsiveness of human cancer cells to TGFβ

Oncogene, 2000-11, Vol.19 (48), p.5525-5533

2000

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Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Carcinogenesis (New York), 2000-01, Vol.21 (1), p.113-116

2000

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Development of a Tripeptide Mimetic Strategy for the Inhibition of Protein Farnesyltransferase

Tetrahedron, 2000-12, Vol.56 (50), p.9833-9841

2000

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The Influence of the Chirality of Synthetic Iron Chelators Bearing N -Hydroxy-2(1 H )-pyrazinones and Amino Acid Residues upon Iron Removal from Human Transferrin

Chemistry letters, 1996-06, Vol.25 (6), p.423-424

1996

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Novel Iron Sequestering Agents: Synthesis and Iron-Chelating Properties of Hexadentate Ligands Composed of 1-Hydroxy-2(1H)-pyrimidinone, ω-Amino Carboxylic Acid, and Tris(2-aminoethyl)amine

Journal of organic chemistry, 1997-05, Vol.62 (11), p.3618-3624

1997

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Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter

The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells

Design and Synthesis of Potent Nonpeptidic Farnesyltransferase Inhibitors Based on a Terphenyl Scaffold

The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status

In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus

The Farnesyltransferase Inhibitor, FTI-2153, Blocks Bipolar Spindle Formation and Chromosome Alignment and Causes Prometaphase Accumulation during Mitosis of Human Lung Cancer Cells

A Class of Sterol 14-Demethylase Inhibitors as Anti-Trypanosoma cruzi Agents

Synthesis of Quinoxaline Derivatives Bearing the Styryl and Phenylethynyl Groups and Application to a Fluorescence Derivatization Reagent

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I : Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine

Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice

Inhibitors of protein farnesyltransferase as novel anticancer agents

Design and Synthesis of Peptidomimetic Protein Farnesyltransferase Inhibitors as Anti-Trypanosoma brucei Agents

In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability

Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity

4.10 - Self-Assembled Receptors for Protein Surface Recognition

Potent, Highly Selective, and Non-Thiol Inhibitors of Protein Geranylgeranyltransferase-I

Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase

CAAX peptidomimetics: their farnesyltransferase inhibition activity and antitumor effect

N-Hydroxypyrazinone-bearing homotrioxacalix[3]arene: its cooperative molecular recognition by metal complexation

Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter

Inhibition of farnesyltransferase increases TGFβ type II receptor expression and enhances the responsiveness of human cancer cells to TGFβ

Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Development of a Tripeptide Mimetic Strategy for the Inhibition of Protein Farnesyltransferase

The Influence of the Chirality of Synthetic Iron Chelators Bearing N -Hydroxy-2(1 H )-pyrazinones and Amino Acid Residues upon Iron Removal from Human Transferrin

Novel Iron Sequestering Agents: Synthesis and Iron-Chelating Properties of Hexadentate Ligands Composed of 1-Hydroxy-2(1H)-pyrimidinone, ω-Amino Carboxylic Acid, and Tris(2-aminoethyl)amine

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