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A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015

Current medicinal chemistry, 2017-09, Vol.24 (29), p.3159

2017

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Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

Drug metabolism letters, 2016-06, Vol.10 (2), p.83-90

2016

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Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models

PloS one, 2013-08, Vol.8 (8), p.e71754

2013

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Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.360-365

2013

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Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.18193-18208

2021

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Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation

Drug metabolism letters, 2016-06, Vol.10 (2), p.144-150

2016

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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.8989-9002

2017

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CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization

Molecular cancer therapeutics, 2015-06, Vol.14 (6), p.1295-1305

2015

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Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223

Journal of medicinal chemistry, 2015-07, Vol.58 (13), p.5323-5333

2015

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Implementation of a novel ultra fast metabolic stability analysis method using exact mass TOF-MS

Bioanalysis, 2017-02, Vol.9 (4), p.359-368

2017

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Proposing advancement criteria for efficient DMPK triage of new chemical entities

Future medicinal chemistry, 2014-02, Vol.6 (2), p.131-139

2014

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A Proposed Screening Paradigm for Discovery of Covalent Inhibitor Drugs

Drug metabolism letters, 2014-06, Vol.8 (1), p.19-30

2014

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Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase

Nature medicine, 1997-05, Vol.3 (5), p.562-566

1997

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Biotransformation, excretion kinetics, and tissue distribution of an N-pyrrolo[1,2-c]imidazolylphenyl sulfonamide herbicide in rats

Drug metabolism and disposition, 2001-08, Vol.29 (8), p.1162

2001

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Cell-Free Biosynthesis and Source of Hydroxyl Groups in (12R, 13S)-Dihydroxy-(5Z,8Z, 10E, 14Z)-Eicosatetraenoic Acid, a Novel Eicosanoid from the Marine Alga Gracilariopsis lemaneiformis

Journal of natural products (Washington, D.C.), 1991-11, Vol.54 (6), p.1619-1624

1991

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An LC/MS/MS Method for Improved Quantitation of the Bound Residues in the Tissues of Animals Orally Dosed with [14C]Benomyl

Journal of agricultural and food chemistry, 2000-11, Vol.48 (11), p.5195-5199

2000

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Plasma pharmacokinetics and tissue distribution of a N-pyrrolo-[1,2-c]imidazolylphenyl sulfonamide in rats

Drug metabolism and disposition, 2002-01, Vol.30 (1), p.47-54

2002

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A proposed screening paradigm for discovery of covalent inhibitor drugs

Drug metabolism letters, 2014, Vol.8 (1), p.19

2014

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Gloiosiphones A and B, Novel Metabolites from the Red Marine Alga Gloiosiphonia verticillaris

Journal of natural products (Washington, D.C.), 1993-08, Vol.56 (8), p.1205-1210

1993

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Metabolite Profiling and Structural Identification

Preclinical Development Handbook, 2008, p.937-974

2008

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Application of 1D and 2D 1H-NMR in the structural elucidation of a N-glucuronidated metabolite and oxidized metabolites generated in microsomal incubation

Drug metabolism letters, 2012, Vol.6 (4), p.265

2012

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Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models. e71754

PloS one, 2013-08, Vol.8 (8)

2013

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Novel metabolic pathways for linoleic and arachidonic acid metabolism

Biochimica et biophysica acta, 1996-08, Vol.1290 (3), p.327-339

1996

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Metabolite Interference in Pharmacokinetic Studies

Drug metabolism letters, 2007-12, Vol.1 (4), p.272-275

2007

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A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015

Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001

Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen

Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115

CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization

Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223

Implementation of a novel ultra fast metabolic stability analysis method using exact mass TOF-MS

Proposing advancement criteria for efficient DMPK triage of new chemical entities

A Proposed Screening Paradigm for Discovery of Covalent Inhibitor Drugs

Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase

Biotransformation, excretion kinetics, and tissue distribution of an N-pyrrolo[1,2-c]imidazolylphenyl sulfonamide herbicide in rats

Cell-Free Biosynthesis and Source of Hydroxyl Groups in (12R, 13S)-Dihydroxy-(5Z,8Z, 10E, 14Z)-Eicosatetraenoic Acid, a Novel Eicosanoid from the Marine Alga Gracilariopsis lemaneiformis

An LC/MS/MS Method for Improved Quantitation of the Bound Residues in the Tissues of Animals Orally Dosed with [14C]Benomyl

Plasma pharmacokinetics and tissue distribution of a N-pyrrolo-[1,2-c]imidazolylphenyl sulfonamide in rats

A proposed screening paradigm for discovery of covalent inhibitor drugs

Gloiosiphones A and B, Novel Metabolites from the Red Marine Alga Gloiosiphonia verticillaris

Metabolite Profiling and Structural Identification

Application of 1D and 2D 1H-NMR in the structural elucidation of a N-glucuronidated metabolite and oxidized metabolites generated in microsomal incubation

Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models. e71754

Novel metabolic pathways for linoleic and arachidonic acid metabolism

Metabolite Interference in Pharmacokinetic Studies

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