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Long-Term Nonclinical Pulmonary Safety Assessment of Afrezza, a Novel Insulin Inhalation Powder

Toxicologic pathology, 2021-02, Vol.49 (2), p.334-348

2021

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Regulatory Forum Opinion Piece: An Experienced Pathologist Need Not Always Be Present at Necropsy for Small Molecule or Biotherapeutic Safety Studies

Toxicologic pathology, 2016-01, Vol.44 (1), p.12-13

Nikula, Kristen J.

2016

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International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis)

Journal of Toxicologic Pathology, 2021, Vol.34(3_Suppl), pp.1S-182S

2021

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Regulatory Forum Opinion Piece: An Experienced Pathologist Should Be Present at Necropsy for Novel Medical Device Studies

Toxicologic pathology, 2016-01, Vol.44 (1), p.9-11

2016

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Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFβ pathway inhibition

Toxicology and applied pharmacology, 2022-03, Vol.438, p.115905-115905, Article 115905

2022

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Symposium Summary: Breathe In, Breathe Out, Its Easy: What You Need to Know About Developing Inhaled Drugs

International journal of toxicology, 2016-07, Vol.35 (4), p.376-392

2016

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Intermittent convection-enhanced delivery of GDNF into rhesus monkey putamen: absence of local or cerebellar toxicity

Archives of toxicology, 2018-07, Vol.92 (7), p.2353-2367

2018

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BSTP Review of 12 Case Studies Discussing the Challenges, Pathology, Immunogenicity, and Mechanisms of Inhaled Biologics

Toxicologic pathology, 2021-02, Vol.49 (2), p.235-260

2021

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STP Position Paper: Interpreting the Significance of Increased Alveolar Macrophages in Rodents Following Inhalation of Pharmaceutical Materials

Toxicologic pathology, 2014-04, Vol.42 (3), p.472-486

2014

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Regulatory Forum Opinion Piece: Blind Reading of Histopathology Slides in General Toxicology Studies

Toxicologic pathology, 2012-06, Vol.40 (4), p.697-699

2012

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C-122, a novel antagonist of serotonin receptor 5-HT2B, prevents monocrotaline-induced pulmonary arterial hypertension in rats

European journal of pharmacology, 2011-11, Vol.670 (1), p.195-203

2011

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Mutagenicity and in Vivo Toxicity of Combined Particulate and Semivolatile Organic Fractions of Gasoline and Diesel Engine Emissions

Toxicological sciences, 2002-12, Vol.70 (2), p.212-226

2002

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RAT LUNG TUMORS INDUCED BY EXPOSURE TO SELECTED POORLY SOLUBLE NONFIBROUS PARTICLES

Inhalation toxicology, 2000, Vol.12 (1-2), p.97-119

Nikula, Kristen J.

2000

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Increased Cytosine DNA-Methyltransferase Activity is Target-Cell-Specific and an Early Event in Lung Cancer

Proceedings of the National Academy of Sciences - PNAS, 1996-04, Vol.93 (9), p.4045-4050

1996

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EFFECTS OF CIGARETTE SMOKE EXPOSURE AND CESSATION ON INFLAMMATORY CELLS AND MATRIX METALLOPROTEINASE ACTIVITY IN MICE

Experimental lung research, 2004, Vol.30 (1), p.1-15

2004

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Aberrant CpG island methylation of the p16(INK4a) and estrogen receptor genes in rat lung tumors induced by particulate carcinogens

Carcinogenesis (New York), 2002-02, Vol.23 (2), p.335

2002

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Influence of Exposure Concentration or Dose on the Distribution of Particulate Material in Rat and Human Lungs

Environmental health perspectives, 2001-04, Vol.109 (4), p.311-318

2001

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Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses

Advanced drug delivery reviews, 2014-05, Vol.71, p.15-33

2014

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ANIMAL MODELS OF CHRONIC BRONCHITIS AND THEIR RELEVANCE TO STUDIES OF PARTICLE-INDUCED DISEASE

Inhalation toxicology, 2000, Vol.12 (S4), p.123-153

2000

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Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis

Proceedings of the National Academy of Sciences - PNAS, 1998-09, Vol.95 (20), p.11891

1998

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Recommendation of Optimal Method for Formalin Fixation of Rodent Lungs in Routine Toxicology Studies

Toxicologic pathology, 2001-09, Vol.29 (5), p.587-589

2001

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ANIMAL MODELS OF EMPHYSEMA AND THEIR RELEVANCE TO STUDIES OF PARTICLE-INDUCED DISEASE

Inhalation toxicology, 2000, Vol.12 (S4), p.155-187

2000

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Aberrant CpG island methylation of the p16INK4a and estrogen receptor genes in rat lung tumors induced by particulate carcinogens

Carcinogenesis (New York), 2002-02, Vol.23 (2), p.335-339

2002

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Long-Term Nonclinical Pulmonary Safety Assessment of Afrezza, a Novel Insulin Inhalation Powder

Regulatory Forum Opinion Piece: An Experienced Pathologist Need Not Always Be Present at Necropsy for Small Molecule or Biotherapeutic Safety Studies

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis)

Regulatory Forum Opinion Piece: An Experienced Pathologist Should Be Present at Necropsy for Novel Medical Device Studies

Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFβ pathway inhibition

Symposium Summary: Breathe In, Breathe Out, Its Easy: What You Need to Know About Developing Inhaled Drugs

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog

Intermittent convection-enhanced delivery of GDNF into rhesus monkey putamen: absence of local or cerebellar toxicity

BSTP Review of 12 Case Studies Discussing the Challenges, Pathology, Immunogenicity, and Mechanisms of Inhaled Biologics

STP Position Paper: Interpreting the Significance of Increased Alveolar Macrophages in Rodents Following Inhalation of Pharmaceutical Materials

Regulatory Forum Opinion Piece: Blind Reading of Histopathology Slides in General Toxicology Studies

C-122, a novel antagonist of serotonin receptor 5-HT2B, prevents monocrotaline-induced pulmonary arterial hypertension in rats

Mutagenicity and in Vivo Toxicity of Combined Particulate and Semivolatile Organic Fractions of Gasoline and Diesel Engine Emissions

RAT LUNG TUMORS INDUCED BY EXPOSURE TO SELECTED POORLY SOLUBLE NONFIBROUS PARTICLES

Increased Cytosine DNA-Methyltransferase Activity is Target-Cell-Specific and an Early Event in Lung Cancer

EFFECTS OF CIGARETTE SMOKE EXPOSURE AND CESSATION ON INFLAMMATORY CELLS AND MATRIX METALLOPROTEINASE ACTIVITY IN MICE

Aberrant CpG island methylation of the p16(INK4a) and estrogen receptor genes in rat lung tumors induced by particulate carcinogens

Influence of Exposure Concentration or Dose on the Distribution of Particulate Material in Rat and Human Lungs

Acute Lymphoid and Gastrointestinal Toxicity Induced by Selective p38α Map Kinase and Map Kinase–Activated Protein Kinase-2 (MK2) Inhibitors in the Dog

Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses

ANIMAL MODELS OF CHRONIC BRONCHITIS AND THEIR RELEVANCE TO STUDIES OF PARTICLE-INDUCED DISEASE

Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis

Recommendation of Optimal Method for Formalin Fixation of Rodent Lungs in Routine Toxicology Studies

ANIMAL MODELS OF EMPHYSEMA AND THEIR RELEVANCE TO STUDIES OF PARTICLE-INDUCED DISEASE

Aberrant CpG island methylation of the p16INK4a and estrogen receptor genes in rat lung tumors induced by particulate carcinogens

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