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Niclosamide: Beyond an antihelminthic drug

Cellular signalling, 2018-01, Vol.41, p.89-96

2018

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Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy

Biochemical journal, 2019-02, Vol.476 (3), p.535-546

2019

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Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype

Bioorganic & medicinal chemistry letters, 2019-01, Vol.29 (2), p.317-321

2019

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In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1

Molecular cancer therapeutics, 2007-02, Vol.6 (2), p.450-459

2007

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Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements

Journal of proteome research, 2016-08, Vol.15 (8), p.2688-2696

2016

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Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4632-4640

2008

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Structure–activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure

Bioorganic & medicinal chemistry, 2015-09, Vol.23 (17), p.5829-5838

2015

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Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain

Scientific reports, 2016-06, Vol.6 (1), p.26894-26894, Article 26894

2016

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Small molecule modulators of Wnt/β-catenin signaling

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (7), p.2187-2191

2013

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Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (17), p.4686-4691

2006

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Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth

Bioorganic & medicinal chemistry, 2018-11, Vol.26 (20), p.5435-5442

2018

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Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B‑Raf-Driven Tumors

ACS medicinal chemistry letters, 2013-03, Vol.4 (3), p.358-362

2013

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The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks

Toxicological sciences, 2012-08, Vol.128 (2), p.517-523

2012

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Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling

Bioorganic & medicinal chemistry, 2012-11, Vol.20 (22), p.6751-6757

2012

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Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis

Bioorganic & medicinal chemistry, 2017-03, Vol.25 (6), p.1804-1816

2017

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Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth

Breast cancer research : BCR, 2015-02, Vol.17 (1), p.20-20, Article 20

2015

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Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.360-364

2009

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Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition

Journal of medicinal chemistry, 2015-10, Vol.58 (19), p.7659-7671

2015

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Discovery of thiophene inhibitors of polo-like kinase

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.1018-1021

2009

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Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.469-473

2009

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Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth

Nanoscale, 2017-08, Vol.9 (34), p.12709-12717

2017

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Discovery and optimization of imidazo[1,2- a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R)

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.1004-1008

2009

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Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1694-1697

2009

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Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (15), p.4436-4440

2011

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Glucocorticoid Hedgehog Agonists in Neurogenesis

Stem Cell Regulators, 2011, Vol.87, p.207-215

2011

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Niclosamide: Beyond an antihelminthic drug

Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy

Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype

In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1

Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements

Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor

Structure–activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure

Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain

Small molecule modulators of Wnt/β-catenin signaling

Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series

Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B‑Raf-Driven Tumors

The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks

Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling

Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis

Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth

Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition

Discovery of thiophene inhibitors of polo-like kinase

Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase

Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth

Discovery and optimization of imidazo[1,2- a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R)

Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding

Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup

Glucocorticoid Hedgehog Agonists in Neurogenesis

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