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Microbicide vaginal rings: Technological challenges and clinical development

Advanced drug delivery reviews, 2016-08, Vol.103, p.33-56

2016

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Two into one does go: Formulation development of a multipurpose combination vaginal ring releasing dapivirine and metronidazole for prevention of HIV infection and treatment of bacterial vaginosis

International journal of pharmaceutics, 2023-12, Vol.648, p.123572-123572, Article 123572

2023

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Physicochemical considerations in the formulation development of silicone elastomer vaginal rings releasing 5-nitroimidazole drugs for the treatment of bacterial vaginosis

International journal of pharmaceutics, 2023-09, Vol.644, p.123296-123296, Article 123296

2023

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In vitro release testing methods for drug-releasing vaginal rings

Journal of controlled release, 2019-11, Vol.313, p.54-69

2019

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Mechanical testing methods for drug-releasing vaginal rings

International journal of pharmaceutics, 2019-03, Vol.559, p.182-191

2019

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Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel

International journal of pharmaceutics, 2016-09, Vol.511 (1), p.619-629

2016

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Drug stability and product performance characteristics of a dapivirine-releasing vaginal ring under simulated real-world conditions

International journal of pharmaceutics, 2019-06, Vol.565, p.351-357

2019

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Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers

International journal of pharmaceutics, 2019-10, Vol.569, p.118574-118574, Article 118574

2019

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Packing Polymorphism of Dapivirine and Its Impact on the Performance of a Dapivirine-Releasing Silicone Elastomer Vaginal Ring

Journal of pharmaceutical sciences, 2017-08, Vol.106 (8), p.2015-2025

2017

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A silicone elastomer vaginal ring for HIV prevention containing two microbicides with different mechanisms of action

European journal of pharmaceutical sciences, 2013-02, Vol.48 (3), p.406-415

2013

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Controlling levonorgestrel binding and release in a multi-purpose prevention technology vaginal ring device

Journal of controlled release, 2016-03, Vol.226, p.138-147

2016

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Solid state 13C NMR spectroscopy provides direct evidence for reaction between ethinyl estradiol and a silicone elastomer vaginal ring drug delivery system

International journal of pharmaceutics, 2018-09, Vol.548 (1), p.689-697

2018

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Post-use ring weight and residual drug content as potential objective measures of user adherence to a contraceptive progesterone vaginal ring

Contraception (Stoneham), 2019-09, Vol.100 (3), p.241-246

2019

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Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel

International journal of pharmaceutics: X, 2021-12, Vol.3, p.100091-100091, Article 100091

2021

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In vitro drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel

International journal of pharmaceutics: X, 2022-12, Vol.4, p.100112-100112, Article 100112

2022

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Refining the in vitro release test method for a dapivirine-releasing vaginal ring to match in vivo performance

Drug delivery and translational research, 2023-08, Vol.13 (8), p.2072-2082

2023

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Multipurpose vaginal rings for HIV prevention and non-hormonal contraception

British Journal of Pharmacy, 2022-11, Vol.7 (2), p.S1-S2

2022

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Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings

International journal of pharmaceutics: X, 2021-12, Vol.3, p.100081-100081, Article 100081

2021

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The ex vivo pharmacology of HIV-1 antiretrovirals differs between macaques and humans

iScience, 2022-06, Vol.25 (6), p.104409-104409, Article 104409

2022

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Vaginal rings for delivery of HIV microbicides

International journal of women's health, 2012-01, Vol.4 (default), p.595-605

2012

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Modified Silicone Elastomer Vaginal Gels for Sustained Release of Antiretroviral HIV Microbicides

Journal of pharmaceutical sciences, 2014-05, Vol.103 (5), p.1422-1432

2014

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Lack of in vitro–in vivo correlation for a UC781-releasing vaginal ring in macaques

Drug delivery and translational research, 2015-02, Vol.5 (1), p.27-37

2015

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Development and evaluation of a vaginal ring device for sustained delivery of HIV microbicides to non-human primates

Journal of medical primatology, 2009-08, Vol.38 (4), p.263-271

2009

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Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV-negative women

Journal of acquired immune deficiency syndromes (1999), 2009-08, Vol.51 (4), p.416-423

2009

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Development of a Temperature-recording Vaginal Ring for Monitoring User Adherence

AIDS research and human retroviruses, 2014-10, Vol.30 (S1), p.A146-A146

2014

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Multipurpose Prevention Technology
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Microbicide vaginal rings: Technological challenges and clinical development

Two into one does go: Formulation development of a multipurpose combination vaginal ring releasing dapivirine and metronidazole for prevention of HIV infection and treatment of bacterial vaginosis

Physicochemical considerations in the formulation development of silicone elastomer vaginal rings releasing 5-nitroimidazole drugs for the treatment of bacterial vaginosis

In vitro release testing methods for drug-releasing vaginal rings

Mechanical testing methods for drug-releasing vaginal rings

Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel

Drug stability and product performance characteristics of a dapivirine-releasing vaginal ring under simulated real-world conditions

Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers

Packing Polymorphism of Dapivirine and Its Impact on the Performance of a Dapivirine-Releasing Silicone Elastomer Vaginal Ring

A silicone elastomer vaginal ring for HIV prevention containing two microbicides with different mechanisms of action

Controlling levonorgestrel binding and release in a multi-purpose prevention technology vaginal ring device

Solid state 13C NMR spectroscopy provides direct evidence for reaction between ethinyl estradiol and a silicone elastomer vaginal ring drug delivery system

Post-use ring weight and residual drug content as potential objective measures of user adherence to a contraceptive progesterone vaginal ring

Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel

In vitro drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel

Refining the in vitro release test method for a dapivirine-releasing vaginal ring to match in vivo performance

Multipurpose vaginal rings for HIV prevention and non-hormonal contraception

Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings

The ex vivo pharmacology of HIV-1 antiretrovirals differs between macaques and humans

Vaginal rings for delivery of HIV microbicides

Modified Silicone Elastomer Vaginal Gels for Sustained Release of Antiretroviral HIV Microbicides

Lack of in vitro–in vivo correlation for a UC781-releasing vaginal ring in macaques

Development and evaluation of a vaginal ring device for sustained delivery of HIV microbicides to non-human primates

Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV-negative women

Development of a Temperature-recording Vaginal Ring for Monitoring User Adherence

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