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Modulation of the G‑Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists

Journal of medicinal chemistry, 2020-12, Vol.63 (24), p.15399-15409

2020

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Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84

Nature communications, 2023-06, Vol.14 (1), p.3271-3271, Article 3271

2023

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Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue

Acta pharmacologica Sinica, 2021-06, Vol.42 (6), p.964-974

2021

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Discovery of Novel Long‐Chain Alkenyl Diacid Derivatives as ACLY Inhibitors

Chinese journal of chemistry, 2022-11, Vol.40 (22), p.2663-2670

2022

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Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells

Acta pharmacologica Sinica, 2020-06, Vol.41 (6), p.813-824

2020

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Synthesis and Structure‐Activity Relationships of Ring‐Opened Bengamide Analogues against Methicillin‐Resistant Staphylococcus aureus

Chinese journal of chemistry, 2021-03, Vol.39 (3), p.671-676

2021

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AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models

Acta pharmacologica Sinica, 2021-04, Vol.42 (4), p.585-592

2021

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Discovery of a novel calcium-sensitive fluorescent probe for α-ketoglutarate

Acta pharmacologica Sinica, 2017-12, Vol.38 (12), p.1683-1690

2017

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Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (21), p.8726-8731

2013

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Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux

Acta pharmacologica Sinica, 2019-07, Vol.40 (7), p.908-918

2019

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Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK

Biochimica et biophysica acta, 2006-11, Vol.1760 (11), p.1682-1689

2006

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Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

The Journal of biological chemistry, 2008-06, Vol.283 (23), p.16051-16060

2008

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Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core

Acta pharmacologica Sinica, 2020-03, Vol.41 (3), p.293-302

2020

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Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma

Acta pharmacologica Sinica, 2022-04, Vol.43 (4), p.1091-1099

2022

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Design, Synthesis and Biological Evaluation of Bengamide Analogues as ClpP Activators

Chinese journal of chemistry, 2020-10, Vol.38 (10), p.1111-1115

2020

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Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice

Toxicology and applied pharmacology, 2013-12, Vol.273 (2), p.325-334

2013

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Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation

Acta pharmacologica Sinica, 2014-03, Vol.35 (3), p.410-418

2014

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Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2)

Organic & biomolecular chemistry, 2016-01, Vol.14 (2), p.747-751

2016

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Effect of a hepatitis B virus inhibitor, NZ-4, on capsid formation

Antiviral research, 2016-01, Vol.125, p.25-33

2016

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Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy

Acta pharmacologica Sinica, 2014-11, Vol.35 (11), p.1463-1472

2014

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Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.3991-4006

2022

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Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice

Acta pharmacologica Sinica, 2018-10, Vol.39 (10), p.1622-1632

2018

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Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp- based high-throughput screening techniques

Acta pharmacologica Sinica, 2016-01, Vol.37 (1), p.105-110

2016

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AMPK activators as novel therapeutics for type 2 diabetes

Current topics in medicinal chemistry, 2010-03, Vol.10 (4), p.397

2010

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AICAR Induces Astroglial Differentiation of Neural Stem Cells via Activating the JAK/STAT3 Pathway Independently of AMP-activated Protein Kinase

The Journal of biological chemistry, 2008-03, Vol.283 (10), p.6201-6208

2008

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Modulation of the G‑Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists

Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84

Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue

Discovery of Novel Long‐Chain Alkenyl Diacid Derivatives as ACLY Inhibitors

Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells

Synthesis and Structure‐Activity Relationships of Ring‐Opened Bengamide Analogues against Methicillin‐Resistant Staphylococcus aureus

AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models

Discovery of a novel calcium-sensitive fluorescent probe for α-ketoglutarate

Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels

Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux

Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK

Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma

Design, Synthesis and Biological Evaluation of Bengamide Analogues as ClpP Activators

Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice

Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation

Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2)

Effect of a hepatitis B virus inhibitor, NZ-4, on capsid formation

Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy

Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis

Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice

Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp- based high-throughput screening techniques

AMPK activators as novel therapeutics for type 2 diabetes

AICAR Induces Astroglial Differentiation of Neural Stem Cells via Activating the JAK/STAT3 Pathway Independently of AMP-activated Protein Kinase

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