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Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

Cell, 2011-07, Vol.146 (1), p.37-52

2011

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Exosomal cell-to-cell transmission of alpha synuclein oligomers

Molecular neurodegeneration, 2012-08, Vol.7 (1), p.42-42, Article 42

2012

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α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

Current biology, 2014-10, Vol.24 (19), p.2319-2326

2014

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Protein degradation pathways in Parkinson’s disease: curse or blessing

Acta neuropathologica, 2012-08, Vol.124 (2), p.153-172

2012

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Increased Immune Activation by Pathologic α‐Synuclein in Parkinson's Disease

Annals of neurology, 2019-10, Vol.86 (4), p.593-606

2019

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Cellular models of alpha‐synuclein toxicity and aggregation

Journal of neurochemistry, 2019-09, Vol.150 (5), p.566-576

2019

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Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Molecular neurodegeneration, 2020-01, Vol.15 (1), p.5-5, Article 5

2020

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Formation of toxic oligomeric alpha-synuclein species in living cells

PloS one, 2008-04, Vol.3 (4), p.e1867

2008

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SIRT1 protects against α-synuclein aggregation by activating molecular chaperones

The Journal of neuroscience, 2012-01, Vol.32 (1), p.124-132

2012

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Biomarkers in Parkinson's disease: Advances and strategies

Parkinsonism & related disorders, 2016-01, Vol.22 (Suppl 1), p.S106-S110

2016

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Chaperones in Neurodegeneration

The Journal of neuroscience, 2015-10, Vol.35 (41), p.13853-13859

2015

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Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

Scientific reports, 2017-08, Vol.7 (1), p.7690-13, Article 7690

2017

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Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5)

PloS one, 2011-02, Vol.6 (2), p.e14695

2011

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α-Synuclein oligomers and clinical implications for Parkinson disease

Annals of neurology, 2013-02, Vol.73 (2), p.155-169

2013

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Optimizing SH-SY5Y cell culture: exploring the beneficial effects of an alternative media supplement on cell proliferation and viability

Scientific reports, 2024-02, Vol.14 (1), p.4775-4775, Article 4775

2024

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CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

Nature communications, 2019-01, Vol.10 (1), p.53-11, Article 53

2019

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Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein

The Journal of neuroscience, 2011-10, Vol.31 (41), p.14508-14520

2011

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Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

Journal of neuropathology and experimental neurology, 2008-12, Vol.67 (12), p.1149-1158

2008

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Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson's disease

Gut microbes, 2021-01, Vol.13 (1), p.1866974-1866974

2021

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Alpha-synuclein and tau: teammates in neurodegeneration?

Molecular neurodegeneration, 2014-10, Vol.9 (1), p.43-43, Article 43

2014

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Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

The FASEB journal, 2011, Vol.25 (1), p.326-336

2011

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Investigation of Endocytic Pathways for the Internalization of Exosome-Associated Oligomeric Alpha-Synuclein

Frontiers in neuroscience, 2017-03, Vol.11, p.172-172

2017

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APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

Science translational medicine, 2020-02, Vol.12 (529)

2020

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Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation

The Journal of clinical investigation, 2009-11, Vol.119 (11), p.3257-3265

2009

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Molecular Chaperones and Co-Chaperones in Parkinson Disease

The Neuroscientist (Baltimore, Md.), 2012-12, Vol.18 (6), p.589-601

2012

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Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

Exosomal cell-to-cell transmission of alpha synuclein oligomers

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

Protein degradation pathways in Parkinson’s disease: curse or blessing

Increased Immune Activation by Pathologic α‐Synuclein in Parkinson's Disease

Cellular models of alpha‐synuclein toxicity and aggregation

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Formation of toxic oligomeric alpha-synuclein species in living cells

SIRT1 protects against α-synuclein aggregation by activating molecular chaperones

Biomarkers in Parkinson's disease: Advances and strategies

Chaperones in Neurodegeneration

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5)

α-Synuclein oligomers and clinical implications for Parkinson disease

Optimizing SH-SY5Y cell culture: exploring the beneficial effects of an alternative media supplement on cell proliferation and viability

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson's disease

Alpha-synuclein and tau: teammates in neurodegeneration?

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

Investigation of Endocytic Pathways for the Internalization of Exosome-Associated Oligomeric Alpha-Synuclein

APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation

Molecular Chaperones and Co-Chaperones in Parkinson Disease

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