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Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation

Investigative ophthalmology & visual science, 2014-09, Vol.55 (10), p.6525-6534

2014

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The Discovery of N‑(1-Methyl-5-(trifluoromethyl)‑1H‑pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)‑1H‑indole-1-carboxamide (Acrizanib), a VEGFR‑2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

Journal of medicinal chemistry, 2018-02, Vol.61 (4), p.1622-1635

2018

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Discovery of Oral VEGFR‑2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

Journal of medicinal chemistry, 2015-12, Vol.58 (23), p.9273-9286

2015

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Scaffold Morphing Identifies 3‑Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT)

ACS medicinal chemistry letters, 2019-11, Vol.10 (11), p.1524-1529

2019

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Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates

ACS medicinal chemistry letters, 2018-08, Vol.9 (8), p.838-842

2018

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Total Synthesis of (+)-Geldanamycin and (−)-o-Quinogeldanamycin: Asymmetric Glycolate Aldol Reactions and Biological Evaluation

Journal of organic chemistry, 2003-10, Vol.68 (21), p.8162-8169

2003

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Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors

Journal of medicinal chemistry, 2010-08, Vol.53 (15), p.5400-5421

2010

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Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

ACS medicinal chemistry letters, 2013-12, Vol.4 (12), p.1203-1207

2013

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Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D

Journal of medicinal chemistry, 2010-08, Vol.53 (15), p.5422-5438

2010

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Lack of involvement of CEP adducts in TLR activation and in angiogenesis

PloS one, 2014-10, Vol.9 (10), p.e111472-e111472

2014

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Total Synthesis of (+)-Geldanamycin and (−)-o-Quinogeldanamycin with Use of Asymmetric Anti- and Syn-Glycolate Aldol Reactions

Organic letters, 2002-10, Vol.4 (20), p.3549-3552

2002

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Selective Synthesis of the para-Quinone Region of Geldanamycin

Organic letters, 2003-10, Vol.5 (21), p.3859-3862

2003

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Synthesis of resveratrol using a direct decarbonylative Heck approach from resorcylic acid

Tetrahedron letters, 2003-06, Vol.44 (26), p.4819-4822

2003

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Design and Synthesis of Potent Sensitizers of Gram-Negative Bacteria Based on a Cholic Acid Scaffolding

Journal of the American Chemical Society, 1998-04, Vol.120 (12), p.2961-2962

1998

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Anti-Selective Glycolate Aldol Additions with an Oxapyrone Boron Enolate

Organic letters, 2000-09, Vol.2 (19), p.3035-3037

2000

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Synthesis of the Left-Hand Portion of Geldanamycin Using an Anti Glycolate Aldol Reaction

Organic letters, 2001-01, Vol.3 (2), p.259-262

2001

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Paradoxical Increase of Permeability and Lipophilicity with the Increasing Topological Polar Surface Area within a Series of PRMT5 Inhibitors

Journal of medicinal chemistry, 2022-09, Vol.65 (18), p.12386-12402

2022

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Highly selective syn glycolate aldol reactions with boron enolates of Masamune norephedrine esters

Tetrahedron letters, 2001-10, Vol.42 (41), p.7197-7201

2001

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Glycolate aldol reactions with boron enolates of bis-4-methoxyphenyl dioxanone

Tetrahedron letters, 2002-03, Vol.43 (10), p.1789-1792

2002

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A small-molecule inhibitor of C5 complement protein

Nature chemical biology, 2019-07, Vol.15 (7), p.666-668

2019

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Structure based design of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (3), p.365-370

2018

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A Reliable Synthesis of 3-Amino-5-Alkyl and 5-Amino-3-Alkyl Isoxazoles

Synthesis (Stuttgart), 2013-01, Vol.45 (2), p.171-173

2013

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Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells

The Journal of biological chemistry, 2018-12, Vol.293 (52), p.20137-20156

2018

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Full-length myocilin protein is purified from mammalian cells as a dimer

Protein expression and purification, 2018-07, Vol.147, p.38-48

2018

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Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation

The Discovery of N‑(1-Methyl-5-(trifluoromethyl)‑1H‑pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)‑1H‑indole-1-carboxamide (Acrizanib), a VEGFR‑2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

Discovery of Oral VEGFR‑2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

Scaffold Morphing Identifies 3‑Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT)

Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates

The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma

Total Synthesis of (+)-Geldanamycin and (−)-o-Quinogeldanamycin: Asymmetric Glycolate Aldol Reactions and Biological Evaluation

Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D

Lack of involvement of CEP adducts in TLR activation and in angiogenesis

Total Synthesis of (+)-Geldanamycin and (−)-o-Quinogeldanamycin with Use of Asymmetric Anti- and Syn-Glycolate Aldol Reactions

Selective Synthesis of the para-Quinone Region of Geldanamycin

Synthesis of resveratrol using a direct decarbonylative Heck approach from resorcylic acid

Design and Synthesis of Potent Sensitizers of Gram-Negative Bacteria Based on a Cholic Acid Scaffolding

Anti-Selective Glycolate Aldol Additions with an Oxapyrone Boron Enolate

Synthesis of the Left-Hand Portion of Geldanamycin Using an Anti Glycolate Aldol Reaction

Paradoxical Increase of Permeability and Lipophilicity with the Increasing Topological Polar Surface Area within a Series of PRMT5 Inhibitors

Highly selective syn glycolate aldol reactions with boron enolates of Masamune norephedrine esters

Glycolate aldol reactions with boron enolates of bis-4-methoxyphenyl dioxanone

A small-molecule inhibitor of C5 complement protein

Structure based design of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen

A Reliable Synthesis of 3-Amino-5-Alkyl and 5-Amino-3-Alkyl Isoxazoles

Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells

Full-length myocilin protein is purified from mammalian cells as a dimer

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