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The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro‑2H‑pyran-4-yl)-1,3-dihydro‑2H‑imidazo[4,5‑c]quinolin-2-one)

Journal of medicinal chemistry, 2018-05, Vol.61 (9), p.3823-3841

2018

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An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines

ChemCatChem, 2015-02, Vol.7 (4), p.579-583

2015

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Biocatalytic N‑Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades

Journal of the American Chemical Society, 2019-01, Vol.141 (3), p.1201-1206

2019

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Bifunctional catalysis: direct reductive amination of aliphatic ketones with an iridium-phosphate catalyst

Molecules (Basel, Switzerland), 2010-04, Vol.15 (4), p.2453-2472

2010

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A Survey of the Borrowing Hydrogen Approach to the Synthesis of some Pharmaceutically Relevant Intermediates

Organic process research & development, 2015-10, Vol.19 (10), p.1400-1410

2015

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One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω‑Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

ACS catalysis, 2016-06, Vol.6 (6), p.3753-3759

2016

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Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N‑Heterocycles

ACS catalysis, 2024-10, Vol.14 (19), p.14703-14710

2024

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Development of a Chemoenzymatic Route to (R)‑Allyl-(3-amino-2-(2-methylbenzyl)propyl)carbamate

Organic process research & development, 2016-01, Vol.20 (1), p.65-69

2016

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Efficient Synthesis of (S)‑1-(5-Fluoropyrimidin-2-yl)ethylamine Using an ω‑Transaminase Biocatalyst in a Two-Phase System

Organic process research & development, 2013-09, Vol.17 (9), p.1117-1122

2013

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Use of ω‑Transaminase Enzyme Chemistry in the Synthesis of a JAK2 Kinase Inhibitor

Organic process research & development, 2013-09, Vol.17 (9), p.1123-1130

2013

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Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib

Organic process research & development, 2021-01, Vol.25 (1), p.43-56

2021

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(1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide

Journal of medicinal chemistry, 1993-12, Vol.36 (25), p.4121-4123

1993

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Studies into the asymmetric Meisenheimer rearrangement

Tetrahedron: asymmetry, 1998-06, Vol.9 (11), p.1995-2009

1998

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Development of a Catalytic Tributyltin Hydride Cyclisation Process

Organic process research & development, 2000-03, Vol.4 (2), p.98-101

2000

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C-nucleosides. Part 1. Preparation of tiazofurin and N-substituted tiazofurins from benzyl (2′,3′,5′-tri-O-benzoyl-β- D -ribofuranosyl)penicillinate

J. Chem. Soc., Perkin Trans. 1, 1990 (2), p.283-292

1990

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Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent

Journal of medicinal chemistry, 2000-03, Vol.43 (6), p.1123-1134

2000

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Biocatalysis for Industrial Process Development

Practical Methods for Biocatalysis and Biotransformations 3, 2016, p.1-1

2016

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Chirality Transfer from Nitrogen to Carbon in the [2,3]-Meisenheimer Rearrangement

Synlett, 1997-03, Vol.1997 (3), p.322-324

1997

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Meisenheimer rearrangements of N-allyl 2-azabornane derivatives

Journal of the Chemical Society, Perkin Transactions 1, 1999 (16), p.2327-2334

1999

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ChemInform Abstract: Meisenheimer Rearrangements of N-Allyl 2-Azabornane Derivatives

ChemInform, 1999-12, Vol.30 (50), p.no-no

1999

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The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro‑2H‑pyran-4-yl)-1,3-dihydro‑2H‑imidazo[4,5‑c]quinolin-2-one)

An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines

Biocatalytic N‑Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades

Bifunctional catalysis: direct reductive amination of aliphatic ketones with an iridium-phosphate catalyst

A Survey of the Borrowing Hydrogen Approach to the Synthesis of some Pharmaceutically Relevant Intermediates

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω‑Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N‑Heterocycles

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one)

Development of a Chemoenzymatic Route to (R)‑Allyl-(3-amino-2-(2-methylbenzyl)propyl)carbamate

Efficient Synthesis of (S)‑1-(5-Fluoropyrimidin-2-yl)ethylamine Using an ω‑Transaminase Biocatalyst in a Two-Phase System

Use of ω‑Transaminase Enzyme Chemistry in the Synthesis of a JAK2 Kinase Inhibitor

Biarylcarbamoylindolines Are Novel and Selective 5-HT2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent

Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib

(1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide

Studies into the asymmetric Meisenheimer rearrangement

Development of a Catalytic Tributyltin Hydride Cyclisation Process

C-nucleosides. Part 1. Preparation of tiazofurin and N-substituted tiazofurins from benzyl (2′,3′,5′-tri-O-benzoyl-β- D -ribofuranosyl)penicillinate

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent

Biocatalysis for Industrial Process Development

Chirality Transfer from Nitrogen to Carbon in the [2,3]-Meisenheimer Rearrangement

Meisenheimer rearrangements of N-allyl 2-azabornane derivatives

Biarylcarbamoylindolines Are Novel and Selective 5-HT 2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent

The Selective 5-HT1B Receptor Inverse Agonist 1‘-Methyl-5-[[2‘-methyl-4‘- (5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4‘-piperidine] (SB-224289) Potently Blocks Terminal 5-HT Autoreceptor Function Both in Vitro and in Vivo

The Selective 5-HT 1B Receptor Inverse Agonist 1‘-Methyl-5-[[2‘-methyl-4‘- (5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3- f ]indole-3,4‘-piperidine] (SB-224289) Potently Blocks Terminal 5-HT Autoreceptor Function Both in Vitro and in Vivo

ChemInform Abstract: Meisenheimer Rearrangements of N-Allyl 2-Azabornane Derivatives

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