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General Synthesis of Conformationally Constrained Noncanonical Amino Acids with C(sp 3)‑Rich Benzene Bioisosteres

Journal of organic chemistry, 2024-04, Vol.89 (7), p.5010-5018

2024

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Desmethoxymajusculamide C, a Cyanobacterial Depsipeptide with Potent Cytotoxicity in Both Cyclic and Ring-Opened Forms

Journal of natural products (Washington, D.C.), 2009-06, Vol.72 (6), p.1011-1016

2009

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Rapid method development for chiral separation in drug discovery using multi-column parallel screening and circular dichroism signal pooling

Journal of Chromatography A, 2004-09, Vol.1049 (1), p.75-84

2004

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Somocystinamide A, a Novel Cytotoxic Disulfide Dimer from a Fijian Marine Cyanobacterial Mixed Assemblage

Organic letters, 2002-04, Vol.4 (7), p.1095-1098

2002

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Isolation of Four New Cyclic Depsipeptides, Antanapeptins A−D, and Dolastatin 16 from a Madagascan Collection of Lyngbya majuscula

Journal of natural products (Washington, D.C.), 2002-01, Vol.65 (1), p.21-24

2002

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Diverse Secondary Metabolites from a Puerto Rican Collection of Lyngbya majuscula

Journal of natural products (Washington, D.C.), 2003-02, Vol.66 (2), p.217-220

2003

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Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (12), p.3742-3745

2010

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Antillatoxin B, a Neurotoxic Lipopeptide from the Marine Cyanobacterium Lyngbya majuscula

Journal of natural products (Washington, D.C.), 2001-07, Vol.64 (7), p.983-985

2001

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Preparative separation and identification of derivatized β-methylphenylalanine enantiomers by chiral SFC, HPLC and NMR for development of new peptide ligand mimetics in drug discovery

Journal of pharmaceutical and biomedical analysis, 2006-03, Vol.40 (4), p.901-909

2006

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Somamides A and B, Two New Depsipeptide Analogues of Dolastatin 13 from a Fijian Cyanobacterial Assemblage of Lyngbya majuscula and Schizothrix Species

Journal of natural products (Washington, D.C.), 2001-06, Vol.64 (6), p.716-719

2001

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Wewakazole, a novel cyclic dodecapeptide from a Papua New Guinea Lyngbya majuscula

Organic letters, 2003-01, Vol.5 (1), p.3-6

2003

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Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1 H-indol-1-yl)-3-arylpropan-1-amines

Bioorganic & medicinal chemistry, 2006-12, Vol.14 (24), p.8455-8466

2006

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Structure, Synthesis, and Biological Properties of Kalkitoxin, a Novel Neurotoxin from the Marine Cyanobacterium Lyngbya majuscula

Journal of the American Chemical Society, 2000-12, Vol.122 (48), p.12041-12042

2000

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Sub-2 μm HPLC coupled with sub-ppm mass accuracy for analysis of pharmaceutical compound libraries

Journal of separation science, 2008-12, Vol.31 (21), p.3698-3703

2008

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Evaluation of non-conventional polar modifiers on immobilized chiral stationary phases for improved resolution of enantiomers by supercritical fluid chromatography

Journal of Chromatography A, 2014-02, Vol.1328, p.98-103

2014

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Abstract 297: Innovation in delivering synthetically challenging bicyclic arginase inhibitors to enhance immunotherapy

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.297-297

2021

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Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter

ACS medicinal chemistry letters, 2010-06, Vol.1 (3), p.91-95

2010

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Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula

Chemistry & biology, 2004-06, Vol.11 (6), p.817-833

2004

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16801-16817

2022

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16801-16817

2022

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Development of a Platform To Enable Efficient Permeability Evaluation of Novel Organo-Peptide Macrocycles

ACS medicinal chemistry letters, 2019-06, Vol.10 (6), p.874-879

2019

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General Synthesis of Conformationally Constrained Noncanonical Amino Acids with C(sp 3)‑Rich Benzene Bioisosteres

Cross-Pharma Collaboration on the Development and Evaluation of a New Mid-Scale Preparative Supercritical Fluid Chromatography Instrument

Desmethoxymajusculamide C, a Cyanobacterial Depsipeptide with Potent Cytotoxicity in Both Cyclic and Ring-Opened Forms

Rapid method development for chiral separation in drug discovery using multi-column parallel screening and circular dichroism signal pooling

Somocystinamide A, a Novel Cytotoxic Disulfide Dimer from a Fijian Marine Cyanobacterial Mixed Assemblage

Isolation of Four New Cyclic Depsipeptides, Antanapeptins A−D, and Dolastatin 16 from a Madagascan Collection of Lyngbya majuscula

Diverse Secondary Metabolites from a Puerto Rican Collection of Lyngbya majuscula

Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery-Building chiral technology toolboxes

Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists

Antillatoxin B, a Neurotoxic Lipopeptide from the Marine Cyanobacterium Lyngbya majuscula

Preparative separation and identification of derivatized β-methylphenylalanine enantiomers by chiral SFC, HPLC and NMR for development of new peptide ligand mimetics in drug discovery

Somamides A and B, Two New Depsipeptide Analogues of Dolastatin 13 from a Fijian Cyanobacterial Assemblage of Lyngbya majuscula and Schizothrix Species

Wewakazole, a novel cyclic dodecapeptide from a Papua New Guinea Lyngbya majuscula

Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1 H-indol-1-yl)-3-arylpropan-1-amines

Structure, Synthesis, and Biological Properties of Kalkitoxin, a Novel Neurotoxin from the Marine Cyanobacterium Lyngbya majuscula

Sub-2 μm HPLC coupled with sub-ppm mass accuracy for analysis of pharmaceutical compound libraries

Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors

Evaluation of non-conventional polar modifiers on immobilized chiral stationary phases for improved resolution of enantiomers by supercritical fluid chromatography

Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson’s Disease

Abstract 297: Innovation in delivering synthetically challenging bicyclic arginase inhibitors to enhance immunotherapy

Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter

Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease

Development of a Platform To Enable Efficient Permeability Evaluation of Novel Organo-Peptide Macrocycles

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