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Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14142-14152

2021

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Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of [ 14 C]aficamten following single oral dose administration to rats

Xenobiotica, 2024-08, p.1-16

2024

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Discovery of GBT440, an Orally Bioavailable R‑State Stabilizer of Sickle Cell Hemoglobin

ACS medicinal chemistry letters, 2017-03, Vol.8 (3), p.321-326

2017

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In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor

Xenobiotica, 2024-08, p.1-15

2024

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Cardiac myosin activation part 1: From concept to clinic

Journal of molecular and cellular cardiology, 2011-10, Vol.51 (4), p.454-461

2011

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Cardiac myosin inhibitor, CK-586, minimally reduces systolic function and ameliorates obstruction in feline hypertrophic cardiomyopathy

Scientific reports, 2024-05, Vol.14 (1), p.12038-12038, Article 12038

2024

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Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy

Scientific reports, 2023-01, Vol.13 (1), p.32-11, Article 32

2023

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Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats

Journal of medicinal chemistry, 2024-05, Vol.67 (10), p.7859-7869

2024

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Highly selective inhibition of myosin motors provides the basis of potential therapeutic application

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (47), p.E7448-E7455

2016

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Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility

Journal of medicinal chemistry, 2024-05, Vol.67 (10), p.7825-7835

2024

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Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function

Journal of medicinal chemistry, 2021-10, Vol.64 (20), p.14930-14941

2021

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Preclinical characterization of CK-4021586, a new class of cardiac myosin inhibitors for the treatment of hypertrophic cardiomyopathy

Biophysical journal, 2023-02, Vol.122 (3), p.122a-122a

2023

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Pharmacokinetics of a single dose of Aficamten (CK‐274) on cardiac contractility in a A31P MYBPC3 hypertrophic cardiomyopathy cat model

Journal of veterinary pharmacology and therapeutics, 2023-01, Vol.46 (1), p.52-61

2023

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Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases

Nature medicine, 2012-03, Vol.18 (3), p.452-455

2012

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Medical Malpractice Lawsuits Involving Pediatric Trainees

Curēus (Palo Alto, CA), 2023-08

2023

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Preventive interventions for children of parents with depression: international perspectives

Medical journal of Australia, 2013-08, Vol.199 (3 Suppl), p.S23-S25

2013

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Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

Science (American Association for the Advancement of Science), 2011-03, Vol.331 (6023), p.1439-1443

2011

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Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy

Nature Cardiovascular Research, 2024-08, Vol.3 (8), p.1003-1016

2024

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Preventive interventions for children of parents with depression: international perspectives. [Paper in special issue: Parental Mental Illness is a Family Matter. Reupert, Andrea E.; Maybery, Darryl J. and Kowalenko, Nicholas M. (eds)]

Medical journal of Australia open, 2013-01, Vol.1 (supp. 1), p.23-25

2013

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Flat epithelial atypia with and without atypical ductal hyperplasia: to re-excise or not. Results of a 5-year prospective study

Virchows Archiv : an international journal of pathology, 2012-10, Vol.461 (4), p.419-423

2012

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Development of a Factory Process for Omecamtiv Mecarbil, a Novel Cardiac Myosin Activator

Organic process research & development, 2019-08, Vol.23 (8), p.1558-1567

2019

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Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin

ACS medicinal chemistry letters, 2010-12, Vol.1 (9), p.472-477

2010

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Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator

ACS medicinal chemistry letters, 2018-04, Vol.9 (4), p.354-358

2018

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Abbott ARCHITECT STAT Contemporary Troponin I Outlier Detection and Prevention of Erroneous Outlier Result Reporting Using an Immediate Repeat Testing Protocol: A 1-Year Summary

American journal of clinical pathology, 2019-09, Vol.152 (Supplement_1), p.S80-S81

2019

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Supporting families of parents with mental illness in general practice

Medical journal of Australia, 2013-08, Vol.199 (3 Suppl), p.S11-S13

2013

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Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of [ 14 C]aficamten following single oral dose administration to rats

Discovery of GBT440, an Orally Bioavailable R‑State Stabilizer of Sickle Cell Hemoglobin

In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor

Cardiac myosin activation part 1: From concept to clinic

Cardiac myosin inhibitor, CK-586, minimally reduces systolic function and ameliorates obstruction in feline hypertrophic cardiomyopathy

Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy

Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats

Highly selective inhibition of myosin motors provides the basis of potential therapeutic application

Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility

Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function

Preclinical characterization of CK-4021586, a new class of cardiac myosin inhibitors for the treatment of hypertrophic cardiomyopathy

Pharmacokinetics of a single dose of Aficamten (CK‐274) on cardiac contractility in a A31P MYBPC3 hypertrophic cardiomyopathy cat model

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases

Medical Malpractice Lawsuits Involving Pediatric Trainees

Preventive interventions for children of parents with depression: international perspectives

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy

Preventive interventions for children of parents with depression: international perspectives. [Paper in special issue: Parental Mental Illness is a Family Matter. Reupert, Andrea E.; Maybery, Darryl J. and Kowalenko, Nicholas M. (eds)]

Flat epithelial atypia with and without atypical ductal hyperplasia: to re-excise or not. Results of a 5-year prospective study

Development of a Factory Process for Omecamtiv Mecarbil, a Novel Cardiac Myosin Activator

Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin

Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator

Abbott ARCHITECT STAT Contemporary Troponin I Outlier Detection and Prevention of Erroneous Outlier Result Reporting Using an Immediate Repeat Testing Protocol: A 1-Year Summary

Supporting families of parents with mental illness in general practice

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