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Safety and immunogenicity of investigational recombinant botulinum vaccine, rBV A/B, in volunteers with pre-existing botulinum toxoid immunity

Vaccine, 2018-04, Vol.36 (15), p.2041-2048

2018

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Dual-Toxin (“Bivalent”) Infant Botulism in California, 1976-2020: Epidemiologic, Clinical, and Laboratory Aspects

The Journal of pediatrics, 2023-02, Vol.253, p.8-13

2023

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A Single Ascending Dose Study of Bapineuzumab in Patients With Alzheimer Disease

Alzheimer disease and associated disorders, 2010-04, Vol.24 (2), p.198-203

2010

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Partial Reduction of BACE1 Has Dramatic Effects on Alzheimer Plaque and Synaptic Pathology in APP Transgenic Mice

The Journal of biological chemistry, 2007-09, Vol.282 (36), p.26326-26334

2007

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Epitope and Isotype Specificities of Antibodies to β-Amyloid Peptide for Protection against Alzheimer's Disease-like Neuropathology

Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (4), p.2023-2028

2003

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Discovery of (R)‑4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro‑1H‑pyrazolo[4,3‑c]quinoline (ELND006) and (R)‑4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro‑2H‑pyrazolo[4,3‑c]quinoline (ELND007): Metabolically Stable γ‑Secretase Inhibitors that Selectively Inhibit the Production of Amyloid‑β over Notch

Journal of medicinal chemistry, 2013-07, Vol.56 (13), p.5261-5274

2013

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Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (9), p.2743-2749

2013

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Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (21), p.6231-6236

2010

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Distribution of Aβ peptide in whole blood

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007-02, Vol.846 (1), p.24-31

2007

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Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Nature medicine, 2000-08, Vol.6 (8), p.916-919

2000

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Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

The Journal of biological chemistry, 2009-01, Vol.284 (5), p.2598-2602

2009

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Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease

The Journal of neuroscience, 2005-10, Vol.25 (40), p.9096-9101

2005

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Nature (London), 1999-07, Vol.400 (6740), p.173-177

1999

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Development of an enzyme-linked immunosorbent assay (ELISA) to measure the level of tyrosine hydroxylase protein in brain tissue from Parkinson's disease models

Journal of neuroscience methods, 2013-05, Vol.215 (2), p.245-257

2013

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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (7), p.1974-1977

2013

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Discovery of ( R )-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1 H -pyrazolo[4,3- c ]quinoline (ELND006) and ( R )-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2 H -pyrazolo[4,3- c ]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

Journal of medicinal chemistry, 2013-07, Vol.56 (13), p.5261-5274

2013

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Nature medicine, 1997-01, Vol.3 (1), p.67-72

1997

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Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri ®) with endogenous IgG4

Journal of pharmaceutical and biomedical analysis, 2011-04, Vol.55 (1), p.168-175

2011

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Active beta-amyloid immunization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid

The Journal of neuroscience, 2007-03, Vol.27 (10), p.2654-2662

2007

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Antibody Capture of Soluble Aβ Does Not Reduce Cortical Aβ Amyloidosis in the PDAPP Mouse

Neuro-degenerative diseases, 2008-01, Vol.5 (2), p.65-71

2008

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Longitudinal stability of CSF tau levels in Alzheimer patients

Biological psychiatry (1969), 1999-09, Vol.46 (6), p.750-755

1999

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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

Alzheimer's research & therapy, 2010-12, Vol.2 (6), p.36-36, Article 36

2010

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Safety and immunogenicity of investigational recombinant botulinum vaccine, rBV A/B, in volunteers with pre-existing botulinum toxoid immunity

Dual-Toxin (“Bivalent”) Infant Botulism in California, 1976-2020: Epidemiologic, Clinical, and Laboratory Aspects

A Single Ascending Dose Study of Bapineuzumab in Patients With Alzheimer Disease

Partial Reduction of BACE1 Has Dramatic Effects on Alzheimer Plaque and Synaptic Pathology in APP Transgenic Mice

Epitope and Isotype Specificities of Antibodies to β-Amyloid Peptide for Protection against Alzheimer's Disease-like Neuropathology

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Distribution of Aβ peptide in whole blood

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

BACE knockout mice are healthy despite lacking the primary β-secretase activity in brain: implications for Alzheimer's disease therapeutics

Development of an enzyme-linked immunosorbent assay (ELISA) to measure the level of tyrosine hydroxylase protein in brain tissue from Parkinson's disease models

Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce [alpha]-Synuclein Phosphorylation in Rat Brain

Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri ®) with endogenous IgG4

Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce α-Synuclein Phosphorylation in Rat Brain

Active beta-amyloid immunization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid

Antibody Capture of Soluble Aβ Does Not Reduce Cortical Aβ Amyloidosis in the PDAPP Mouse

Longitudinal stability of CSF tau levels in Alzheimer patients

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

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