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ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation

International journal of molecular sciences, 2020-07, Vol.21 (14), p.5133

2020

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ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling

The Journal of experimental medicine, 2018-04, Vol.215 (4), p.1205-1225

2018

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The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo

The Journal of biological chemistry, 2022-06, Vol.298 (6), p.101910, Article 101910

2022

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The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

Molecular neurodegeneration, 2023-02, Vol.18 (1), p.13-13, Article 13

2023

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ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer

Biochimica et biophysica acta. Molecular cell research, 2022-01, Vol.1869 (1), p.119141, Article 119141

2022

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ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer

Cancers, 2019-11, Vol.11 (11), p.1736

2019

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A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

Bone Research, 2020-06, Vol.8 (1), p.24-24, Article 24

2020

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Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

Blood, 2020-10, Vol.136 (18), p.2051-2064

2020

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EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells

Biochimica et biophysica acta. Molecular cell research, 2023-10, Vol.1870 (7), p.119489-119489, Article 119489

2023

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Gut microbiota shape ‘inflamm-ageing’ cytokines and account for age-dependent decline in DNA damage repair

Gut, 2020-06, Vol.69 (6), p.1064-1075

2020

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Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis

The Journal of experimental medicine, 2022-01, Vol.219 (1)

2022

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Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles

The Journal of biological chemistry, 2015-10, Vol.290 (43), p.26059-26071

2015

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ADAM17 controls IL‐6 signaling by cleavage of the murine IL‐6Rα from the cell surface of leukocytes during inflammatory responses

Journal of leukocyte biology, 2016-05, Vol.99 (5), p.749-760

2016

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Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation

The Journal of immunology (1950), 2023-06, Vol.210 (11), p.1717-1727

2023

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Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling

Scientific reports, 2017-03, Vol.7 (1), p.44053-44053, Article 44053

2017

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Proteolytic Cleavage Governs Interleukin-11 Trans-signaling

Cell reports (Cambridge), 2016-02, Vol.14 (7), p.1761-1773

2016

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Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation

The Journal of immunology (1950), 2016-11, Vol.197 (9), p.3705-3715

2016

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Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice

Journal of hepatology, 2021-02, Vol.74 (2), p.407-418

2021

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Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells

The Journal of immunology (1950), 2018-11, Vol.201 (10), p.3106-3118

2018

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Enzymatic characterization of novel arylsulfatase A variants using human arylsulfatase A‐deficient immortalized mesenchymal stromal cells

Human mutation, 2017-11, Vol.38 (11), p.1511-1520

2017

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Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro

Oncotarget, 2017-08, Vol.8 (33), p.54873-54888

2017

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A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

骨研究（英文版）, 2020, Vol.8 (2), p.157-168

2020

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Functional role of inositol‐1,4,5‐trisphosphate‐3‐kinase‐A for motility of malignant transformed cells

International journal of cancer, 2011-09, Vol.129 (6), p.1300-1309

2011

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ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation

ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling

The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo

The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer

ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells

Gut microbiota shape ‘inflamm-ageing’ cytokines and account for age-dependent decline in DNA damage repair

Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis

Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles

ADAM17 controls IL‐6 signaling by cleavage of the murine IL‐6Rα from the cell surface of leukocytes during inflammatory responses

Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling

Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation

Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice

Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells

Enzymatic characterization of novel arylsulfatase A variants using human arylsulfatase A‐deficient immortalized mesenchymal stromal cells

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

Functional role of inositol‐1,4,5‐trisphosphate‐3‐kinase‐A for motility of malignant transformed cells

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