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Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

The Journal of cell biology, 2014-01, Vol.204 (2), p.247-263

2014

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Necdin, a Prader–Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development

Human molecular genetics, 2009-01, Vol.18 (2), p.248-260

2009

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Rgnef promotes ovarian tumor progression and confers protection from oxidative stress

Oncogene, 2019-09, Vol.38 (36), p.6323-6337

2019

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FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth

Breast cancer research : BCR, 2015-03, Vol.17 (1), p.47-47, Article 47

2015

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Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression

The Journal of cell biology, 2012-06, Vol.197 (7), p.907-919

2012

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Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

Clinical & experimental metastasis, 2013-06, Vol.30 (5), p.579-594

2013

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Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

The Journal of biological chemistry, 2010-07, Vol.285 (28), p.21526-21536

2010

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Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6

The Journal of neuroscience, 2011-01, Vol.31 (2), p.426-438

2011

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Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer

Gynecologic oncology, 2014-07, Vol.134 (1), p.104-111

2014

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Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins

PloS one, 2012-05, Vol.7 (5), p.e37830-e37830

2012

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FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth

Molecular cancer therapeutics, 2014-08, Vol.13 (8), p.2050-2061

2014

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Enhancers of GnRH Transcription Embedded in an Upstream Gene Use Homeodomain Proteins to Specify Hypothalamic Expression

Molecular endocrinology (Baltimore, Md.), 2010-10, Vol.24 (10), p.1949-1964

2010

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p190RhoGEF (Rgnef) Promotes Colon Carcinoma Tumor Progression via Interaction with Focal Adhesion Kinase

Cancer research (Chicago, Ill.), 2011-01, Vol.71 (2), p.360-370

2011

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Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

Journal of medicinal chemistry, 2021-07, Vol.64 (13), p.9056-9077

2021

Volltextzugriff (PDF)

Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells

The Journal of biological chemistry, 2015-06, Vol.290 (24), p.15197-15209

2015

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A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation

Journal of cell science, 2013-11, Vol.126 (Pt 21), p.5074-5085

2013

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The Groucho-related Gene Family Regulates the Gonadotropin-releasing Hormone Gene through Interaction with the Homeodomain Proteins MSX1 and OCT1

The Journal of biological chemistry, 2005-09, Vol.280 (35), p.30975-30983

2005

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Phylogenetic Footprinting Reveals Evolutionarily Conserved Regions of the Gonadotropin-Releasing Hormone Gene that Enhance Cell-Specific Expression

Molecular endocrinology (Baltimore, Md.), 2004-12, Vol.18 (12), p.2950-2966

2004

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Antitumor activity of KIN-2787, a next-generation pan-RAF inhibitor, in combination with MEK inhibition in preclinical models of human NRAS mutant melanoma

Journal of clinical oncology, 2022-06, Vol.40 (16_suppl), p.e15099-e15099

2022

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The next-generation pan-RAF inhibitor, KIN-2787, is active in class II and class III BRAF mutant models

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.3116-3116

2021

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Durability of Kinase-Directed Therapies--A Network Perspective on Response and Resistance

Molecular cancer therapeutics, 2015-09, Vol.14 (9), p.1975-1984

2015

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Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity

Cell, 2023-06, Vol.186 (12), p.2628-2643.e21

2023

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Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor

Cancer cell, 2021-10, Vol.39 (10), p.1404-1421.e11

2021

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Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

Necdin, a Prader–Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development

Rgnef promotes ovarian tumor progression and confers protection from oxidative stress

FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression

Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6

Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer

Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins

FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

Enhancers of GnRH Transcription Embedded in an Upstream Gene Use Homeodomain Proteins to Specify Hypothalamic Expression

p190RhoGEF (Rgnef) Promotes Colon Carcinoma Tumor Progression via Interaction with Focal Adhesion Kinase

Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells

A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation

Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

The Groucho-related Gene Family Regulates the Gonadotropin-releasing Hormone Gene through Interaction with the Homeodomain Proteins MSX1 and OCT1

Phylogenetic Footprinting Reveals Evolutionarily Conserved Regions of the Gonadotropin-Releasing Hormone Gene that Enhance Cell-Specific Expression

Antitumor activity of KIN-2787, a next-generation pan-RAF inhibitor, in combination with MEK inhibition in preclinical models of human NRAS mutant melanoma

The next-generation pan-RAF inhibitor, KIN-2787, is active in class II and class III BRAF mutant models

Durability of Kinase-Directed Therapies--A Network Perspective on Response and Resistance

Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity

Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor

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