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Domino Reactions Enable Zn-Mediated Direct Synthesis of Spiro-Fused 2-Oxindole-α-Methylene-γ-Butyrolactones/Lactams from Isatin Derivatives and 2-(Bromomethyl)acrylates

Molecules (Basel, Switzerland), 2024-07, Vol.29 (15), p.3612

2024

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Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC)

Chemical communications (Cambridge, England), 2017-07, Vol.53 (54), p.7577-7580

2017

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Face selective reduction of the exocyclic double bond in isatin derived spirocyclic lactones

Organic & biomolecular chemistry, 2013-01, Vol.11 (2), p.244-247

2013

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Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation

Signal transduction and targeted therapy, 2021-04, Vol.6 (1), p.142-142, Article 142

2021

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PROTACs in Ovarian Cancer: Current Advancements and Future Perspectives

International journal of molecular sciences, 2024-05, Vol.25 (10), p.5067

2024

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DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

eLife, 2024-07, Vol.12

2024

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Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase

Cancers, 2021-11, Vol.13 (21), p.5506

2021

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Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Nature communications, 2019-09, Vol.10 (1), p.4374-16, Article 4374

2019

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Protein tyrosine kinase regulation by ubiquitination: Critical roles of Cbl-family ubiquitin ligases

Biochimica et biophysica acta, 2013-01, Vol.1833 (1), p.122-139

2013

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Protein kinase RNA-activated controls mitotic progression and determines paclitaxel chemosensitivity through B-cell lymphoma 2 in ovarian cancer

Oncogene, 2021-12, Vol.40 (50), p.6772-6785

2021

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Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction

PloS one, 2021-03, Vol.16 (3), p.e0248941-e0248941

2021

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Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity

Molecular and cellular biology, 2017-03, Vol.37 (6)

2017

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PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells

Cancers, 2021-04, Vol.13 (9), p.2168

2021

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A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Nature communications, 2019-09, Vol.10 (1), p.4252-13, Article 4252

2019

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GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior

Scientific reports, 2024-06, Vol.14 (1), p.13523-19

2024

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Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior

Frontiers in pharmacology, 2022-05, Vol.13, p.863762

2022

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Cdk5 mediates rotational force-induced brain injury

Scientific reports, 2023-02, Vol.13 (1), p.3394-20, Article 3394

2023

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Recent Advances in Cancer Drug Development: Targeting Induced Myeloid Cell Leukemia-1 (Mcl-1) Differentiation Protein

Current medicinal chemistry, 2017-01, Vol.24 (40), p.4488-4514

2017

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A Kinase Inhibitor Screen Reveals Protein Kinase C-dependent Endocytic Recycling of ErbB2 in Breast Cancer Cells

The Journal of biological chemistry, 2014-10, Vol.289 (44), p.30443-30458

2014

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Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective

Cells (Basel, Switzerland), 2019-11, Vol.8 (11), p.1462

2019

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Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design

PLoS computational biology, 2016-08, Vol.12 (8), p.e1005057-e1005057

2016

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The Novel Anti-Cancer Agent, SpiD3, Is Cytotoxic in CLL Cells Resistant to Ibrutinib or Venetoclax

Hemato, 2024-08, Vol.5 (3), p.321-340

2024

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Explorations of Substituted Urea Functionality for the Discovery of New Activators of the Heme-Regulated Inhibitor Kinase

Journal of medicinal chemistry, 2013-12, Vol.56 (23), p.9457-9470

2013

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Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

Cancer biology & therapy, 2011-01, Vol.11 (2), p.263-276

2011

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High-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity

Analytical biochemistry, 2013-09, Vol.440 (1), p.71-77

2013

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Domino Reactions Enable Zn-Mediated Direct Synthesis of Spiro-Fused 2-Oxindole-α-Methylene-γ-Butyrolactones/Lactams from Isatin Derivatives and 2-(Bromomethyl)acrylates

Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC)

Face selective reduction of the exocyclic double bond in isatin derived spirocyclic lactones

Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation

PROTACs in Ovarian Cancer: Current Advancements and Future Perspectives

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Protein tyrosine kinase regulation by ubiquitination: Critical roles of Cbl-family ubiquitin ligases

Protein kinase RNA-activated controls mitotic progression and determines paclitaxel chemosensitivity through B-cell lymphoma 2 in ovarian cancer

Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction

Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity

PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior

Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior

Cdk5 mediates rotational force-induced brain injury

Recent Advances in Cancer Drug Development: Targeting Induced Myeloid Cell Leukemia-1 (Mcl-1) Differentiation Protein

A Kinase Inhibitor Screen Reveals Protein Kinase C-dependent Endocytic Recycling of ErbB2 in Breast Cancer Cells

Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective

Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design

The Novel Anti-Cancer Agent, SpiD3, Is Cytotoxic in CLL Cells Resistant to Ibrutinib or Venetoclax

Explorations of Substituted Urea Functionality for the Discovery of New Activators of the Heme-Regulated Inhibitor Kinase

Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

High-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity

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