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2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

Science (American Association for the Advancement of Science), 2016-02, Vol.351 (6275), p.871-875

2016

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Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

Journal of medicinal chemistry, 2011-09, Vol.54 (18), p.6342-6363

2011

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Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma

Molecular cancer therapeutics, 2007-12, Vol.6 (12), p.3314-3322

2007

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An orally available small-molecule inhibitor of c-met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms

Cancer research (Chicago, Ill.), 2007-05, Vol.67 (9), p.4408-4417

2007

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Sulforaphane is Synergistic with CB‐5083and Inhibits Colony Formation of CB‐5083‐Resistant HCT116 Cells

ChemMedChem, 2022-06, Vol.17 (11)

2022

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Molecular Dynamics Simulations for Improving Crystal Quality and Illuminating the Function of Taspase1: A Therapeutic Target

Biophysical journal, 2020-02, Vol.118 (3), p.507a-507a

2020

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Sulforaphane is Synergistic with CB‐5083 and Inhibits Colony Formation of CB‐5083‐Resistant HCT116 Cells

ChemMedChem, 2022-06, Vol.17 (11), p.e202200030-n/a

2022

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Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs

Molecular cancer therapeutics, 2022-10, Vol.21 (10), p.1510-1523

2022

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Using microgravity at the Inernational Space Station to lead to new therapeutics for Taspase1: a novel cancer target

Acta crystallographica. Section A, Foundations and advances, 2019-07, Vol.75 (a1), p.a110-a110

2019

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Structure-based design of novel human Pin1 inhibitors (I)

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5613-5616

2009

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Structure activity relationships of quinoline-containing c-Met inhibitors

European journal of medicinal chemistry, 2008-06, Vol.43 (6), p.1321-1329

2008

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Phase 0 clinical trials: conceptions and misconceptions

The cancer journal (Sudbury, Mass.), 2008-05, Vol.14 (3), p.133-137

2008

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Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

Structure (London), 1999-03, Vol.7 (3), p.319-330

1999

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Identification and characterization of a novel and functional murine Pin1 isoform

Biochemical and biophysical research communications, 2007-08, Vol.359 (3), p.529-535

2007

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Characterization and Kinetic Mechanism of Catalytic Domain of Human Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase (VEGFR2 TK), a Key Enzyme in Angiogenesis

Biochemistry (Easton), 1998-11, Vol.37 (47), p.16788-16801

1998

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Identification of biologically active epidermal growth factor precursor in human fluids and secretions

Endocrinology (Philadelphia), 1993, Vol.132 (1), p.417-425

1993

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Expression of epidermal growth factor precursor cDNA in animal cells

Methods in Enzymology, 1991, Vol.198, p.175-185

Mroczkowski, Barbara

1991

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Secretion of thermostable DNA polymerase using a novel baculovirus vector

The Journal of biological chemistry, 1994-05, Vol.269 (18), p.13522-13528

1994

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Growth factors in the regenerating pancreas of gamma-interferon transgenic mice

Laboratory investigation, 1996-06, Vol.74 (6), p.985

1996

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Differentiation of HL-60 cells is associated with an increase in the 35-kDa protein lipocortin I

Journal of cellular physiology, 1988-12, Vol.137 (3), p.402-410

1988

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Expression of Human Epidermal Growth Factor Precursor cDNA in Transfected Mouse NIH 3T3 Cells

Proceedings of the National Academy of Sciences - PNAS, 1988-01, Vol.85 (1), p.126-130

1988

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THE CYTOPLASMIC UTILIZATION OF MUSCLE MESSENGER-RNA TRANSCRIPTS DURING MYOGENESIS

MROCZKOWSKI, BARBARA

1982

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Preparation and characterization of a bifunctionally spin-labeled mutant of murine epidermal growth factor for saturation-transfer electron paramagnetic resonance studies of the growth factor/receptor complex

Biochemistry (Easton), 1993-08, Vol.32 (31), p.7893-7903

1993

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Recombinant Human Epidermal Growth Factor Precursor Is a Glycosylated Membrane Protein with Biological Activity

Molecular and cellular biology, 1989-07, Vol.9 (7), p.2771-2778

1989

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Uptake and utilization of mRNA by myogenic cells in culture

The Journal of cell biology, 1980-10, Vol.87 (1), p.65-71

1980

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2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma

An orally available small-molecule inhibitor of c-met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms

Sulforaphane is Synergistic with CB‐5083and Inhibits Colony Formation of CB‐5083‐Resistant HCT116 Cells

Molecular Dynamics Simulations for Improving Crystal Quality and Illuminating the Function of Taspase1: A Therapeutic Target

Sulforaphane is Synergistic with CB‐5083 and Inhibits Colony Formation of CB‐5083‐Resistant HCT116 Cells

Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs

Using microgravity at the Inernational Space Station to lead to new therapeutics for Taspase1: a novel cancer target

Structure-based design of novel human Pin1 inhibitors (I)

Structure activity relationships of quinoline-containing c-Met inhibitors

Phase 0 clinical trials: conceptions and misconceptions

Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

Identification and characterization of a novel and functional murine Pin1 isoform

Characterization and Kinetic Mechanism of Catalytic Domain of Human Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase (VEGFR2 TK), a Key Enzyme in Angiogenesis

Identification of biologically active epidermal growth factor precursor in human fluids and secretions

Expression of epidermal growth factor precursor cDNA in animal cells

Secretion of thermostable DNA polymerase using a novel baculovirus vector

Growth factors in the regenerating pancreas of gamma-interferon transgenic mice

Differentiation of HL-60 cells is associated with an increase in the 35-kDa protein lipocortin I

Expression of Human Epidermal Growth Factor Precursor cDNA in Transfected Mouse NIH 3T3 Cells

THE CYTOPLASMIC UTILIZATION OF MUSCLE MESSENGER-RNA TRANSCRIPTS DURING MYOGENESIS

Preparation and characterization of a bifunctionally spin-labeled mutant of murine epidermal growth factor for saturation-transfer electron paramagnetic resonance studies of the growth factor/receptor complex

Recombinant Human Epidermal Growth Factor Precursor Is a Glycosylated Membrane Protein with Biological Activity

Uptake and utilization of mRNA by myogenic cells in culture

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