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6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

Journal of medicinal chemistry, 2001-08, Vol.44 (17), p.2719-2734

2001

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4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors

Journal of medicinal chemistry, 2000-08, Vol.43 (17), p.3244-3256

2000

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Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design

Journal of the American Chemical Society, 2000-10, Vol.122 (40), p.9648-9654

2000

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Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase

Cancer research (Chicago, Ill.), 2004-06, Vol.64 (11), p.3958-3965

2004

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Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity

Journal of medicinal chemistry, 2005-02, Vol.48 (4), p.1107-1131

2005

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Cloning and Characterization of a Sixth Adenylyl Cyclase Isoform: Types V and VI Constitute a Subgroup Within the Mammalian Adenylyl Cyclase Family

Proceedings of the National Academy of Sciences - PNAS, 1992-09, Vol.89 (18), p.8774-8778

1992

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2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as Covalent-Binding, Irreversible Inhibitors of the Kinase Domain of Vascular Endothelial Growth Factor Receptor-2

Journal of medicinal chemistry, 2005-12, Vol.48 (24), p.7560-7581

2005

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Searching for Pharmacophores in Large Coordinate Data Bases and Its Use in Drug Design

Proceedings of the National Academy of Sciences - PNAS, 1989-10, Vol.86 (20), p.8165-8169

1989

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A Family of Ring System-Based Structural Fragments for Use in Structure−Activity Studies: Database Mining and Recursive Partitioning

Journal of chemical information and modeling, 2006-05, Vol.46 (3), p.1069-1077

2006

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A novel approach to combinatorial library design

Combinatorial chemistry & high throughput screening, 2002-03, Vol.5 (2), p.105

2002

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Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: Analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.2893-2897

2002

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A fresh look at pharmaceutical screening library design

Drug discovery today, 2003-08, Vol.8 (15), p.668-672

2003

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Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (6), p.1411-1416

2004

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Inhibition of Influenza A Virus Replication by Compounds Interfering with the Fusogenic Function of the Viral Hemagglutinin

Journal of Virology, 1999-01, Vol.73 (1), p.140-151

1999

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Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with In Vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785)

Biochemical pharmacology, 1999-04, Vol.57 (8), p.917-925

1999

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Database diversity assessment: new ideas, concepts, and tools

Journal of computer-aided molecular design, 1997-09, Vol.11 (5), p.447-452

1997

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Molecular Modeling of the Aldose Reductase-Inhibitor Complex Based on the X-ray Crystal Structure and Studies with Single-Site-Directed Mutants

Journal of medicinal chemistry, 2000-03, Vol.43 (6), p.1062-1070

2000

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The ensemble approach to distance geometry: application to the nicotinic pharmacophore

Journal of medicinal chemistry, 1986-06, Vol.29 (6), p.899-906

1986

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New method for rapid characterization of molecular shapes: applications in drug design

Journal of chemical information and computer sciences, 1993-01, Vol.33 (1), p.79-85

1993

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Molecular Modeling Of The Aldose Reductase‐Inhibitor Complex Based On The X‐Ray Crystal Structure And Studies With Single‐Site‐ Directed Mutants

Journal of the peripheral nervous system, 2000-06, Vol.5 (2), p.120-120

2000

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Studies on the serological relationships between avian pox, sheep pox, goat pox and vaccinia viruses

The Journal of hygiene, 1970-09, Vol.68 (3), p.349-358

1970

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Comparison of sodium alginate and oil adjuvants in Pasteurella multocida vaccines

Journal of bacteriology, 1968-12, Vol.96 (6), p.2180-2180

1968

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Calicheamicin γ1I and DNA: molecular recognition process responsible for site-specificity

Science (American Association for the Advancement of Science), 1989, Vol.244 (4905), p.697-699

1989

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Calicheamicin gamma sub(1) super(I) and DNA: Molecular recognition process responsible for site-specificity

Science (American Association for the Advancement of Science), 1989-01, Vol.244 (4905), p.697-699

1989

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6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors

Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design

Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase

Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity

Cloning and Characterization of a Sixth Adenylyl Cyclase Isoform: Types V and VI Constitute a Subgroup Within the Mammalian Adenylyl Cyclase Family

Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)

2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as Covalent-Binding, Irreversible Inhibitors of the Kinase Domain of Vascular Endothelial Growth Factor Receptor-2

Searching for Pharmacophores in Large Coordinate Data Bases and Its Use in Drug Design

A Family of Ring System-Based Structural Fragments for Use in Structure−Activity Studies: Database Mining and Recursive Partitioning

A novel approach to combinatorial library design

Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: Analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents

A fresh look at pharmaceutical screening library design

Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles

Inhibition of Influenza A Virus Replication by Compounds Interfering with the Fusogenic Function of the Viral Hemagglutinin

Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with In Vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785)

Database diversity assessment: new ideas, concepts, and tools

Molecular Modeling of the Aldose Reductase-Inhibitor Complex Based on the X-ray Crystal Structure and Studies with Single-Site-Directed Mutants

The ensemble approach to distance geometry: application to the nicotinic pharmacophore

New method for rapid characterization of molecular shapes: applications in drug design

Molecular Modeling Of The Aldose Reductase‐Inhibitor Complex Based On The X‐Ray Crystal Structure And Studies With Single‐Site‐ Directed Mutants

Studies on the serological relationships between avian pox, sheep pox, goat pox and vaccinia viruses

Comparison of sodium alginate and oil adjuvants in Pasteurella multocida vaccines

Calicheamicin γ1I and DNA: molecular recognition process responsible for site-specificity

Calicheamicin gamma sub(1) super(I) and DNA: Molecular recognition process responsible for site-specificity

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