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Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1679-1683

2007

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Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease–helicase

Structure (London), 1999-11, Vol.7 (11), p.1353-1363

1999

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Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (17), p.4444-4449

2006

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Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (22), p.5888-5891

2006

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Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors

Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (10), p.3075-3080

2013

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Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1991-1995

2007

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A Novel Mechanism to Ensure Terminal Initiation by Hepatitis C Virus NS5B Polymerase

Virology (New York, N.Y.), 2001-06, Vol.285 (1), p.6-11

2001

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Structure of the hepatitis C virus RNA helicase domain

Nature structural & molecular biology, 1997-06, Vol.4 (6), p.463-467

1997

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Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5521-5527

2011

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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1838-1843

2011

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Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7303-7307

2010

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Isothiazoles as active-site inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.28-33

2007

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Potent 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid-Based Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease

Journal of medicinal chemistry, 2006-01, Vol.49 (2), p.567-574

2006

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Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.841-845

2007

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Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (16), p.4789-4794

2010

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region

Bioorganic & medicinal chemistry letters, 2010-10, Vol.20 (20), p.6034-6039

2010

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Novel Potent Hepatitis C Virus NS3 Serine Protease Inhibitors Derived from Proline-Based Macrocycles

Journal of medicinal chemistry, 2006-02, Vol.49 (3), p.995-1005

2006

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Crystal Structure of Complete Rhinovirus RNA Polymerase Suggests Front Loading of Protein Primer

Journal of Virology, 2005-01, Vol.79 (1), p.277-288

2005

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Design, Synthesis, and Biological Activity of m-Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6229-6235

2005

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Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (21), p.5561-5566

2006

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Replicon Cell Culture System as a Valuable Tool in Antiviral Drug Discovery against Hepatitis C Virus

Antiviral Chemistry and Chemotherapy, 2005-02, Vol.16 (1), p.1-12

2005

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Construction, expression, and characterization of a novel fully activated recombinant single‐chain hepatitis C virus protease

Protein science, 1998-10, Vol.7 (10), p.2143-2149

1998

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Refined 1.89-Å structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport/chemosensory proteins

Biochemistry (Easton), 1994-04, Vol.33 (16), p.4769-4779

1994

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Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as Hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (23), p.5751-5755

2004

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Synthesis of Tipranavir Analogues as Non-Peptidic HIV Protease Inhibitors

Letters in organic chemistry, 2009-03, Vol.6 (2), p.130-133

2009

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Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase

Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease–helicase

Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase

Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors

Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors

Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study

A Novel Mechanism to Ensure Terminal Initiation by Hepatitis C Virus NS5B Polymerase

Structure of the hepatitis C virus RNA helicase domain

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor

Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK

Isothiazoles as active-site inhibitors of HCV NS5B polymerase

Potent 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid-Based Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease

Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase

Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region

Novel Potent Hepatitis C Virus NS3 Serine Protease Inhibitors Derived from Proline-Based Macrocycles

Crystal Structure of Complete Rhinovirus RNA Polymerase Suggests Front Loading of Protein Primer

Design, Synthesis, and Biological Activity of m-Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease

Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors

Replicon Cell Culture System as a Valuable Tool in Antiviral Drug Discovery against Hepatitis C Virus

Construction, expression, and characterization of a novel fully activated recombinant single‐chain hepatitis C virus protease

Refined 1.89-Å structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport/chemosensory proteins

Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as Hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex

Synthesis of Tipranavir Analogues as Non-Peptidic HIV Protease Inhibitors

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