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APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells

Cell death & disease, 2015-06, Vol.6 (6), p.e1794-e1794

2015

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The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine

Psychopharmacologia, 2004-12, Vol.177 (1-2), p.207-216

2004

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Carbon-11-FLB 457: A Radioligand for Extrastriatal D2 Dopamine Receptors

The Journal of nuclear medicine (1978), 1995-07, Vol.36 (7), p.1275-1281

1995

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Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors

Molecular pharmacology, 1993-05, Vol.43 (5), p.749-754

1993

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Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer

Journal of ovarian research, 2016-05, Vol.9 (1), p.27, Article 27

2016

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The beta-adrenergic radioligand [3H]CGP-12177, generally classified as an antagonist, is a thermogenic agonist in brown adipose tissue

Biochemical journal, 1989-07, Vol.261 (2), p.401-405

1989

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Neuropeptide Y‐family receptors Y 6 and Y 7 in chicken: Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region

The FEBS journal, 2006-05, Vol.273 (9), p.2048-2063

2006

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Molecular basis for the binding of 2-aminotetralins to human dopamine D2A and D3 receptors

Molecular pharmacology, 1994-08, Vol.46 (2), p.299

1994

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Thermogenesis in brown adipocytes is inhibited by volatile anesthetic agents. A factor contributing to hypothermia in infants?

Anesthesiology (Philadelphia), 1994-07, Vol.81 (1), p.176-183

1994

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APR-246, a new class anticancer compound in phase l/lla clinical trials

Journal of clinical oncology, 2010-05, Vol.28 (15_suppl), p.TPS183-TPS183

2010

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Novel 2-Aminotetralin and 3-AminoChroman Derivatives as Selective Serotonin 5-HT7 Receptor Agonists and Antagonists

Journal of medicinal chemistry, 2004-07, Vol.47 (16), p.3927-3930

2004

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Characterization of [3H]quinpirole binding to human dopamine D2A and D3 receptors: effects of ions and guanine nucleotides

The Journal of pharmacology and experimental therapeutics, 1995-08, Vol.274 (2), p.790

1995

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Re-evaluation of receptor-ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study

Biochemical journal, 2006-01, Vol.393 (Pt 1), p.161-169

2006

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Preclinical findings with new antipsychotic agents: what makes them atypical?

Acta psychiatrica Scandinavica, 1994-01, Vol.89 (s380), p.41-48

1994

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Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

Journal of medicinal chemistry, 2002-11, Vol.45 (23), p.4950-4953

2002

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APR-246, a clinical-stage mutant p53-reactivating compound, resensitizes ovarian cancer cells to platinum compounds and doxorubicin

CANCER RESEARCH, 2014, Vol.74 (19)

2014

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Design, Synthesis and Evaluation of a PLG Tripeptidomimetic Based on a Pyridine Scaffold

Journal of medicinal chemistry, 2004-12, Vol.47 (26), p.6595-6602

2004

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Cold acclimation induces desensitization to adenosine in brown fat cells without changing receptor binding

American Journal of Physiology: Cell Physiology, 1990-05, Vol.258 (5), p.C818-C826

1990

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Physiological desensitization of beta 3-adrenergic responses in brown fat cells: involvement of a postreceptor process

American Journal of Physiology: Cell Physiology, 1993-11, Vol.265 (5), p.C1340-C1348

1993

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Inhibitory effects of halothane on the thermogenic pathway in brown adipocytes: localization to adenylyl cyclase and mitochondrial fatty acid oxidation

Biochemical pharmacology, 2004-08, Vol.68 (3), p.463-477

2004

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Pharmacology of polymorphic variants of the human 5-HT1A receptor

Biochemical pharmacology, 2004-02, Vol.67 (3), p.479-490

2004

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Alpha 1-adrenergic receptors in brown adipose tissue. Thermogenic significance and mode of action

Acta physiologica Scandinavica. Supplementum, 1984, Vol.530, p.1

Mohell, N

1984

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Agonist and inverse agonist activity at the dopamine D3 receptor measured by guanosine 5'--gamma-thio-triphosphate--35S- binding

The Journal of pharmacology and experimental therapeutics, 1998-04, Vol.285 (1), p.119

1998

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Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives

Bioorganic & medicinal chemistry letters, 2001-02, Vol.11 (3), p.367-370

2001

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Re-evaluation of receptor–ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study

Biochemical journal, 2006-09, Vol.398 (3), p.613-613

2006

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APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells

The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine

Carbon-11-FLB 457: A Radioligand for Extrastriatal D2 Dopamine Receptors

Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors

Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer

The beta-adrenergic radioligand [3H]CGP-12177, generally classified as an antagonist, is a thermogenic agonist in brown adipose tissue

Neuropeptide Y‐family receptors Y 6 and Y 7 in chicken: Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region

Molecular basis for the binding of 2-aminotetralins to human dopamine D2A and D3 receptors

Thermogenesis in brown adipocytes is inhibited by volatile anesthetic agents. A factor contributing to hypothermia in infants?

APR-246, a new class anticancer compound in phase l/lla clinical trials

Novel 2-Aminotetralin and 3-AminoChroman Derivatives as Selective Serotonin 5-HT7 Receptor Agonists and Antagonists

Characterization of [3H]quinpirole binding to human dopamine D2A and D3 receptors: effects of ions and guanine nucleotides

Re-evaluation of receptor-ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study

Preclinical findings with new antipsychotic agents: what makes them atypical?

Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

APR-246, a clinical-stage mutant p53-reactivating compound, resensitizes ovarian cancer cells to platinum compounds and doxorubicin

Design, Synthesis and Evaluation of a PLG Tripeptidomimetic Based on a Pyridine Scaffold

Cold acclimation induces desensitization to adenosine in brown fat cells without changing receptor binding

Physiological desensitization of beta 3-adrenergic responses in brown fat cells: involvement of a postreceptor process

Inhibitory effects of halothane on the thermogenic pathway in brown adipocytes: localization to adenylyl cyclase and mitochondrial fatty acid oxidation

Pharmacology of polymorphic variants of the human 5-HT1A receptor

Alpha 1-adrenergic receptors in brown adipose tissue. Thermogenic significance and mode of action

Agonist and inverse agonist activity at the dopamine D3 receptor measured by guanosine 5'--gamma-thio-triphosphate--35S- binding

Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives

Re-evaluation of receptor–ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study

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