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Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer’s?

ACS chemical neuroscience, 2012-11, Vol.3 (11), p.857-872

2012

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A facile and rapid route for the synthesis of novel 1,5-substituted tetrazole hydantoins and thiohydantoins via a TMSN3-Ugi/RNCX cyclization

Tetrahedron letters, 2012-10, Vol.53 (42), p.5593-5596

2012

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A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

Molecules (Basel, Switzerland), 2018-10, Vol.23 (10), p.2545

2018

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Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.2673-2682

2009

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Dyrk1A Inhibition as Potential Treatment for Alzheimer’S Disease

Future medicinal chemistry, 2016-04, Vol.8 (6), p.681-696

2016

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Exploiting the divalent nature of isonitriles: a novel Pictet–Spengler amidination process

Tetrahedron letters, 2014-05, Vol.55 (22), p.3328-3331

2014

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DYRK1A inhibition as potential treatment for Alzheimer's disease

Future medicinal chemistry, 2016-04, Vol.8 (6), p.681-696

2016

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A facile and concise route toward the synthesis of novel imidazo-tetrazolodiazepinones via post-condensation modifications of the Ugi-azide adduct

Tetrahedron letters, 2015-09, Vol.56 (38), p.5295-5298

2015

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Synthesis of Diverse Nitrogen-Enriched Heterocyclic Scaffolds Using a Suite of Tunable One-Pot Multicomponent Reactions

Journal of organic chemistry, 2014-06, Vol.79 (11), p.5153-5162

2014

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3-(4-Bromo-phen-yl)-1-butyl-5-[1-(2-chloro-6-methyl-phen-yl)-1H-tetra-zol-5-yl]imidazolidine-2,4-dione

Acta crystallographica. Section E, Structure reports online, 2013-07, Vol.69 (Pt 7), p.o1102-o1103

2013

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From one to two quaternary centers: Ester or nitrile α-alkylation applied to bioactive alkaloids

Tetrahedron, 2018-12, Vol.74 (52), p.7399-7407

2018

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Facile and rapid route for the synthesis of novel norstatine analogs via PADAM-cyclization methodology

Tetrahedron letters, 2012-03, Vol.53 (11), p.1313-1315

2012

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Branching cascades provide access to two amino-oxazoline compound libraries

Bioorganic & medicinal chemistry, 2015-06, Vol.23 (11), p.2656-2665

2015

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Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Journal of controlled release, 2019-02, Vol.296, p.81-92

2019

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Design and Synthesis of Fsp(3)-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

ACS combinatorial science, 2016-06, Vol.18 (6), p.330

2016

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Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.8801-8815

2017

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Abstract 2661: Novel albumin-binding maytansinoids inducing long-term partial and complete tumor regressions in several human cancer xenograft models in nude mice

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2661-2661

2018

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Abstract 1657: Structure-activity relationship studies and biological evaluation of novel maytansinoids, a class of highly selective tubulin inhibitors

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1657-1657

2018

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Abstract 3703: Superior efficacy of novel albumin-binding auristatin E-based prodrugs compared to auristatin E in a panel of human xenograft models in mice

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3703-3703

2018

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Design and Synthesis of Fsp3‑Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

ACS combinatorial science, 2016-06, Vol.18 (6), p.330-336

2016

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Facile and rapid route for the synthesis of novel conformationally constrained norstatine analogs via PADAM-cyclization methodology

Tetrahedron letters, 2012-03, Vol.53 (11), p.1313-1315

2012

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Design and Synthesis of Fsp 3 -Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

ACS combinatorial science, 2016-06, Vol.18 (6), p.330-336

2016

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Total synthesis of dehaloperophoramidine using a highly diastereoselective Hosomi-Sakurai reaction

Chemical communications (Cambridge, England), 2016-01, Vol.52 (71), p.10747-10750

2016

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Gonadotropin-releasing hormone receptor levels and cell context affect tumor cell responses to agonist in vitro and in vivo

Cancer research (Chicago, Ill.), 2008-08, Vol.68 (15), p.6331-6340

2008

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Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (2), p.528-531

2013

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Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer’s?

A facile and rapid route for the synthesis of novel 1,5-substituted tetrazole hydantoins and thiohydantoins via a TMSN3-Ugi/RNCX cyclization

A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity

Dyrk1A Inhibition as Potential Treatment for Alzheimer’S Disease

Exploiting the divalent nature of isonitriles: a novel Pictet–Spengler amidination process

DYRK1A inhibition as potential treatment for Alzheimer's disease

A facile and concise route toward the synthesis of novel imidazo-tetrazolodiazepinones via post-condensation modifications of the Ugi-azide adduct

Synthesis of Diverse Nitrogen-Enriched Heterocyclic Scaffolds Using a Suite of Tunable One-Pot Multicomponent Reactions

3-(4-Bromo-phen-yl)-1-butyl-5-[1-(2-chloro-6-methyl-phen-yl)-1H-tetra-zol-5-yl]imidazolidine-2,4-dione

From one to two quaternary centers: Ester or nitrile α-alkylation applied to bioactive alkaloids

Facile and rapid route for the synthesis of novel norstatine analogs via PADAM-cyclization methodology

Branching cascades provide access to two amino-oxazoline compound libraries

Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Design and Synthesis of Fsp(3)-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT

Abstract 2661: Novel albumin-binding maytansinoids inducing long-term partial and complete tumor regressions in several human cancer xenograft models in nude mice

Abstract 1657: Structure-activity relationship studies and biological evaluation of novel maytansinoids, a class of highly selective tubulin inhibitors

Abstract 3703: Superior efficacy of novel albumin-binding auristatin E-based prodrugs compared to auristatin E in a panel of human xenograft models in mice

Design and Synthesis of Fsp3‑Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

Facile and rapid route for the synthesis of novel conformationally constrained norstatine analogs via PADAM-cyclization methodology

Design and Synthesis of Fsp 3 -Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

Total synthesis of dehaloperophoramidine using a highly diastereoselective Hosomi-Sakurai reaction

Gonadotropin-releasing hormone receptor levels and cell context affect tumor cell responses to agonist in vitro and in vivo

Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells

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