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Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

Molecular cell, 2016-11, Vol.64 (4), p.704-719

2016

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Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

Nature communications, 2021-08, Vol.12 (1), p.4848-11, Article 4848

2021

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Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

Structure (London), 2015-12, Vol.23 (12), p.2319-2330

2015

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RecQ helicases in DNA repair and cancer targets

Essays in biochemistry, 2020-10, Vol.64 (5), p.819-830

2020

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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Molecular cell, 2019-02, Vol.73 (3), p.621-638.e17

2019

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Molecular Basis of the Activity of SinR Protein, the Master Regulator of Biofilm Formation in Bacillus subtilis

The Journal of biological chemistry, 2013-04, Vol.288 (15), p.10766-10778

2013

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Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Nucleic acids research, 2021-09, Vol.49 (16), p.9310-9326

2021

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A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family

Nucleic acids research, 2021-09, Vol.49 (16), p.9294-9309

2021

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Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity

Nucleic acids research, 2023-10, Vol.51 (18), p.9920-9937

2023

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Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

Nucleic acids research, 2015-05, Vol.43 (10), p.5221-5235

2015

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SNM1A is crucial for efficient repair of complex DNA breaks in human cells

Nature communications, 2024-06, Vol.15 (1), p.5392-17, Article 5392

2024

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Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development

Nucleic acids research, 2023-01, Vol.51 (1), p.475-487

2023

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SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

Cell death & disease, 2021-02, Vol.12 (2), p.165-17, Article 165

2021

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Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

PloS one, 2016-02, Vol.11 (2), p.e0148762-e0148762

2016

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YmdB Phosphodiesterase Is a Global Regulator of Late Adaptive Responses in Bacillus subtilis

Journal of Bacteriology, 2014-01, Vol.196 (2), p.265-275

2014

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Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition

Biochemical Society transactions, 2014-02, Vol.42 (1), p.130-138

2014

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Unusual, Dual Endo- and Exonuclease Activity in the Degradosome Explained by Crystal Structure Analysis of RNase J1

Structure (London), 2011-09, Vol.19 (9), p.1241-1251

2011

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Molecular Architecture of the "Stressosome," a Signal Integration and Transduction Hub

Science (American Association for the Advancement of Science), 2008-10, Vol.322 (5898), p.92-96

2008

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Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev

The Journal of biological chemistry, 2015-05, Vol.290 (22), p.13692-13709

2015

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The Bacterial Stressosome: A Modular System that Has Been Adapted to Control Secondary Messenger Signaling

Structure (London), 2012-02, Vol.20 (2), p.350-363

2012

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Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5

Nucleic acids research, 2017-04, Vol.45 (7), p.4231

2017

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The SNM1A DNA repair nuclease

DNA repair, 2020-11, Vol.95, p.102941-102941, Article 102941

2020

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A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin

Structure (London), 2019-08, Vol.27 (8), p.1316-1325.e6

2019

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The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity

The Journal of biological chemistry, 2020-03, Vol.295 (10), p.2948-2958

2020

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Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes

The Journal of biological chemistry, 2018-08, Vol.293 (33), p.12862-12876

2018

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Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

RecQ helicases in DNA repair and cancer targets

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Molecular Basis of the Activity of SinR Protein, the Master Regulator of Biofilm Formation in Bacillus subtilis

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family

Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

SNM1A is crucial for efficient repair of complex DNA breaks in human cells

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development

SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

YmdB Phosphodiesterase Is a Global Regulator of Late Adaptive Responses in Bacillus subtilis

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition

Unusual, Dual Endo- and Exonuclease Activity in the Degradosome Explained by Crystal Structure Analysis of RNase J1

Molecular Architecture of the "Stressosome," a Signal Integration and Transduction Hub

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev

The Bacterial Stressosome: A Modular System that Has Been Adapted to Control Secondary Messenger Signaling

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5

The SNM1A DNA repair nuclease

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity

Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes

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