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Regulators of Mitotic Arrest and Ceramide Metabolism Are Determinants of Sensitivity to Paclitaxel and Other Chemotherapeutic Drugs

Cancer cell, 2007-06, Vol.11 (6), p.498-512

2007

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PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling

Cell death & disease, 2018-02, Vol.9 (2), p.192-15, Article 192

2018

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Chromosomal instability determines taxane response

Proceedings of the National Academy of Sciences - PNAS, 2009-05, Vol.106 (21), p.8671-8676

2009

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The Extracellular Matrix Protein TGFBI Induces Microtubule Stabilization and Sensitizes Ovarian Cancers to Paclitaxel

Cancer cell, 2007-12, Vol.12 (6), p.514-527

2007

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Deciphering Seed Sequence Based Off-Target Effects in a Large-Scale RNAi Reporter Screen for E-Cadherin Expression

PloS one, 2015-09, Vol.10 (9), p.e0137640-e0137640

2015

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CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

The Journal of pathology, 2012-02, Vol.226 (3), p.482-494

2012

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Involvement of MINK, a Ste20 Family Kinase, in Ras Oncogene-Induced Growth Arrest in Human Ovarian Surface Epithelial Cells

Molecular cell, 2005-12, Vol.20 (5), p.673-685

2005

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The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component

Molecular biology of the cell, 2004-07, Vol.15 (7), p.3450-3463

2004

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Initiation of High Frequency Multi-Drug Resistance Following Kinase Targeting by siRNAs

Cell cycle (Georgetown, Tex.), 2007-08, Vol.6 (16), p.2001-2004

2007

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Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice

Cell, 2007-06, Vol.129 (5), p.957-968

2007

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Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2‑d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5

Journal of medicinal chemistry, 2019-01, Vol.62 (2), p.928-940

2019

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Abstract 3055: Genome-wide CRISPR/Cas9 screen for the identification of novel YAP1/TAZ modulators

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3055-3055

2019

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Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.15883-15911

2021

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Concordance of exon array and real-time PCR assessment of gene expression following cancer cell cytotoxic drug exposure

Cell cycle (Georgetown, Tex.), 2008-12, Vol.7 (24), p.3947-3948

2008

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Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling

Cell chemical biology, 2024-07, Vol.31 (7), p.1247-1263.e16

2024

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Muscarinic Cholinergic Receptors Activate Both Inhibitory and Stimulatory Growth Mechanisms in NIH3T3 Cells

The Journal of biological chemistry, 1999-07, Vol.274 (31), p.21701-21706

1999

Volltextzugriff (PDF)

Abstract 1722: Enhancement of anti-tumor T-cell immunity by means of an oral small molecule targeting the intracellular immune checkpoint MAP4K1

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1722-1722

2021

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Abstract A29: Genome-wide CRISPR/Cas9 screens for the identification of novel YAP1/TAZ modulators

Molecular cancer research, 2020-08, Vol.18 (8_Supplement), p.A29-A29

2020

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Pan-PI3K inhibition with copanlisib overcomes Treg- and M2-TAM-mediated immune suppression and promotes anti-tumor immune responses

Clinical and experimental medicine, 2023-12, Vol.23 (8), p.5445-5461

2023

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Abstract 4973: MYCN mediates cysteine addiction and sensitizes to ferroptosis in cancer cells

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4973-4973

2018

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Abstract 6089: Identification of novel YAP/TAZ pathway regulators in the triple-negative breast cancer cell line MDA-MB231 using single-cell CRISPR screening

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.6089-6089

2023

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Functional Genomics in Pharmaceutical Drug Discovery

Handbook of experimental pharmacology, 2016, Vol.232, p.25-41

2016

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All-trans-Retinoic Acid-mediated Growth Inhibition Involves Inhibition of Human Kinesin-related Protein HsEg5

The Journal of biological chemistry, 1999-07, Vol.274 (27), p.18925-18931

1999

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Identification of novel gene expression targets for the ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma

Cancer research (Chicago, Ill.), 2003-09, Vol.63 (17), p.5344-5351

2003

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Regulators of Mitotic Arrest and Ceramide Metabolism Are Determinants of Sensitivity to Paclitaxel and Other Chemotherapeutic Drugs

PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling

Chromosomal instability determines taxane response

The Extracellular Matrix Protein TGFBI Induces Microtubule Stabilization and Sensitizes Ovarian Cancers to Paclitaxel

Deciphering Seed Sequence Based Off-Target Effects in a Large-Scale RNAi Reporter Screen for E-Cadherin Expression

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

Involvement of MINK, a Ste20 Family Kinase, in Ras Oncogene-Induced Growth Arrest in Human Ovarian Surface Epithelial Cells

The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component

Initiation of High Frequency Multi-Drug Resistance Following Kinase Targeting by siRNAs

Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice

Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2‑d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5

Abstract 3055: Genome-wide CRISPR/Cas9 screen for the identification of novel YAP1/TAZ modulators

Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A

Concordance of exon array and real-time PCR assessment of gene expression following cancer cell cytotoxic drug exposure

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis

Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling

Muscarinic Cholinergic Receptors Activate Both Inhibitory and Stimulatory Growth Mechanisms in NIH3T3 Cells

Abstract 1722: Enhancement of anti-tumor T-cell immunity by means of an oral small molecule targeting the intracellular immune checkpoint MAP4K1

Abstract A29: Genome-wide CRISPR/Cas9 screens for the identification of novel YAP1/TAZ modulators

Pan-PI3K inhibition with copanlisib overcomes Treg- and M2-TAM-mediated immune suppression and promotes anti-tumor immune responses

Abstract 4973: MYCN mediates cysteine addiction and sensitizes to ferroptosis in cancer cells

Abstract 6089: Identification of novel YAP/TAZ pathway regulators in the triple-negative breast cancer cell line MDA-MB231 using single-cell CRISPR screening

Functional Genomics in Pharmaceutical Drug Discovery

All-trans-Retinoic Acid-mediated Growth Inhibition Involves Inhibition of Human Kinesin-related Protein HsEg5

Identification of novel gene expression targets for the ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma

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