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Antisense therapy for cancer

Nature reviews. Cancer, 2005-06, Vol.5 (6), p.468-479

2005

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients

Cancer cell, 2004-08, Vol.6 (2), p.117-127

2004

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miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

Cell metabolism, 2006-02, Vol.3 (2), p.87-98

2006

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In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis

International journal of molecular sciences, 2021-08, Vol.22 (17), p.9488

2021

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Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

The Journal of clinical investigation, 2006-03, Vol.116 (3), p.817-824

2006

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Mcl-1 overexpression in hepatocellular carcinoma: A potential target for antisense therapy

Journal of hepatology, 2006-01, Vol.44 (1), p.151-157

2006

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Role of resistin in diet-induced hepatic insulin resistance

The Journal of clinical investigation, 2004-07, Vol.114 (2), p.232-239

2004

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Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

Hepatology (Baltimore, Md.), 2005-08, Vol.42 (2), p.362-371

2005

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Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides

Blood, 2005-04, Vol.105 (8), p.3303-3311

2005

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Reduction in Glucagon Receptor Expression by an Antisense Oligonucleotide Ameliorates Diabetic Syndrome in db/db Mice

Diabetes (New York, N.Y.), 2004-02, Vol.53 (2), p.410-417

2004

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Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells

Cancer research (Chicago, Ill.), 2001-10, Vol.61 (19), p.7079-7090

2001

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Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice

Diabetes (New York, N.Y.), 2002-04, Vol.51 (4), p.1028-1034

2002

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Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

The Journal of clinical investigation, 2004-06, Vol.113 (11), p.1571-1581

2004

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Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C- raf kinase

Nature medicine, 1996-06, Vol.2 (6), p.668-675

1996

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Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism

Diabetes (New York, N.Y.), 2005-06, Vol.54 (6), p.1846-1853

2005

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Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis

Diabetes (New York, N.Y.), 2002-08, Vol.51 (8), p.2405-2411

2002

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Inhibition of hepatic endothelial E-selectin expression by C-raf antisense oligonucleotides blocks colorectal carcinoma liver metastasis

Cancer research (Chicago, Ill.), 2002-10, Vol.62 (19), p.5393-5398

2002

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Platelet-Localized FXI Promotes a Glycoprotein Ib Alpha Dependent Feedback Loop in Arterial Hypertension and Vascular Inflammation

BLOOD, 2015-12, Vol.126 (23), p.2192-2192

2015

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Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2'-O-(2-methoxy)ethyl chemistry

The Journal of pharmacology and experimental therapeutics, 2001-09, Vol.298 (3), p.934

2001

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Inotersen Improves Quality of Life and Neuropathy in Patients with Hereditary Transthyretin (HATTR) Amyloidosis with Polyneuropathy: Results of the Phase 3 Study Neuro-TTR

Value in health, 2018-05, Vol.21, p.S202

2018

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PND3 - Inotersen Improves Quality of Life and Neuropathy in Patients with Hereditary Transthyretin (HATTR) Amyloidosis with Polyneuropathy: Results of the Phase 3 Study Neuro-TTR

Value in health, 2018-05, Vol.21, p.S202-S202

2018

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Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect

Molecular cancer therapeutics, 2004-02, Vol.3 (2), p.169-178

2004

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Mcl-1 Antisense Therapy Chemosensitizes Human Melanoma in a SCID Mouse Xenotransplantation Model

Journal of investigative dermatology, 2003-06, Vol.120 (6), p.1081-1086

2003

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Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression

The Journal of biological chemistry, 1993-07, Vol.268 (19), p.14514-14522

1993

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Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway

Endocrinology (Philadelphia), 2001-08, Vol.142 (8), p.3405-3413

2001

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Antisense therapy for cancer

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

Mcl-1 overexpression in hepatocellular carcinoma: A potential target for antisense therapy

Role of resistin in diet-induced hepatic insulin resistance

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides

Reduction in Glucagon Receptor Expression by an Antisense Oligonucleotide Ameliorates Diabetic Syndrome in db/db Mice

Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells

Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice

Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C- raf kinase

Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism

Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis

Inhibition of hepatic endothelial E-selectin expression by C-raf antisense oligonucleotides blocks colorectal carcinoma liver metastasis

Platelet-Localized FXI Promotes a Glycoprotein Ib Alpha Dependent Feedback Loop in Arterial Hypertension and Vascular Inflammation

Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2'-O-(2-methoxy)ethyl chemistry

Inotersen Improves Quality of Life and Neuropathy in Patients with Hereditary Transthyretin (HATTR) Amyloidosis with Polyneuropathy: Results of the Phase 3 Study Neuro-TTR

PND3 - Inotersen Improves Quality of Life and Neuropathy in Patients with Hereditary Transthyretin (HATTR) Amyloidosis with Polyneuropathy: Results of the Phase 3 Study Neuro-TTR

Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect

Mcl-1 Antisense Therapy Chemosensitizes Human Melanoma in a SCID Mouse Xenotransplantation Model

Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression

Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway

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