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Necroptosis in development and diseases

Genes & development, 2018-03, Vol.32 (5-6), p.327-340

2018

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Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model

Nature communications, 2020-11, Vol.11 (1), p.5731-5731, Article 5731

2020

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Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

Protein & cell, 2021-10, Vol.12 (10), p.769-787

2021

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ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation

Nature communications, 2021-04, Vol.12 (1), p.2346-14, Article 2346

2021

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Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

Nature communications, 2017-08, Vol.8 (1), p.359-12, Article 359

2017

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RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

Science (American Association for the Advancement of Science), 2016-08, Vol.353 (6299), p.603-608

2016

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NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation

Nature communications, 2021-08, Vol.12 (1), p.4826-19, Article 4826

2021

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Western Blotting Guru

1, 2017

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CrossCheck: an open-source web tool for high-throughput screen data analysis

Scientific reports, 2017-07, Vol.7 (1), p.5855-4, Article 5855

2017

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Activation of Necroptosis in Multiple Sclerosis

Cell reports (Cambridge), 2015-03, Vol.10 (11), p.1836-1849

2015

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ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC

Nature cell biology, 2018-01, Vol.20 (1), p.58-68

2018

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RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

Molecular cell, 2021-01, Vol.81 (2), p.370-385.e7

2021

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BRAF and AXL oncogenes drive RIPK3 expression loss in cancer

PLoS biology, 2018-08, Vol.16 (8), p.e2005756-e2005756

2018

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ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner

Cell death and differentiation, 2019-06, Vol.26 (6), p.1077-1088

2019

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Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

The Journal of cell biology, 2015-08, Vol.210 (5), p.705-716

2015

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G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L

eLife, 2015-03, Vol.4, p.e06734-e06734

2015

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Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3

Cell death & disease, 2019-12, Vol.10 (12), p.923-13, Article 923

2019

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Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

Biochemical journal, 2011-01, Vol.433 (2), p.357-369

2011

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Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death

Cell death & disease, 2018-01, Vol.9 (2), p.138-14, Article 138

2018

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The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

eLife, 2016-04, Vol.5

2016

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Uncoupling the Warburg effect from cancer

Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (45), p.19135-19136

2010

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GECO: gene expression correlation analysis after genetic algorithm-driven deconvolution

Bioinformatics, 2019-01, Vol.35 (1), p.156-159

2019

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PCR Guru: An Ultimate Benchtop Reference for Molecular Biologists

Ayaz Najafov, Gerta Hoxhaj

1, 2016

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The UNC-45 Chaperone Mediates Sarcomere Assembly through Myosin Degradation in Caenorhabditis elegans

The Journal of cell biology, 2007-04, Vol.177 (2), p.205-210

2007

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Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors

Biochemical journal, 2012-12, Vol.448 (2), p.285-295

2012

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Necroptosis in development and diseases

Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model

Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation

Western Blotting Guru

CrossCheck: an open-source web tool for high-throughput screen data analysis

Activation of Necroptosis in Multiple Sclerosis

ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC

RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer

ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner

Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L

Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

Uncoupling the Warburg effect from cancer

GECO: gene expression correlation analysis after genetic algorithm-driven deconvolution

PCR Guru: An Ultimate Benchtop Reference for Molecular Biologists

The UNC-45 Chaperone Mediates Sarcomere Assembly through Myosin Degradation in Caenorhabditis elegans

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors

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