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A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015

Current medicinal chemistry, 2017-09, Vol.24 (29), p.3159

2017

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Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

Drug metabolism letters, 2016-06, Vol.10 (2), p.83

2016

Volltextzugriff (PDF)

Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models

PloS one, 2013-08, Vol.8 (8), p.e71754

2013

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Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.360-365

2013

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Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation

Drug metabolism letters, 2016-06, Vol.10 (2), p.144

2016

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Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.18193-18208

2021

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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.8989-9002

2017

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CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization

Molecular cancer therapeutics, 2015-06, Vol.14 (6), p.1295-1305

2015

Volltextzugriff (PDF)

Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223

Journal of medicinal chemistry, 2015-07, Vol.58 (13), p.5323-5333

2015

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Implementation of a novel ultra fast metabolic stability analysis method using exact mass TOF-MS

Bioanalysis, 2017-02, Vol.9 (4), p.359-368

2017

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Proposing advancement criteria for efficient DMPK triage of new chemical entities

Future medicinal chemistry, 2014-02, Vol.6 (2), p.131-139

2014

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Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase

Nature medicine, 1997-05, Vol.3 (5), p.562-566

1997

Volltextzugriff (PDF)

Biotransformation, excretion kinetics, and tissue distribution of an N-pyrrolo[1,2-c]imidazolylphenyl sulfonamide herbicide in rats

Drug metabolism and disposition, 2001-08, Vol.29 (8), p.1162

2001

Volltextzugriff (PDF)

Cell-Free Biosynthesis and Source of Hydroxyl Groups in (12R, 13S)-Dihydroxy-(5Z,8Z, 10E, 14Z)-Eicosatetraenoic Acid, a Novel Eicosanoid from the Marine Alga Gracilariopsis lemaneiformis

Journal of natural products (Washington, D.C.), 1991-11, Vol.54 (6), p.1619-1624

1991

Volltextzugriff (PDF)

Plasma pharmacokinetics and tissue distribution of a N-pyrrolo-[1,2-c]imidazolylphenyl sulfonamide in rats

Drug metabolism and disposition, 2002-01, Vol.30 (1), p.47

2002

Volltextzugriff (PDF)

A proposed screening paradigm for discovery of covalent inhibitor drugs

Drug metabolism letters, 2014, Vol.8 (1), p.19

2014

Volltextzugriff (PDF)

Gloiosiphones A and B, Novel Metabolites from the Red Marine Alga Gloiosiphonia verticillaris

Journal of natural products (Washington, D.C.), 1993-08, Vol.56 (8), p.1205-1210

1993

Volltextzugriff (PDF)

Application of 1D and 2D 1H-NMR in the structural elucidation of a N-glucuronidated metabolite and oxidized metabolites generated in microsomal incubation

Drug metabolism letters, 2012, Vol.6 (4), p.265

2012

Volltextzugriff (PDF)

Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models. e71754

PloS one, 2013-08, Vol.8 (8)

2013

Volltextzugriff (PDF)

Novel metabolic pathways for linoleic and arachidonic acid metabolism

Biochimica et biophysica acta, 1996-08, Vol.1290 (3), p.327-339

1996

Volltextzugriff (PDF)

Metabolite interference in pharmacokinetic studies

Drug metabolism letters, 2007-12, Vol.1 (4), p.272

2007

Volltextzugriff (PDF)

Development of an in situ toxicity assay system using recombinant baculoviruses

Biochemical pharmacology, 1996-02, Vol.51 (4), p.503-515

1996

Volltextzugriff (PDF)

Properties of enzymes hydrating epoxides in human epidermis and liver

International journal of biochemistry, 1993-09, Vol.25 (9), p.1291-1301

1993

Volltextzugriff (PDF)

Frequency of Paraoxonase 192/55 Polymorphism in an Iranian Population

Journal of Toxicology and Environmental Health, Part A, 2007-01, Vol.70 (13), p.1125-1129

2007

Volltextzugriff (PDF)

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A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015

Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation

Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen

Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115

CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization

Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223

Implementation of a novel ultra fast metabolic stability analysis method using exact mass TOF-MS

Proposing advancement criteria for efficient DMPK triage of new chemical entities

Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase

Biotransformation, excretion kinetics, and tissue distribution of an N-pyrrolo[1,2-c]imidazolylphenyl sulfonamide herbicide in rats

Cell-Free Biosynthesis and Source of Hydroxyl Groups in (12R, 13S)-Dihydroxy-(5Z,8Z, 10E, 14Z)-Eicosatetraenoic Acid, a Novel Eicosanoid from the Marine Alga Gracilariopsis lemaneiformis

Plasma pharmacokinetics and tissue distribution of a N-pyrrolo-[1,2-c]imidazolylphenyl sulfonamide in rats

A proposed screening paradigm for discovery of covalent inhibitor drugs

Gloiosiphones A and B, Novel Metabolites from the Red Marine Alga Gloiosiphonia verticillaris

Application of 1D and 2D 1H-NMR in the structural elucidation of a N-glucuronidated metabolite and oxidized metabolites generated in microsomal incubation

Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models. e71754

Novel metabolic pathways for linoleic and arachidonic acid metabolism

Metabolite interference in pharmacokinetic studies

Development of an in situ toxicity assay system using recombinant baculoviruses

Properties of enzymes hydrating epoxides in human epidermis and liver

Frequency of Paraoxonase 192/55 Polymorphism in an Iranian Population

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