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The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-α and MMP13

Osteoarthritis and cartilage, 2009-04, Vol.17 (4), p.464-472

2009

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Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology

Osteoarthritis and cartilage, 2009-01, Vol.17 (1), p.124-131

2009

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The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover

Osteoarthritis and cartilage, 2006-06, Vol.14 (6), p.597-608

2006

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Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Annual review of pharmacology and toxicology, 2018-01, Vol.58, p.65

2018

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Characterisation of cell‐penetrating peptide‐mediated peptide delivery

British journal of pharmacology, 2005-08, Vol.145 (8), p.1093-1102

2005

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210 MICRORNA ARE DIFFERENTIALLY EXPRESSED IN OSTEOARTHRITIC TISSUE

Osteoarthritis and cartilage, 2007, Vol.15, p.C122-C122

2007

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Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized

Arthritis research & therapy, 2009-01, Vol.11 (1), p.R11-R11

2009

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218 CANONICAL WNT EXPRESSION IN THE SYNOVIUM INDUCES OA-LIKE CARTILAGE DEGENERATION

Osteoarthritis and cartilage, 2009, Vol.17, p.S123-S124

2009

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154 MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE 2 MODULATES THE CYTOKINE-INDUCED PRODUCTION OF MATRIX METALLOPROTEASES AND THE PUTATIVE PAIN MEDIATOR PGE2 IN HUMAN OSTEOARTHRITIC CHONDROCYTES

Osteoarthritis and cartilage, 2007, Vol.15, p.C93-C94

2007

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12 BONE MARROW LESIONS FROM OSTEOARTHRITIS KNEES ARE CHARACTERIZED BY SCLEROTIC BONE THAT IS LESS WELL MINERALIZED

Osteoarthritis and cartilage, 2007, Vol.15, p.C21-C21

2007

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A34 WNT-1 INDUCED SECRETED PROTEIN 1 IS EXPRESSED IN OA AND INDUCES CARTILAGE DEGRADATION INDEPENDENT OF INTERLEUKIN-1

Osteoarthritis and cartilage, 2008, Vol.16, p.S28-S28

2008

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308 ALTERED PERFUSION AND VENOUS HYPERTENSION IS PRESENT IN REGIONS OF BONE AFFECTED BY BMLS IN KNEE OA

Osteoarthritis and cartilage, 2007, Vol.15, p.C171-C172

2007

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9 A PROMINENT ROLE FOR WNT-1 INDUCED SECRETED PROTEIN 1 AND UPREGULATION OF SEVERAL WNT GENES IN EXPERIMENTAL AND HUMAN OSTEOARTHRITIS

Osteoarthritis and cartilage, 2007, Vol.15, p.C19-C20

2007

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Novel ultrawide-bandwidth Vivaldi antenna with low crosspolarisation

Electronics letters, 1993, Vol.29 (23), p.2004-2005

1993

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Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1

The Journal of biological chemistry, 1994-02, Vol.269 (6), p.4005-4011

1994

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150 INVESTIGATING WNT1 INDUCIBLE SECRETED PROTEIN 3 IN OSTEOARTHRITIS AND CHONDROCYTE BIOLOGY

Osteoarthritis and cartilage, 2007, Vol.15, p.C91-C92

2007

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A dominant negative form of IKK2 prevents suppression of apoptosis by the peroxisome proliferator nafenopin

Carcinogenesis (New York), 2000-09, Vol.21 (9), p.1757-1760

2000

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AZD9773 is a novel and potent anti-TNFα polyclonal ovine immune Fab

Critical care (London, England), 2011-01, Vol.15 (S1), p.P261-P261, Article P261

2011

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Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (11), p.2817-2822

2004

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AZD9773, a novel anti-TNFα immune Fab in development for severe sepsis and septic shock: demonstration of safety and efficacy in a murine CLP sepsis model

Critical care (London, England), 2011-01, Vol.15 (S3), p.P41-P41, Article P41

2011

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The structure of cell-adhesion molecules

Trends in cell biology, 1998-02, Vol.8 (2), p.78-83

1998

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Preclinical pharmacodynamics and safety profiling of AZD9773: a novel anti-TNFα polyclonal immune ovine Fab similar to D-CytoFab

Critical care (London, England), 2011-01, Vol.15 (S1), p.P262-P262, Article P262

2011

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Identification of a key structural element in VCAM-1

Biochemical Society transactions, 1995-11, Vol.23 (4), p.512S

1995

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alpha 4 integrin binding interfaces on VCAM-1 and MAdCAM-1. Integrin binding footprints identify accessory binding sites that play a role in integrin specificity

The Journal of biological chemistry, 1997-08, Vol.272 (31), p.19429-19440

1997

Volltextzugriff (PDF)

Integrin adhesion receptors: structure, function and implications for biomedicine

Molecular Medicine Today, 1996-07, Vol.2 (7), p.304-313

1996

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The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-α and MMP13

Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology

The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Characterisation of cell‐penetrating peptide‐mediated peptide delivery

210 MICRORNA ARE DIFFERENTIALLY EXPRESSED IN OSTEOARTHRITIC TISSUE

Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized

218 CANONICAL WNT EXPRESSION IN THE SYNOVIUM INDUCES OA-LIKE CARTILAGE DEGENERATION

154 MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE 2 MODULATES THE CYTOKINE-INDUCED PRODUCTION OF MATRIX METALLOPROTEASES AND THE PUTATIVE PAIN MEDIATOR PGE2 IN HUMAN OSTEOARTHRITIC CHONDROCYTES

12 BONE MARROW LESIONS FROM OSTEOARTHRITIS KNEES ARE CHARACTERIZED BY SCLEROTIC BONE THAT IS LESS WELL MINERALIZED

A34 WNT-1 INDUCED SECRETED PROTEIN 1 IS EXPRESSED IN OA AND INDUCES CARTILAGE DEGRADATION INDEPENDENT OF INTERLEUKIN-1

308 ALTERED PERFUSION AND VENOUS HYPERTENSION IS PRESENT IN REGIONS OF BONE AFFECTED BY BMLS IN KNEE OA

9 A PROMINENT ROLE FOR WNT-1 INDUCED SECRETED PROTEIN 1 AND UPREGULATION OF SEVERAL WNT GENES IN EXPERIMENTAL AND HUMAN OSTEOARTHRITIS

Novel ultrawide-bandwidth Vivaldi antenna with low crosspolarisation

Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1

150 INVESTIGATING WNT1 INDUCIBLE SECRETED PROTEIN 3 IN OSTEOARTHRITIS AND CHONDROCYTE BIOLOGY

A dominant negative form of IKK2 prevents suppression of apoptosis by the peroxisome proliferator nafenopin

AZD9773 is a novel and potent anti-TNFα polyclonal ovine immune Fab

Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors

AZD9773, a novel anti-TNFα immune Fab in development for severe sepsis and septic shock: demonstration of safety and efficacy in a murine CLP sepsis model

The structure of cell-adhesion molecules

Preclinical pharmacodynamics and safety profiling of AZD9773: a novel anti-TNFα polyclonal immune ovine Fab similar to D-CytoFab

Identification of a key structural element in VCAM-1

alpha 4 integrin binding interfaces on VCAM-1 and MAdCAM-1. Integrin binding footprints identify accessory binding sites that play a role in integrin specificity

Integrin adhesion receptors: structure, function and implications for biomedicine

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