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Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells

Cancer research (Chicago, Ill.), 2007-01, Vol.67 (2), p.746-755

2007

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The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions

Microvascular research, 2009-03, Vol.77 (2), p.78-86

2009

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Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma

Blood, 2001-07, Vol.98 (1), p.210-216

2001

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Thalidomide and Lenalidomide Extend Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

The Journal of neuroscience, 2006-03, Vol.26 (9), p.2467-2473

2006

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Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.360-365

2013

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Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.1222

2003

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1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4

Bioorganic & medicinal chemistry, 2011-11, Vol.19 (21), p.6356-6374

2011

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CC-5079: A Small Molecule with MKP1, Antiangiogenic, and Antitumor Activity

The Journal of surgical research, 2010-11, Vol.164 (1), p.116-125

2010

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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Combination therapy targeting the tumor microenvironment is effective in a model of human ocular melanoma

Journal of translational medicine, 2007-07, Vol.5 (1), p.38-38, Article 38

2007

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Pomalidomide and Lenalidomide Induce p21WAF-1 Expression in Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism

Cancer research (Chicago, Ill.), 2009-09, Vol.69 (18), p.7347-7356

2009

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Protective Antitumor Immunity Induced by a Costimulatory Thalidomide Analog in Conjunction with Whole Tumor Cell Vaccination Is Mediated by Increased Th1-Type Immunity

The Journal of immunology (1950), 2002-05, Vol.168 (10), p.4914-4919

2002

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A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay

Journal of translational medicine, 2004-01, Vol.2 (1), p.4-4

2004

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The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-α production with antitumor activity

Cancer research (Chicago, Ill.), 2006-01, Vol.66 (2), p.951-959

2006

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Chiral inversion of the second generation IMiD™ CC-4047 (ACTIMID™) in human plasma and phosphate-buffered saline

Chirality (New York, N.Y.), 2003, Vol.15 (4), p.348-351

2003

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Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells

Pancreas, 2009-01, Vol.38 (1), p.78-84

2009

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α-Fluoro-substituted thalidomide analogues

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (20), p.3415-3417

2003

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A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins

Cancer research (Chicago, Ill.), 2003-02, Vol.63 (3), p.593-599

2003

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Structural Modifications of Thalidomide Produce Analogs with Enhanced Tumor Necrosis Factor Inhibitory Activity

Journal of medicinal chemistry, 1996-08, Vol.39 (17), p.3238-3240

1996

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Effect of 3-fluorothalidomide and 3-methylthalidomide enantiomers on tumor necrosis factor production and antitumor responses to the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

Oncology research, 2003, Vol.14 (2), p.75

2003

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A Concise Two-Step Synthesis of Thalidomide

Organic process research & development, 1999-03, Vol.3 (2), p.139-140

1999

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Selective cytokine inhibitory drugs with enhanced antiangiogenic activity control tumor growth through vascular inhibition

Cancer research (Chicago, Ill.), 2003-12, Vol.63 (23), p.8073-8078

2003

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Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha

The Journal of immunology (1950), 1999-07, Vol.163 (1), p.380-386

1999

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Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production

Bioorganic & medicinal chemistry letters, 1999-06, Vol.9 (11), p.1625-1630

1999

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Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells

The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions

Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma

Thalidomide and Lenalidomide Extend Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs

1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4

CC-5079: A Small Molecule with MKP1, Antiangiogenic, and Antitumor Activity

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor

Combination therapy targeting the tumor microenvironment is effective in a model of human ocular melanoma

Pomalidomide and Lenalidomide Induce p21WAF-1 Expression in Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism

Protective Antitumor Immunity Induced by a Costimulatory Thalidomide Analog in Conjunction with Whole Tumor Cell Vaccination Is Mediated by Increased Th1-Type Immunity

A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay

The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-α production with antitumor activity

Chiral inversion of the second generation IMiD™ CC-4047 (ACTIMID™) in human plasma and phosphate-buffered saline

Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells

α-Fluoro-substituted thalidomide analogues

A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins

Structural Modifications of Thalidomide Produce Analogs with Enhanced Tumor Necrosis Factor Inhibitory Activity

Effect of 3-fluorothalidomide and 3-methylthalidomide enantiomers on tumor necrosis factor production and antitumor responses to the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

A Concise Two-Step Synthesis of Thalidomide

Selective cytokine inhibitory drugs with enhanced antiangiogenic activity control tumor growth through vascular inhibition

Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha

Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production

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