UB Paderborn / Katalog / Suche / in CDI

Sources of inter-individual variability leading to significant changes in anti-PD-1 and anti-PD-L1 efficacy identified in mouse tumor models using a QSP framework

Frontiers in pharmacology, 2022-12, Vol.13, p.1056365-1056365

2022

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A Quantitative Systems Pharmacology Model of Liver Lipid Metabolism for Investigation of Non-Alcoholic Fatty Liver Disease

Frontiers in pharmacology, 2022-07, Vol.13, p.910789-910789

2022

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A quantitative systems pharmacology model of the pathophysiology and treatment of COVID-19 predicts optimal timing of pharmacological interventions

NPJ systems biology and applications, 2023-04, Vol.9 (1), p.13-13, Article 13

2023

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Modeling is data driven: Use it for successful virtual patient generation

CPT: pharmacometrics and systems pharmacology, 2021-05, Vol.10 (5), p.393-394

2021

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A continuous-time Markov chain model of fibrosis progression in NAFLD and NASH

Frontiers in medicine, 2023, Vol.10, p.1130890-1130890

2023

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Analysis of compartments-in-series models of liver metabolism as partial differential equations: the effect of dispersion and number of compartments

Mathematical biosciences and engineering : MBE, 2019-01, Vol.16 (3), p.1082-1114

2019

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Requirements, expectations, challenges and opportunities associated with training the next generation of pharmacometricians

CPT: pharmacometrics and systems pharmacology, 2023-07, Vol.12 (7), p.883-888

2023

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End‐to‐end application of model‐informed drug development for ertugliflozin, a novel sodium‐glucose cotransporter 2 inhibitor

CPT: pharmacometrics and systems pharmacology, 2021-06, Vol.10 (6), p.529-542

2021

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Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies

PloS one, 2016-05, Vol.11 (5), p.e0155674

2016

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American Society for Clinical Pharmacology and Therapeutics 2019 Annual Meeting Pre‐Conferences

CPT: pharmacometrics and systems pharmacology, 2019-06, Vol.8 (6), p.333-335

2019

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Modeling fructose-load-induced hepatic de-novo lipogenesis by model simplification

Gene Regulation and Systems Biology, 2017-04, Vol.2017 (11), p.1177625017690133-1177625017690133

2017

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A mathematical analysis of adaptations to the metabolic fate of fructose in essential fructosuria subjects

American journal of physiology: endocrinology and metabolism, 2018-09, Vol.315 (3), p.E394-E403

2018

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Improving the generation and selection of virtual populations in quantitative systems pharmacology models

Progress in biophysics and molecular biology, 2018-11, Vol.139, p.15-22

2018

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A Prototype QSP Model of the Immune Response to SARS‐CoV‐2 for Community Development

CPT: pharmacometrics and systems pharmacology, 2021-01, Vol.10 (1), p.18-29

2021

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Quantitative analysis of variability in an integrated model of human ventricular electrophysiology and β-adrenergic signaling

Journal of molecular and cellular cardiology, 2020-06, Vol.143, p.96-106

2020

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Mechanistic systems modeling to guide drug discovery and development

Drug discovery today, 2013-02, Vol.18 (3-4), p.116-127

2013

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PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates

Journal of pharmacokinetics and pharmacodynamics, 2016-08, Vol.43 (4), p.411-425

2016

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Pool size measurements improve precision of flux estimates but increase sensitivity to unmodeled reactions outside the core network in isotopically nonstationary metabolic flux analysis (INST‐MFA)

Biotechnology journal, 2022-03, Vol.17 (3), p.e2000427-n/a

2022

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Transforming Translation Through Quantitative Pharmacology for High‐Impact Decision Making in Drug Discovery and Development

Clinical pharmacology and therapeutics, 2020-06, Vol.107 (6), p.1285-1289

2020

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FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective

The AAPS journal, 2021-04, Vol.23 (3), p.60-60, Article 60

2021

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Toward Progress in Quantitative Translational Medicine: A Call to Action

Clinical pharmacology and therapeutics, 2020-01, Vol.107 (1), p.85-88

2020

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Benefits and challenges of a QSP approach through case study: Evaluation of a hypothetical GLP-1/GIP dual agonist therapy

European journal of pharmaceutical sciences, 2016-10, Vol.94, p.15-19

2016

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A Survey of Software Tool Utilization and Capabilities for Quantitative Systems Pharmacology: What We Have and What We Need

CPT: pharmacometrics and systems pharmacology, 2019-02, Vol.8 (2), p.62-76

2019

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Perspective on the State of Pharmacometrics and Systems Pharmacology Integration

CPT: pharmacometrics and systems pharmacology, 2018-10, Vol.7 (10), p.617-620

2018

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Factors Affecting the Deposition of Inhaled Porous Drug Particles

Journal of pharmaceutical sciences, 2002-07, Vol.91 (7), p.1590-1600

2002

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Sources of inter-individual variability leading to significant changes in anti-PD-1 and anti-PD-L1 efficacy identified in mouse tumor models using a QSP framework

A Quantitative Systems Pharmacology Model of Liver Lipid Metabolism for Investigation of Non-Alcoholic Fatty Liver Disease

A quantitative systems pharmacology model of the pathophysiology and treatment of COVID-19 predicts optimal timing of pharmacological interventions

Modeling is data driven: Use it for successful virtual patient generation

A continuous-time Markov chain model of fibrosis progression in NAFLD and NASH

Analysis of compartments-in-series models of liver metabolism as partial differential equations: the effect of dispersion and number of compartments

Requirements, expectations, challenges and opportunities associated with training the next generation of pharmacometricians

End‐to‐end application of model‐informed drug development for ertugliflozin, a novel sodium‐glucose cotransporter 2 inhibitor

Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies

American Society for Clinical Pharmacology and Therapeutics 2019 Annual Meeting Pre‐Conferences

Modeling fructose-load-induced hepatic de-novo lipogenesis by model simplification

A mathematical analysis of adaptations to the metabolic fate of fructose in essential fructosuria subjects

Improving the generation and selection of virtual populations in quantitative systems pharmacology models

A Prototype QSP Model of the Immune Response to SARS‐CoV‐2 for Community Development

Quantitative analysis of variability in an integrated model of human ventricular electrophysiology and β-adrenergic signaling

Mechanistic systems modeling to guide drug discovery and development

PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates

Pool size measurements improve precision of flux estimates but increase sensitivity to unmodeled reactions outside the core network in isotopically nonstationary metabolic flux analysis (INST‐MFA)

Transforming Translation Through Quantitative Pharmacology for High‐Impact Decision Making in Drug Discovery and Development

FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective

Toward Progress in Quantitative Translational Medicine: A Call to Action

Benefits and challenges of a QSP approach through case study: Evaluation of a hypothetical GLP-1/GIP dual agonist therapy

A Survey of Software Tool Utilization and Capabilities for Quantitative Systems Pharmacology: What We Have and What We Need

Perspective on the State of Pharmacometrics and Systems Pharmacology Integration

Factors Affecting the Deposition of Inhaled Porous Drug Particles

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