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SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer

Oncogene, 2020-12, Vol.39 (49), p.7166-7180

2020

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Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

Nature communications, 2019-01, Vol.10 (1), p.224-224, Article 224

2019

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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors

Nature communications, 2021-11, Vol.12 (1), p.6274-6274, Article 6274

2021

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Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity

Molecules (Basel, Switzerland), 2023-10, Vol.28 (19), p.6947

2023

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Recent Advances in First-Row-Transition-Metal-Catalyzed Dehydrogenative Coupling of C(sp3)-H Bonds

European journal of organic chemistry, 2015-12, Vol.2015 (36), p.7859-7868

2015

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Palladium-Catalyzed Chemoselective Decarboxylative Ortho Acylation of Benzoic Acids with α‑Oxocarboxylic Acids

Organic letters, 2013-06, Vol.15 (12), p.2930-2933

2013

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Palladium-Catalyzed Decarboxylative Cross-Coupling of α-Oxocarboxylic Acids and Their Derivatives

Synlett, 2014-04, Vol.25 (7), p.911-919

2014

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Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp3)–H Bonds

Organic letters, 2015-08, Vol.17 (15), p.3738-3741

2015

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Copper-Catalyzed Aerobic Dehydrogenative Cyclization of N-Methyl-N-phenylhydrazones: Synthesis of Cinnolines

Angewandte Chemie (International ed.), 2012-08, Vol.51 (33), p.8318-8321

International ed. in English, 2012

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Recent Advances in First-Row-Transition-Metal-Catalyzed Dehydrogenative Coupling of C(sp3)-H Bonds (Eur. J. Org. Chem. 36/2015)

European journal of organic chemistry, 2015-12, Vol.2015 (36), p.n/a

2015

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Copper-promoted site-selective carbonylation of sp3 and sp2 C-H bonds with nitromethane

Chemical science (Cambridge), 2016-08, Vol.7 (8), p.5260-5264

2016

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Mutations in the Gene Encoding Cystatin B in Progressive Myoclonus Epilepsy (EPM1)

Science (American Association for the Advancement of Science), 1996-03, Vol.271 (5256), p.1731-1734

1996

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Drugging Protein Tyrosine Phosphatases through Targeted Protein Degradation

ChemMedChem, 2024-04, Vol.19 (7), p.e202300669-e202300669

2024

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Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers

The Journal of clinical investigation, 2024-08, Vol.134 (15), p.1-15

2024

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Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

Neuron (Cambridge, Mass.), 2023-01, Vol.111 (2), p.236-255.e7

2023

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Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T‐Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy

Angewandte Chemie International Edition, 2023-05, Vol.62 (22), p.e202303818-n/a

International ed. in English, 2023

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Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases

Journal of medicinal chemistry, 2024-05, Vol.67 (11), p.8817-8835

2024

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Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides

Chemical communications (Cambridge, England), 2014-09, Vol.50 (68), p.9687-9689

2014

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Unstable minisatellite expansion causing recessively inherited myoclonus epilepsy, EPM1

Nature genetics, 1997-04, Vol.15 (4), p.393-396

1997

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Discovery of a selective TC-PTP degrader for cancer immunotherapy

Chemical science (Cambridge), 2023-11, Vol.14 (44), p.1266-12614

2023

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Copper-promoted site-selective carbonylation of sp 3 and sp 2 C-H bonds with nitromethane

Chemical science (Cambridge), 2016-08, Vol.7 (8), p.5260-5264

2016

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Copper-promoted site-selective carbonylation of sp3 and sp2 C-H bonds with nitromethaneElectronic supplementary information (ESI) available: Experimental procedures and characterization data. See DOI: 10.1039/c6sc01087c

2016-07

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Copper-promoted site-selective carbonylation of sp3 and sp2 C–H bonds with nitromethane† †Electronic supplementary information (ESI) available: Experimental procedures and characterization data. See DOI: 10.1039/c6sc01087c

Chemical science (Cambridge), 2016-04, Vol.7 (8), p.5260-5264

2016

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SHP2 phosphatase as a novel therapeutic target for melanoma treatment

Oncotarget, 2016-11, Vol.7 (45), p.73817-73829

2016

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PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371

Blood, 2023-01, Vol.141 (3), p.244-259

2023

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SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors

Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity

Recent Advances in First-Row-Transition-Metal-Catalyzed Dehydrogenative Coupling of C(sp3)-H Bonds

Palladium-Catalyzed Chemoselective Decarboxylative Ortho Acylation of Benzoic Acids with α‑Oxocarboxylic Acids

Palladium-Catalyzed Decarboxylative Cross-Coupling of α-Oxocarboxylic Acids and Their Derivatives

Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp3)–H Bonds

Copper-Catalyzed Aerobic Dehydrogenative Cyclization of N-Methyl-N-phenylhydrazones: Synthesis of Cinnolines

Recent Advances in First-Row-Transition-Metal-Catalyzed Dehydrogenative Coupling of C(sp3)-H Bonds (Eur. J. Org. Chem. 36/2015)

Copper-promoted site-selective carbonylation of sp3 and sp2 C-H bonds with nitromethane

Mutations in the Gene Encoding Cystatin B in Progressive Myoclonus Epilepsy (EPM1)

Drugging Protein Tyrosine Phosphatases through Targeted Protein Degradation

Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T‐Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy

Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases

Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides

Unstable minisatellite expansion causing recessively inherited myoclonus epilepsy, EPM1

Discovery of a selective TC-PTP degrader for cancer immunotherapy

Copper-promoted site-selective carbonylation of sp 3 and sp 2 C-H bonds with nitromethane

Copper-promoted site-selective carbonylation of sp3 and sp2 C-H bonds with nitromethaneElectronic supplementary information (ESI) available: Experimental procedures and characterization data. See DOI: 10.1039/c6sc01087c

Copper-promoted site-selective carbonylation of sp3 and sp2 C–H bonds with nitromethane† †Electronic supplementary information (ESI) available: Experimental procedures and characterization data. See DOI: 10.1039/c6sc01087c

SHP2 phosphatase as a novel therapeutic target for melanoma treatment

PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371

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